A5100674666- Biological and pharmacological studies of plants
- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- Plant biochemistry and biosynthesis
- Polysaccharides and Plant Cell Walls
- Ginger and Zingiberaceae research
- Dermatology and Skin Diseases
- Pharmacological Effects of Natural Compounds
- Advanced Manufacturing and Logistics Optimization
- Drug-Induced Hepatotoxicity and Protection
- Plant-based Medicinal Research
- Reproductive Biology and Fertility
- Connective tissue disorders research
- Eicosanoids and Hypertension Pharmacology
- Toxin Mechanisms and Immunotoxins
- Vascular anomalies and interventions
- Breast Lesions and Carcinomas
- Advanced Proteomics Techniques and Applications
- Prenatal Screening and Diagnostics
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Neurological disorders and treatments
- Cardiovascular Issues in Pregnancy
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Valve Diseases and Treatments
Zhoukou Normal University
2022-2025
Jinshan Hospital of Fudan University
2016-2024
Marquette University
2022
Medical College of Wisconsin
2022
Guangdong Academy of Forestry
2007-2021
University of Miami
2021
Athinoula A. Martinos Center for Biomedical Imaging
2020
Massachusetts General Hospital
2020
Anyang Hospital of Traditional Chinese Medicine
2020
First Affiliated Hospital of Fujian Medical University
2020
Psoriasis is a chronic inflammatory immune disease with undefined pathogenesis. It associated T cells, and the IL-23/IL17 axis believed to be crucial in The present treatments have side effects that influence compliance of patients. Tea polyphenol extracted from tea polyphenols, its main active ingredient Epigallocatechin-3-gallate (EGCG), which has been shown antioxidant, anti-tumor, anti-ultraviolet radiation effects. Here, we aim report EGCG can inhibit imiquimod (IMQ)-induced...
Essential oil of Pogostemon cablin (Blanco) Benth. has been reported to exhibit strong insecticidal activities, but few studies have focused on the activity its main individual constituent, pogostone (PO). The goal this research was investigate PO against two harmful noctuid insects, Spodoptera litura (Fabricius) and exigua (Hübner).In a no-choice assay, exhibited antifeedant S. exigua. showed pronounced larvicidal including oral toxicity (LC50 986.88 mg L(-1) 545.61 respectively) contact...
The effect of polysaccharides isolated from Dendrobium officinale (DOP) on acetaminophen‐ (APAP‐) induced hepatotoxicity and the underlying mechanisms involved are investigated. Male Institute Cancer Research (ICR) mice were randomly assigned to six groups: (1) control, (2) vehicle (APAP, 230 mg/kg), (3) N ‐acetylcysteine (100 (4) 50 mg/kg DOP, (5) 100 (6) 200 DOP. Alanine aminotransferase (ALT) aspartate (AST) levels in serum glutathione (GSH), malondialdehyde (MDA), catalase (CAT), total...
Two novel polysaccharides DOP1-DES and DOP2-DES with molecular weight of 297,911 Da 30,400 were extracted by using DESs from Dendrobium officinale for the first time, purified macroporous resin AB-8, Sephadex G75 G200 chromatography. Besides, effect extraction temperature, molar ratio DES, reaction time compound enzymes concentration on yield investigated. Monosaccharide composition analysis showed composed D-glucose D-mannose 2.2:1 3.7:1, respectively. Structural features investigated a...
With the rapid growth of e-commerce and ongoing innovations in logistics industry, intelligent unmanned warehousing systems have emerged to significantly enhance operational efficiency reduce costs. In these systems, two critical stages order assignment path planning are interconnected through racks picking process. However, prior research has largely overlooked their joint optimization. this paper, we investigate real time task problem (RTTP) warehousing, where dynamically assigned orders...
To elucidate the timeframe and spatial patterns of cortical reorganization after different stroke-induced basal ganglia lesions, we measured thickness at 5 time points over a 6-month period. We hypothesized that would occur very early that, along with motor recovery, it vary based on stroke lesion site.Thirty-three patients unilateral 23 healthy control participants underwent MRI scanning behavioral testing. further decrease heterogeneity, split into 2 groups according to whether or not...
Triterpenoid saponins constitute a diverse class of bioactive compounds in medicinal plants. Salicylic acid (SA) is an efficient elicitor for secondary metabolite production, but transcriptome-wide regulatory network SA-promoted triterpenoid saponin biosynthesis remains little understood. In the current study, we described establishment hairy root culture system Psammosilene tunicoides , saponin-producing herb China, using genetic transformation by Agrobacterium rhizogenes . Compared to...
Constipation is a common disorder that significant source of morbidity among people around the world ranging from 2% to 28%. Dendrobium officinale Kimura et Migo traditional herbal medicine and health food used for tonicity stomach promotion body fluid production in China. This study aimed prepare ultrafine powder (UDO) investigate its laxative effect potential mechanism mice with diphenoxylate-induced constipation. Results indicated mean diameter (d50) UDO obtained by ball milling was 6.56...
