A5101436582- Eicosanoids and Hypertension Pharmacology
- Pharmacogenetics and Drug Metabolism
- Hormonal Regulation and Hypertension
- Phytochemicals and Medicinal Plants
- Traditional Chinese Medicine Analysis
- Plant-based Medicinal Research
- Inflammatory mediators and NSAID effects
- Tryptophan and brain disorders
- Nuclear Receptors and Signaling
- Antioxidant Activity and Oxidative Stress
- Monoclonal and Polyclonal Antibodies Research
- Neurological Disease Mechanisms and Treatments
- Phytochemistry and biological activity of medicinal plants
- Fatty Acid Research and Health
- Genetic Syndromes and Imprinting
- Science, Research, and Medicine
- Traditional Chinese Medicine Studies
- Antibiotics Pharmacokinetics and Efficacy
- Biological and pharmacological studies of plants
- Metabolomics and Mass Spectrometry Studies
- Axon Guidance and Neuronal Signaling
- Apelin-related biomedical research
- Lipid metabolism and disorders
- Schizophrenia research and treatment
- Pregnancy and Medication Impact
Air Force Medical University
2025
General Hospital of Guangzhou Military Command
2009-2019
Numerous references made clear that Triphala is revered as a multiuse therapeutic and perhaps even panacea historically. Nevertheless, the protective mechanism of on cardio-cerebral vascular diseases (CCVDs) remains not comprehensive understanding. Hence, network pharmacology-based method was suggested in this study to address problem. This based pharmacology bioinformatics analysis. Information compounds herbal medicines formula acquired from public databases. Oral bioavailability well...
Bone fracture is increasing in patients with type 2 diabetes mellitus (T2DM) due to skeletal fragility. Most antidiabetics are expected reduce the incidence of T2DM, however results disappointing. Metformin and GLP-1 receptor agonists have a neutral or minor positive effect reducing fractures. We aim reveal mechanism T2DM treated metformin exendin-4, explore key regulators responsible for bone fragility T2DM. Trabecular cortical masses mice were analyzed using micro-computed tomography....
CYP3A4 is a major member of the cytochrome P450 (CYP) enzymes which play crucial roles in cardiovascular diseases. Recently, novel polymorphism gene, IVS10+12G>A, named CYP3A4*1G (rs2242480), has been identified. The aim this study was to evaluate potential relationship between allele and susceptibility coronary heart disease (CHD). A total 628 individuals (322 unrelated patients with CHD 306 age- sex-matched healthy controls) were investigated study. Polymerase chain reaction-restriction...
Ischemic stroke is a common cerebrovascular disease with substantial morbidity and mortality worldwide. However, therapeutic options to minimize the cerebral ischemia-reperfusion (I/R) injury are limited. In China, combination of herb Danshen (Salvia miltiorrhiza Bge) Honghua (Carthamus tinctorius L.) effective for treatment in patients but its underlying mechanism requires further investigation. Our study was conducted evaluate explore synergistic effects two ingredients Danshensu...
Renal ischemia-reperfusion (I/R) injury is associated with high morbidity and mortality as there currently no available effective therapeutic strategy which to treat this injury. Thus, the aim of study was investigate potential protective effects brazilin, a major active component Chinese medicine Caesalpinia sappan L., against renal I/R in vitro vivo. Rats were subjected removal right kidney left (ischemia for 45 min followed by reperfusion 24 h). Treatment brazilin (30 mg/kg, administered...
The present study aimed to evaluate the impact of CYP3A4*1G allele on pharmacokinetics atorvastatin in Chinese Han patients with coronary heart disease (CHD). Twenty male CHD different genotypes were orally administered a single 20 mg dose atorvastatin. Plasma concentrations and 2-hydroxyatorvastatin measured by high-performance liquid chromatography tandem mass spectrometry. mean area under plasma concentration-time curve from 0 infinity (AUC0-∞ ) subjects CYP3A4*1G/*1G genotype 36% or 25%...
Terminalia chebula (TC), a kind of Combretaceae, is widely used herb in India and East Asia to treat cerebrovascular diseases. However, the potential mechanism neuroprotective effects TC at metabonomics level still not clear. The present study focused on stroke model. Rats were divided randomly into sham, model, groups. group intragastrically administered with for 7 days after middle cerebral artery occlusion (MCAO) operation. sham model groups received vehicle same length time....
Abstract Objective To evaluate the effects of treatment with risperidone and aripiprazole on serum prolactin, testosterone estradiol levels in female patients schizophrenia China. Methods In retrospective study, Data were collected included 30 monotherapy. prospective Another schizophrenic randomized to receive or adjunctive for six weeks. Serum measured. Results both studies significantly decreased after compared baseline (P<0.05), prolactin remained at a high level. group study...
Background . Hypertension, including essential and secondary hypertension, is a multifactorial disease, affecting more than one billion people worldwide. Secondary hypertension can result from mutations of cullin-3 ( CUL3 ); however, whether polymorphisms are associated with (EH) has not been reported. Here, we investigated the association between SNPs rs17479770 rs3738952 EH in Chinese Han population. Methods This case-control study 520 representatives, 259 patients 261 normotensive...
Atherosclerosis (AS) is a common pathological basis for the development of various cardiovascular and cerebrovascular diseases, however, currently, no effective treatment against AS has been established. It previously suggested that intravascular cytochrome P450 (CYP) oxidase involved in pathogenesis AS. The present study investigated role P450, family 2, subfamily J, polypeptide 2 (CYP2J2), most subtype CYP human body, occurrence CYP2J2 was overexpressed umbilical vein endothelial cells...
Hypertension, including secondary and essential hypertension (EH) variants, is a multifactorial disease, affecting more than one billion people worldwide. Secondary results from mutations in the putative gene KLHL3 (Kelch-like protein 3); however, it has not been reported whether polymorphisms are associated with EH. Here, we investigated association between (rs2301708 rs7444370) EH Chinese Han population.This case-control study included 522 subjects-260 patients 262 normotensive controls...
By means of literature review existing laws and regulations,an analysis was made on main setbacks found in the clinical trials regulation medical devices China.The authors proposed to enact improve such regulations as soon possible. Key words: Medical devices; Clinical trials; Operation; Laws; Regulations