A5100329354- Phytochemistry and biological activity of medicinal plants
- Plant Gene Expression Analysis
- Pharmacogenetics and Drug Metabolism
- Microbial Metabolism and Applications
- Plant tissue culture and regeneration
- Eicosanoids and Hypertension Pharmacology
- Plant biochemistry and biosynthesis
- Venomous Animal Envenomation and Studies
- Bacteriophages and microbial interactions
- Monoclonal and Polyclonal Antibodies Research
- Healthcare and Venom Research
- Biological Stains and Phytochemicals
- Pharmacological Effects of Natural Compounds
- Microfluidic and Capillary Electrophoresis Applications
- Phytochemistry and Biological Activities
- Hormonal Regulation and Hypertension
- Microbial Metabolic Engineering and Bioproduction
- Biological and pharmacological studies of plants
- Analytical Chemistry and Chromatography
- Toxin Mechanisms and Immunotoxins
- Enzyme Production and Characterization
- Gene expression and cancer classification
- Pain Mechanisms and Treatments
- Food Quality and Safety Studies
- Ginger and Zingiberaceae research
General Hospital of Guangzhou Military Command
2010-2019
South China University of Technology
2005-2019
Southern Medical University
2016-2019
Bioscience (China)
2014-2016
Guangzhou Experimental Station
2014
Northeast Agricultural University
2014
Shanghai Innovative Research Center of Traditional Chinese Medicine
2012
Guangzhou University
2009-2010
South China Normal University
2007-2009
Yong In University
2009
CYP3A4 is a major member of the cytochrome P450 (CYP) enzymes which play crucial roles in cardiovascular diseases. Recently, novel polymorphism gene, IVS10+12G>A, named CYP3A4*1G (rs2242480), has been identified. The aim this study was to evaluate potential relationship between allele and susceptibility coronary heart disease (CHD). A total 628 individuals (322 unrelated patients with CHD 306 age- sex-matched healthy controls) were investigated study. Polymerase chain reaction-restriction...
The present study aimed to evaluate the impact of CYP3A4*1G allele on pharmacokinetics atorvastatin in Chinese Han patients with coronary heart disease (CHD). Twenty male CHD different genotypes were orally administered a single 20 mg dose atorvastatin. Plasma concentrations and 2-hydroxyatorvastatin measured by high-performance liquid chromatography tandem mass spectrometry. mean area under plasma concentration-time curve from 0 infinity (AUC0-∞ ) subjects CYP3A4*1G/*1G genotype 36% or 25%...
Background: The CYP19A1 enzyme (aromatase) encoded by the cytochrome P450 (CYP) 19A1 gene influences final step in biosynthesis of estrogen, which has been associated with Alzheimer disease (AD). It is possible that genetic polymorphisms could influence risk AD altering expression CYP19A1. ε4 allele apolipoprotein E (APOE) gene, most significant known factor for AD, may mask effects other loci. Methods: To assess potential association we conducted a case–control study Chinese Han population...
Friable calli of Polygonum multiflorum Thunb have been induced in MS medium supplemented with 6-benzylaminopurine (6-BA) and kinetin (KT). Suspension cultures were initiated from friable by inoculating liquid shake flasks the dark 25 °C on an orbital shaker at 100 rpm. The maximum dry weight (DW, 7.85 g/L) 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glycoside (THSG, 56.39 mg/L) suspension cells was obtained after 16 days culture. Both methyl jasmonate (MeJA) salicylic acid (SA) could increase THSG...
The differential constituents in leaves, stems and roots of Polygonum multiflorum Thunb. were analyzed by ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC/ESI-Q-TOF-MS) multivariate statistical analysis. established extraction analysis method showed relative standard deviations (RSDs) for intra-day precision less than 3.40%, repeatability 4.06% stability 5.10%. Principal component orthogonal projections to latent...
Neuropathic pain is a devastating neurological disease that seriously affects patients’ quality of life. Despite high level incidence, the underlying mechanisms neuropathic are still poorly understood. However, recent evidence supports prominent role spinal glial cells in states. In our laboratory, we observed najanalgesin, novel peptide isolated from venom Naja naja atra, exerts significant analgesic effects on acute mice and rats. The objective present study was to determine whether glia...
Stilbenes are natural phenolic compounds which function as antimicrobial phytoalexins in plants and affect human health cardioprotective, antibaceteria, antioxidative antineoplastic agents. In this review, the progresses of study on relevant enzymes, genes, regulation mechanism biosynthesis pathway stilbenes described. Here we introduce a holistic systematic method researching genes other regulatory factors stilbenes—Systems biology. The application knowledge relative mechanisms metabolic...
To isolate high-quality total RNA from Fallopia multiflora tuberous roots is difficult because of the presence high levels carbohydrates, phenolics, and other secondary metabolites. Since several procedures specialized for isolation polysaccharides phenols rich tissues have resulted in poor yields, this study, we developed a modified protocol that was derived traditional CTAB method. The able to produce intact F. multiflora. yield more than 0.15 mg/g fresh weight, with an A260/A280 ratio...
Background . Hypertension, including essential and secondary hypertension, is a multifactorial disease, affecting more than one billion people worldwide. Secondary hypertension can result from mutations of cullin-3 ( CUL3 ); however, whether polymorphisms are associated with (EH) has not been reported. Here, we investigated the association between SNPs rs17479770 rs3738952 EH in Chinese Han population. Methods This case-control study 520 representatives, 259 patients 261 normotensive...
To further understand the evolution of snake mitochondrial genomes, complete DNA (mtDNA) sequences were determined for representative species from two families: Many-banded krait, Banded Chinese cobra, King Hundred-pace viper, Short-tailed mamushi, and Chain viper. Thirteen protein-coding genes, 22-23 tRNA 2 rRNA control regions identified in these mtDNAs. Duplication region translocation tRNAPro gene notable features These results rearrangement comparisons confirm correctness traditional...