Background Computed tomography (CT) is an effective way to scan for lung cancer. The classification of nodules in CT screening completely doctor dependent, which has drawbacks, including difficulty classifying tiny nodules, subjectivity, and high false-positive rates. In recent years, deep convolutional neural networks, a learning technology, have been shown be medical imaging diagnosis. Herein, we propose network technique (TransUnet) automatically classify accurately. Methods TransUnet...
Two new pentacyclic triterpene saponins, named akebiaoside K (1) and N (2), were isolated from the leaves of Akebia trifoliata, together with five known triterpenoids 3-7. They all A. trifoliata for first time. Their structures established by spectral chemical means. Triterpenes 5 7 found to show moderate in vitro cytotoxicity against human tumor A549, HeLa HepG2 cell lines, IC50 values ranging 0.023 0.038 mM. 5-7 further revealed significant α-glucosidase inhibitory activity 0.040 0.220 mM,...
The study aimed to evaluate the protective effect of Dendrobium officinale flower extraction (DOFE) on alcohol‐induced liver injury and its probable mechanisms in mice. chemical composition DOFE was performed via UPLC/MS. Male Kunming mice were used establish models by oral gavage 56% alcohol. Results showed that dramatically attenuated increased serum levels alanine aminotransferase (ALT), aspartate (AST), total cholesterol (TC), triacylglycerol (TG). Meanwhile, hematoxylin eosin Oil Red O...
To explore potential metabolomics biomarkers in predicting post-herpetic neuralgia (PHN) induced by herpes zoster (HZ). A total of 90 eligible patients were prospectively enrolled and assigned into an acute pain (ACP) group a PHN group. Serum samples collected before clinical intervention to perform profiling analyses using gas chromatography mass spectrometry (GC-MS). Key metabolites identified partial least squares discriminant analysis (PLS-DA). binary logistic regression was used build...
Background Skin squamous cell carcinoma (SCC) is a prevalent malignancy, and dysregulated lipid metabolism has been implicated in its pathogenesis. However, detailed characterization of alterations SCC remains limited. Methods We analyzed metabolic variations tissue samples from 34 patients adjacent healthy tissues (located more than 1 cm the tumor margin) using liquid chromatography-mass spectrometry (LC-MS). Data visualization discriminatory profiles were identified principal component...
Prior computational and imaging studies described changes in flow patterns for patients with Marfan syndrome, but are lacking related populations. This pilot study addresses this void by characterizing wall shear stress (WSS) indices Loeys-Dietz undifferentiated connective tissue diseases. Using aortic valve-based velocity profiles from magnetic resonance as input to patient-specific fluid structure interaction (FSI) models, we determined local throughout the aorta four various diseases...
The aim of this study was to investigate the hepatoprotective effect ultrafine powder Dendrobium officinale (UDO) against acetaminophen (APAP)-induced liver injury in mice. ICR mice were orally administered with UDO (100, 200, 400 mg/kg/day) for 14 days before intraperitoneal injection APAP. results showed that exhibited a significant dose-dependently preventive on APAP-induced hepatotoxicity. Pretreatment significantly reduced serum levels alanine transaminase and aspartate...
Tropical secondary forests own enormous potential and ecological function due to their vast area, are an increasingly important component of the forest resources in tropics. This paper reviews main research outcomes during succession process. Soil-stored seeds significantly contribute development forests, increased levels incident light temperature stimulate seed germination, whereas remnant vegetation predator have strongly negative influence on rate initial colonization. Species number...
Summary The finding of conjoined oocytes is a rare occurrence that accounts for only 0.3% all human retrieved oocytes. This phenomenon quite different from traditional single oocyte emanating one follicle, and may result in dizygotic twins mosaicism. Given the insufficient evidence on how to approach oocytes, their fate variable among vitro fertilization (IVF) centres. In this observational report, we propose new protocol use these using intracytoplasmic sperm injection (ICSI), laser-cutting...
this paper studied urban road waterlog risk problem of Handan based on the two-dimensional information diffusion model, fist to collected original data including distribution spots, raining strength, history, danger sources and bearing objects with joint meteorology department, municipal drainage department social communities, then construct relationship model between indexes strength depth for each spots.With a certain can give prediction spot, it estimate scenarios spot.Studies show that,...
Objective To analysis the occurrence status of breast disease in married women Tangshan area, and to provide basis for early prevention cancer this region. Methods 773 area were given mammography examination. The tissue biopsy or surgical treatment was recommended patients with above grade 3 imaging reporting data system (BI -RADS) classification obtain pathological diagnosis. Results In 773 women, 482 cases (62.35 %) diagnosed as BI-RADS 2 below, 256 (33.12 3, 33 (4.27 4, (0.26...