A5034328990- Hydrogels: synthesis, properties, applications
- Polymer Surface Interaction Studies
- Marine Biology and Environmental Chemistry
- Advanced biosensing and bioanalysis techniques
- Silk-based biomaterials and applications
- Biosensors and Analytical Detection
- Innovative Microfluidic and Catalytic Techniques Innovation
- Antimicrobial Peptides and Activities
- Nanoparticle-Based Drug Delivery
- Advanced Polymer Synthesis and Characterization
- Electrospun Nanofibers in Biomedical Applications
- Advanced Materials and Mechanics
- Bone Tissue Engineering Materials
- Advanced Biosensing Techniques and Applications
- Semiconductor materials and devices
- Calcium Carbonate Crystallization and Inhibition
- Ocular Surface and Contact Lens
- Glycosylation and Glycoproteins Research
- Diabetic Foot Ulcer Assessment and Management
- Metal-Organic Frameworks: Synthesis and Applications
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Diabetes Management and Research
- Cardiac Health and Mental Health
- Blood Pressure and Hypertension Studies
Institute of Materials Research and Engineering
2017-2025
Agency for Science, Technology and Research
2017-2025
Singapore National Eye Center
2025
National University of Singapore
2019-2024
National University Heart Centre Singapore
2023
University of California, Santa Barbara
2021-2022
Star Technology and Research (United States)
2018
Nanyang Technological University
2014-2017
Despite the advanced detection and sterilization techniques available today, sensitive diagnosis complete elimination of bacterial infections remain a significant challenge. A strategy is reported for efficient capture (ca. 90%) based on synergistic effect nanotopography surface chemistry substrate attachment adhesion. The outstanding bacterial-capture capability functionalized nanostructured enables rapid highly down to trace concentrations pathogenic bacteria (10 colony-forming units...
We report on the marine fouling and release effects caused by variations of surface mechanical properties microtopography engineering polymers. Polymeric materials were covered with hierarchical micromolded topographical patterns inspired shell decapod crab Myomenippe hardwickii. These micropatterned surfaces deployed in field static immersion tests. PDMS, polyurethane, PMMA higher elastic modulus hardness found to accumulate more exhibited poor properties. The results indicate interplay...
In recent years, multidrug therapy has gained increasing popularity due to the possibility of achieving synergistic drug action and sequential delivery different medical payloads for enhanced treatment efficacy. While a number composite material release platforms have been developed, few combine bottom-up design versatility metal-organic frameworks (MOFs) tailor behavior, with convenience temperature-responsive hydrogels (or thermogels) in their unique ease administration formulation. Yet,...
Abstract Objective To identify diabetic maculopathy features from photographic screening that are predictive of treatment on referral to a tertiary care centre. Methods Retrospective review participants who underwent by Singapore Integrated Diabetic Retinopathy Programme 2015 2019. Participants visual acuity (VA) test and non-stereoscopic retinal photographs. Maculopathy include haemorrhages, microaneurysm hard exudates (HE), stratified inner outer zone (1 1-2 disc diameter fovea...
Diabetes when left untreated can lead to various complications in the eye – at its most severe, leading vision loss. Injectable thermogels provide a minimally-invasive platform that facilitates treatment and recovery of these patients.
The solution structure of a suckerin protein obtained by NMR illustrates β-sheet conformation with stabilising aromatic interactions in dynamic domains.
Abstract Despite the advanced detection and sterilization techniques available today, sensitive diagnosis complete elimination of bacterial infections remain a significant challenge. A strategy is reported for efficient capture (ca. 90 %) based on synergistic effect nanotopography surface chemistry substrate attachment adhesion. The outstanding bacterial‐capture capability functionalized nanostructured enables rapid highly down to trace concentrations pathogenic bacteria (10 colony‐forming...
Injectable thermoresponsive hydrogels (thermogels), valued for their conformability and minimal invasiveness, are increasingly used as in situ forming implants drug delivery regenerative scaffolds. These gels exhibit sol-to-gel phase transitions at body temperature. As localized depots scaffolds, these determine the chemical mechanical environments could dramatically influence release kinetics of drugs or fate cells. Current synthetic approaches thermogels, however, often limit ability to...
Area-selective atomic layer deposition (ALD) has the potential to significantly improve current fabrication approaches by introducing a bottom-up process in which robust and conformal thin films are selectively deposited onto patterned substrates. This approach requires selective areas of substrates be masked inhibit deposition. Spontaneous self-assembly organization mask, incorporating adhesion other functions, particularly attractive for this role as they do not require separate patterning...
Thermogels, a class of hydrogels which show spontaneous sol-gel phase transition when warmed, are an important soft biomaterials. To date, however, most amphiphilic polymers that able to form thermogels in aqueous solution uncharged, and the influence ionisable groups on thermogelation largely unknown. Herein, we report first example polyanionic multi-block copolymer, containing multiple pendant carboxylate groups, can transparent spontaneously warmed up physiological temperature. We...
Abstract Funding Acknowledgements Type of funding sources: None. Background A large proportion premature deaths are related to metabolic diseases in the young adult population. We examined global trends and mortality using estimates from Global Burden Diseases, Injuries Risk Factors Study (GBD) 2019 individuals aged below 40 years. Methods From 2000-2019, prevalence, deaths, disability-adjusted life years (DALYs) were described for (type 2 diabetes mellitus [T2DM], hypertension,...
Abstract Funding Acknowledgements Type of funding sources: None. Background Previous studies have shown that females with type 2 diabetes mellitus (T2DM) may an excess mortality risk compared to males. Furthermore, other reported sex differences in managing cardiovascular factors, such as controlling hypertension and hypercholesterolemia. Purpose With the growing evidence from systematic reviews examining outcomes for patients T2DM, umbrella review is essential next step synthesising...
Structural versatility and multifunctionality of biological materials have resulted in countless bioinspired strategies seeking to emulate the properties nature. The nanostructured egg case swell sharks is one toughest permeable membranes known and, thus, presents itself as a model system for where conflicting properties, strength porosity, are desirable. possesses an intricately ordered structure that designed protect delicate embryos from external environment while enabling respiratory...
Glycated hemoglobin (HbA1c) is recommended by the American Diabetes Association (ADA) for diagnosis, monitoring, and screening of diabetes/prediabetes [1].HbA1c correlates with microvascular macrovascular complications diabetes [2][3][4][5][6].The within-subject biological variation HbA1c smaller (3.6%) when compared to fasting plasma glucose (FPG -5.7%) oral tolerance test (oGTT -16.7%) [7].HbA1c assays are internationally harmonized due National Glycohemoglobin Standardization Program...