A5101772108- Planetary Science and Exploration
- Astro and Planetary Science
- Photonic and Optical Devices
- Advanced Glycation End Products research
- Phagocytosis and Immune Regulation
- Endoplasmic Reticulum Stress and Disease
- Pancreatic function and diabetes
- SARS-CoV-2 and COVID-19 Research
- Fibroblast Growth Factor Research
- Synthesis of Organic Compounds
- Liver physiology and pathology
- Renal and related cancers
- GDF15 and Related Biomarkers
- Growth Hormone and Insulin-like Growth Factors
- Cyclopropane Reaction Mechanisms
- Phytochemicals and Medicinal Plants
- Complement system in diseases
- Geomechanics and Mining Engineering
- Chaos control and synchronization
- Brake Systems and Friction Analysis
- Visual Attention and Saliency Detection
- Chronic Kidney Disease and Diabetes
- Ion Transport and Channel Regulation
- Wireless Power Transfer Systems
- CCD and CMOS Imaging Sensors
Harbin Institute of Technology
2023-2024
Third Xiangya Hospital
2024
Central South University
2024
First Affiliated Hospital of Soochow University
2020-2023
Soochow University
2020-2023
Guilin University of Technology
2021-2023
Tiangong University
2022
Pennsylvania State University
2022
Songshan Lake Materials Laboratory
2022
Huazhong Agricultural University
2020
Natural intelligence has many dimensions, with some of its most important manifestations being tied to learning about the environment and making behavioral changes. In primates, vision plays a critical role in learning. The underlying biological neural networks contain specialized neurons synapses which not only sense process visual stimuli but also learn adapt remarkable energy efficiency. Forgetting an active Mimicking adaptive neurobiological mechanisms for seeing, learning, forgetting...
Transmembrane protease serine 2 (TMPRSS2) is a membrane-bound expressed in many human epithelial tissues, including the airway and lung. TMPRSS2-mediated cleavage of viral spike protein key mechanism severe acute respiratory syndrome coronavirus activation host cell entry. To date, cellular mechanisms that regulate TMPRSS2 activity surface expression are not fully characterized. In this study, we examined two major post-translational events, zymogen N-glycosylation, TMPRSS2. experiments with...
Abstract Acetyl‐11‐keto‐β‐boswellic acid (AKBA), an active triterpenoid compound from the extract of Boswellia serrate, has been reported previously in our group to alleviate fibrosis vascular remodelling. This study aimed elucidate vivo and vitro efficacy mechanism AKBA renal interstitial fibrosis. The experimental was produced C57BL/6 mice via unilateral ureteral obstruction (UUO). Hypoxia‐induced HK‐2 cells were used imitate pathological process vitro. Results showed that treatment...
Type II transmembrane serine proteases (TTSPs) are a group of enzymes participating in diverse biological processes. Some members the TTSP family implicated viral infection. TMPRSS11A is expressed on surface airway epithelial cells, which has been shown to cleave and activate spike proteins severe acute respiratory syndrome (SARS) Middle East coronaviruses (CoVs). In this study, we examined mechanism underlying activation cleavage that converts one-chain zymogen two-chain enzyme. By...
Terminalia chebula (TC), a kind of Combretaceae, is widely used herb in India and East Asia to treat cerebrovascular diseases. However, the potential mechanism neuroprotective effects TC at metabonomics level still not clear. The present study focused on stroke model. Rats were divided randomly into sham, model, groups. group intragastrically administered with for 7 days after middle cerebral artery occlusion (MCAO) operation. sham model groups received vehicle same length time....
The scavenger receptor cysteine-rich (SRCR) domain is a key constituent in diverse proteins. N-glycosylation important protein expression and function. In the SRCR of different proteins, sites functionality vary substantially. this study, we examined importance site positions hepsin, type II transmembrane serine protease involved many pathophysiological processes. We analysed hepsin mutants with alternative domains using three-dimensional modelling, site-directed mutagenesis, HepG2 cell...
Selective protein distribution on distinct plasma membranes is important for epithelial cell function. To date, how proteins are directed to specific surface not fully understood. Here we report a conserved DSSDE motif in LDL-receptor (LDLR) modules of corin (a transmembrane serine protease) and CD320 receptor vitamin B12 uptake), which regulates apical membrane targeting renal cells. Altering this prevents expression polarized Madin-Darby canine kidney (MDCK) Mechanistic studies indicate...
As deep learning technologies advance, increasingly more data is necessary to generate general and robust models for various tasks. In the medical domain, however, large-scale multi-parties training analyses are infeasible due privacy security concerns. this paper, we propose an extendable elastic framework preserve while enabling collaborative with efficient communication. The proposed named distributed Asynchronized Discriminator Generative Adversarial Networks (AsynDGAN), which consists...
Extensive exotic introgression could significantly enlarge the genetic distance of hybrid parental populations to promote strong heterosis. The goal this study was investigate whether genome-wide prediction can support pre-breeding in with introgressions. We evaluated seed yield, yield related traits and quality 363 hybrids Brassica napus (AACC) derived from two divergent on massive species three environments. presented heterosis which much higher than other investigated traits. Five genomic...
Lunar meteorites are the fragments of rocks that fell on Earth because impacts asteroids Moon. Such preserve information about composition, evolutionary process, and shock history lunar surface. NWA 13120 is a recently discovered breccia meteorite having features strong shock, which composed lithic mineral clasts in matrix very fine-grained (<10 μm) recrystallized olivine-plagioclase with poikilitic-like texture. As most abundant clasts, crystalline impact melt (CIM) can be divided into...
Ordinary chondrites are the most common type of chondrites. As a non-destructive, rapid, and semi-quantitative technology, Raman spectroscopy is widely used in geoscience. This paper presents results spectroscopic study that we conducted for 16 ordinary with different chemical groups variable degrees shock metamorphism. We found that: (1) relationship between Fe composition olivine pyroxene characteristic peaks spectrum established by predecessors cannot be refined to range meteorites, on...
Metalized film capacitor (MFC) with ultrahigh power is one of the key devices in High Voltage Direct Current (HVDC) transmission technology, and evaluation its long-term performance (especially lifetime) great importance for reliability HVDC system. But those experiments require enormous supply capacity which difficult to achieve laboratory. In this paper, we propose a feasible equivalent experiment method evaluate MFC, employs floating aging at elevated temperature voltage level imitating...
Abstract Among the novel dihydrofuran derivatives, compound (VII) exhibits highest activity against four human cancer cell lines.
The etching of silicon-based slanted grating based on CHF <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> /O xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> /Ar reactive ion beam (RIBE) is investigated. Impacts the gases flow rate roughness, tilt angle and are studied in detail. It found that when Cr adopted as metal mask, rate, sidewall inclination mesa changed significantly with variation gases. When =5/3/2, a controllable 32.8...
Abstract The study of lunar magma evolution holds significant importance within the scientific community due to its relevance in understanding Moon's thermal and geological history. However, intricate task unraveling history early volcanic activity on Moon is hindered by high flux impactors, which have substantially changed morphology pristine constructs. In this study, we focus a unique glass found meteorite Northwest Africa 11801. This kind bead‐like shape compositionally similar Apollo‐14...