A5033078365- Animal Disease Management and Epidemiology
- T-cell and Retrovirus Studies
- Vector-Borne Animal Diseases
- Toxoplasma gondii Research Studies
- CNS Lymphoma Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Retinoids in leukemia and cellular processes
- Herpesvirus Infections and Treatments
- Lymphoma Diagnosis and Treatment
- Rabies epidemiology and control
- Reproductive System and Pregnancy
- Natural Compounds in Disease Treatment
- HIV/AIDS Impact and Responses
- Autophagy in Disease and Therapy
- Nigella sativa pharmacological applications
- Bioactive Natural Diterpenoids Research
- Viral-associated cancers and disorders
American University of Beirut
2018-2021
Adult T cell leukemia (ATL) is an aggressive malignancy secondary to chronic infection by the human T-cell virus type 1 (HTLV-1) infection. Two viral proteins, Tax and HBZ, play central roles in ATL leukemogenesis. expression transforms cells vitro induces ATL-like disease mice. also a rough eye phenotype increases hemocyte count Drosophila melanogaster , indicative of transformation. Among multiple functions, modulates enhancer zeste homolog 2 (EZH2), methyltransferase Polycomb Repressive...
Primary effusion lymphoma (PEL) is a rare aggressive subset of non-Hodgkin B cell lymphoma. PEL secondary to Kaposi sarcoma herpes virus (KSHV) and predominantly develops in serous cavities. Conventional chemotherapy remains the treatment choice for yields high response rates with no significant comorbidities. Yet, often fails achieving or maintaining long-term remission. Lenalidomide (Lena), an immunomodulatory drug, displayed some efficacy PEL. On other hand, arsenic trioxide (ATO)...
Toxoplasmosis is a prevalent parasitic disease caused by Toxoplasma gondii ( T. ). Under the control of host immune system, persists as latent bradyzoite cysts. Immunosuppression leads to their reactivation, potentially life-threatening condition. Interferon-gamma (IFN-γ) controls different stages toxoplasmosis. Here, we addressed role parasite surface antigen P18, belonging Surface-Antigen 1 (SAG-1) Related Sequence (SRS) family, in cyst-forming strain. Deletion P18 gene (KO ) impaired...