A5073375648- Metabolomics and Mass Spectrometry Studies
- Bone health and treatments
- Diet, Metabolism, and Disease
- Neurological Disorders and Treatments
- Bone Metabolism and Diseases
- Traditional Chinese Medicine Analysis
- Cancer, Hypoxia, and Metabolism
- Neurological Disease Mechanisms and Treatments
- Bone health and osteoporosis research
- Ginseng Biological Effects and Applications
Peking University
2025
Lanzhou University
2022-2024
Clinical trials of receptor-biased interleukin-2 (IL-2) variants in cancer therapy show limited efficacy. To investigate, we re-evaluated divergent IL-2 PEGylates (generated via site-specific PEGylation at residues D20 (not-β) and Y45 (not-α)), alone or combination. Results showed the not-α variant (Y45) activates regulatory T cells (Tregs) βγ chain binding, overriding CD8+ impairing Conversely, not-β (D20) is inert but spatially blocks Y45's engagement, suppressing Treg activation. also...
This study aimed to systematically evaluate the efficacy of
With high morbidity and disability, osteoporosis is a worldwide bone metabolism disease, regulated by complex pathological processes. Insufficient osteogenesis greatly essential to osteoporosis. Traditional Chinese Medicine, natural herbal medicine system, has increasingly attracted attention all over the world. Bugu Shengsui Decoction, compound formula for osteoporosis, significant clinical effects in treatment of Yet detailed mechanisms are unclear. Thus, we investigated mechanism...