A5022116286- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
- Phytochemistry and Biological Activities
- Chemical synthesis and alkaloids
- Cannabis and Cannabinoid Research
- Natural product bioactivities and synthesis
- Forensic Toxicology and Drug Analysis
- Essential Oils and Antimicrobial Activity
- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Antibiotics Pharmacokinetics and Efficacy
- Natural Compound Pharmacology Studies
- Dye analysis and toxicity
- Medicinal Plants and Neuroprotection
- Olfactory and Sensory Function Studies
- Sesquiterpenes and Asteraceae Studies
- Antioxidant Activity and Oxidative Stress
- Pharmacological Effects and Toxicity Studies
- Chemical Thermodynamics and Molecular Structure
- Drug-Induced Hepatotoxicity and Protection
- Pneumonia and Respiratory Infections
- Nigella sativa pharmacological applications
- Alcoholism and Thiamine Deficiency
- Free Radicals and Antioxidants
- Neuroscience and Neuropharmacology Research
Bezmiâlem Vakıf Üniversitesi
2009-2025
University of Waterloo
2022-2023
Istanbul University
2019
Istanbul Technical University
2011
Hypericum perforatum L. is widely known for its therapeutic properties, including wound healing, antispasmodic effects, and anxiety treatment. This study was examined the total phenolic flavonoid content, antioxidant capacity, anticholinesterase activity of aqueous, ethanolic, water-ethanol extracts from plant's aerial parts also green chemistry sustainability were investigated. Extraction performed under reflux at 60°C. The effect Hyperium L., which to be used in treatment neurological...
In this study, it is aimed to determine some biological activities of the plant Passiflora incarnata L., which primarily utilized for its sedative effects. order to, dry material obtained from herba into a powder using grinder, and extracts were prepared ethanol, water, ethanol-water (50:50; v/v). The total phenolic flavonoid contents these determined pyrocatechol quercetin as standards, respectively. enzyme inhibitions acetylcholinesterase butyrylcholinesterase three different investigated...
The petroleum ether extract of Heracleum platytaenium afforded 8 furocoumarins (psoralen, bergapten, xanthotoxin, pimpinellin, isopimpinellin, sphondin, byakangelicin, and heraclenol) the methanol H. gave only 1 glycosylated dihydrofurocoumarin, apterin. In addition, stigmasterol was also obtained from extract. Structure identification isolated compounds has been achieved by using spectroscopic methods, namely 1D 2D NMR experiments mass spectral analyses. antioxidant activity extracts pure...
Adulteration of dietary supplements are serious threats to public health in all around world.Nowadays, order obtain the intended effect from natural remedies, adulteration products via artificial or harmful chemicals increasing.A rapid LC-MS/MS method for determination capsaicin and dihydrocapsaicin Fortis C18 (150 x 3 mm; µm) column at 25 °C was developed validated a mixture mobile phase A (1 % formic acid solution 0.1 ammonium formate water) B methanol) with gradient program flow rate 0.35...
The study of non-polar compounds in aqueous environments has always been challenging due to their poor solubility media. low affinity toward polar solutions facilitates attachment glassware, which results unstable sample concentrations. To address this challenge, and enable the preparation a stable mixture hydrophobic an aquatic environment, we introduce in-vial standard water generating system consisting vial containing appropriate solution polydimethylsiloxane thin film spiked with target...
A sensitive and selective HPLC method with fluorometric detection was developed for the determination of saxagliptin (SGX) in human plasma applied to a pharmacokinetic study. SGX precolumn derivatized fluorescamine, fluorescent derivative separated on an RP C18 column using mobile phase composed acetonitrile-10 mM orthophosphoric acid by isocratic elution flow rate 1.3 ml/min. The based measurement fluorescence at 378 nm, excitation 463 nm. calibration curve linear over range 3.0–100.0...
Abstract In this study, a new, sensitive and selective high-performance liquid chromatographic method was developed for the determination of meropenem (MEM) in human serum. method, C18 column (3.9 × 150 mm, 5 μm) selected as stationary phase at 30°C, methanol: acetic acid solution mixture used mobile with gradient program. Chromatographic separation carried out flow rate 1 mL/min, detection performed 300 nm diode array detector. Doripenem an internal standard, analytes were extracted from...
Public use of Salvia species and their importance in the scientific world is continually increasing. It known that this are mostly due to terpenoid compounds they contain. In context, terpenoid-steroid-flavonoid contents extracts six endemic (S. kurdica, S. pseudeuphratica, rosifolia, siirtica, cerino-pruinosa var. elazigensis) prepared with different solvents were determined by gas chromatography-mass spectrometry. Within framework ingredient analysis, content analysis ethanol root, branch,...
This study presents a simple, rapid, and accurate spectrophotometric method for the determination of Aripiprazole (ARP) in tablets. The procedure is based on reaction ARP with 7,7,8,8-tet racyanoquinodimethane (TCNQ), producing colored product that was quantitated spectrophotometrically at 392 nm. Various variables affecting were optimized. exhibited good linearity range correlation coefficient 0.9994, observed as 0.25–3 μg/mL. developed validated according to International Council...
Introduction : In patients with chronic kidney disease (CKD), uremic toxins accumulate in blood and cannot be excreted urine. Accumulation of these has negative effects on many body functions. Because the importance toxins, we developed validated a simple, sensitive, accurate, precise method for determination two main toxins: phenol p-cresol human Materials methods Separation analytes urine samples was achieved by reverse-phase high-performance liquid chromatography (RP-HPLC) C18 column at...
Objective: Two simple, rapid and sensitive methods were developed for determination of Erdosteine (ERD) in pure form as well their pharmaceutical formulations. Methods:The based on formation colored charge transfer complexes with ERD chloranil (CA) 7,7,8,8-tetracyanoquinodimethane (TCNQ).The obtained charge-transfer measured at 454 843 nm CA TCNQ methods, respectively.Optimization different experimental conditions investigated.Results: Beer's plots obeyed a general concentration range 10-500...
Current scientific studies indicate that carotenoids (CRTDs) are beneficial for maintaining health and lowering the risk of different pathologies. Considering increasing role in healthcare, determination carotenoid content foods become important. Mostly, analytical procedures used this aim, based on extraction techniques followed by procedures, especially high performance liquid chromatography. In publication, a review various developed food commodities starting from 2006 up to now, has been...
Polybrominated diphenyl ethers (PBDEs), which are used as flame retardants, widely additives so many different kind of materials that consumed by public. Current researches reveal a significant increase in the levels PBDEs human biological fluids all around world. According to International Agency for Research on Cancer (IARC), declarated carcinogenic agents and additionally considerable risks have been shown animal studies such liver damage, alteration thyroid hormone levels, neurotoxicity...
The COVID-19 pandemic that broken out in 2020 is becoming more worrying for the world. Although there no 100 % success against COVID-19, certain synthetic drugs are currently used despite various side effects. Therefore, studies on discovery of new treatment alternatives come to fore. Studies so far show natural products still important resources therapeutic agents. Plant-derived essential oils complex volatiles composed phytochemicals, mostly containing compounds such as sesquiterpenes,...