This study aimed to explore the changes of vaginal microbiota and enzymes in women with high-risk human papillomavirus (HR-HPV) infection cervical lesions. A total 448 participants were carried out HPV genotyping, cytology tests, microecology 28 treated as sub-samples, which samples characterized by sequencing bacterial 16S V4 ribosomal RNA (rRNA) gene region. The found prevalence HR-HPV was higher patients BV (P = 0.036). rate 72.73% G. vaginalis women, significantly than that lactobacillus...

Estrogen-related receptor α (ERRα) has been reported to play a critical role in endometrial cancer (EC) progression. However, the underlying mechanism of ERRα-mediated lipid reprogramming EC remains elusive. The transcription factor EB (TFEB)-ERRα axis induces promote progression was explored this study.TFEB and ERRα were analyzed validated by RNA-sequencing data from Cancer Genome Atlas (TCGA). TFEB-ERRα assessed dual-luciferase reporter chromatin immunoprecipitation quantitative polymerase...

This study assessed the predictive value of preoperative systemic immune-inflammatory index (SII) for lymph node metastasis (LNM) in endometrial cancer (EC) patients.We retrospectively included 392 EC patients between January 2013 and 2019. Data on clinical indicators including age, body mass (BMI), menopause, serum inflammatory immune index, tumor markers, history diabetes hypertension, stage, histological type, myometrial invasion (MI) were collected. The association LNM was evaluated.The...

This study aimed to investigate the inflammatory-immune cells in peripheral blood of women with polycystic ovary syndrome (PCOS) and assessed potential correlation between infertility PCOS women.In this case-control study, profiles lymphocyte subsets were analyzed by flow cytometry. White (WBC), neutrophils (Neu), lymphocytes, Ferriman-Gallwey (F-G) score, testosterone, prolactin, follicle-stimulating hormone, luteinizing fasting glucose, plasma insulin measured, together body mass index....

To investigate the relationship between hepatic steatosis index (HSI) and endometrial cancer (EC) its diagnostic value for EC. A total of 114 patients with pathologically diagnosed EC in Mindong Hospital, Ningde City, Fujian Province from 2016 to 2022 were retrospectively included as group. 175 confirmed benign lesions (endometrial polyps uterine submucosal fibroids) same hospital during period selected control Non-parametric test used compare differences HSI non-alcoholic fatty liver...

PGC-1α and ERRα are closely related to tumor formation progression. However, the mechanism underlying involvement of PGC-1α/ERRα in regulating invasion migration endometrial cancer remains be explored.Elevated levels were associated with advanced myometrial invasion, Vimentin expression was depth premenopausal cancer. Silencing reduced activation inhibited epithelial-mesenchymal-transition phenotypes, resulting significant inhibition migration. Overexpression led enhanced increased activity...

Estrogen-related receptor alpha (ERRα) plays an important role in endometrial cancer (EC) progression. However, the biological roles of ERRα EC invasion and metastasis are not clear. This study aimed to investigate 3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1) regulating intracellular cholesterol metabolism promote HMGCS1 interactions were detected by co-immunoprecipitation, effects ERRα/HMGCS1 on investigated wound-healing transwell chamber assays. Cellular content was measured verify...

Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a significant health issue closely associated with multiple extrahepatic cancers. The association between MAFLD and clinical outcomes of endometrial cancer (EC) remains unknown. Methods: We retrospectively included 725 EC patients January 2012 December 2020. odds ratios (ORs) were calculated using logistic regression analyses. Kaplan–Meier survival curves used for analysis. Results: Among patients, the prevalence was...

We investigated the relationship between metabolic syndrome (MetS) and its components erythrocyte parameters such as red blood cell count (RBC) hemoglobin (Hb) levels, their association with risk of deep myometrial invasion in endometrioid endometrial carcinoma (EEC).A total 473 women diagnosed EEC January 2012 December 2018 were included study. MetS was using a modified version Chinese Diabetes Society 2004 criteria. Demographic clinical characteristics stratified by compared. Logistic...

Post-menopausal patients with cervical intraepithelial neoplasia (CIN) have a high rate of residual or recurrent lesions after treatment, and their risk for cancer later in life is higher than the general population. Hence, management this specific group post-menopausal needs more attention.The study aimed to identify factors associated presence disease hysterectomy specimens grade 3 (CIN 3).This was retrospective analysis data from women who had undergone following conization CIN 2012 2018...

<b><i>Objective:</i></b> This study aimed to identify risk factors associated with the presence of positive surgical margins in cervical conization specimens. <b><i>Methods:</i></b> is a retrospective analysis data from women who had undergone for intraepithelial neoplasia (CIN) 2012 2018 at Fujian Maternity and Child Health Hospital. Factors extracted database included age, gravidity, parity, menopausal status, precone Thinprep cytology test,...

Background: The diagnosis of postpartum pelvic organ prolapse (POP) relies on symptoms combined with prolapse-quantification (POP-Q) and lacks serological indicators. objective this study was to assess serum elastin, type I collagen, miRNA-30d, miRNA-181a in the early period identify hematologic predictors POP. Material Methods: included 1013 42- 60-day-postpartum women who had delivered at Quanzhou Women’s Children’s Hospital from October 1, 2016, 31, 2017. This performed accordance...

We aim to investigate the correlation between expression of estrogen-related receptor γ (ERRγ) and endometrial cancer (EC) progression evaluate potential ERRγ as a new biomarker for EC diagnosis. analyzed profile with corresponding clinical characteristics samples from The Cancer Genome Atlas (TCGA), Clinical Proteomic Tumor Analysis Consortium (CPTAC) databases, International (ICGC) databases. Immunohistochemical (IHC) analysis was conducted on tissue samples, enzyme linked immunosorbent...

This study aimed to explore lymphocyte subsets for the personalized prediction of endometrioid endometrial cancer (EEC) risk and evaluated correlation between immune cells International Federation Gynecology Obstetrics (FIGO) staging in patients with EEC.A case-control was conducted analyze clinical data 421 admitted Fujian Maternity Child Health Hospital from October 2017 December 2021. t-tests or Mann-Whitney U-tests were used percentages absolute counts peripheral blood EEC without...

Abstract Background: Endometrial cancer (EC) is one of the most common tumors in women. Estrogen-related receptor α (ERRα) has been reported to play a critical role EC progression. However, underlying mechanism ERRα-mediated lipid reprogramming remains elusive. Here, we show that transcription factor EB (TFEB)-ERRα axis promote enhance invasion and metastasis EC. Methods : TFEB ERRα were analyzed validated by RNA-sequencing data tissues from Cancer Genome Atlas (TCGA). TFEB-ERRα assessed...

Aggregation is a key process for determining the environmental behavior and impact of nanoparticle (NP). Since organophosphate esters (OPEs), which are recognized as emerging contaminants, distributed widely in natural aquatic environment, they may contribute to interacting with NPs ultimately influence their transport fate. Here, we investigated two typical OPEs on aggregation Fe2O3 NP environments. The results showed that both tri-ethylhexyl phosphate (TEHP) tris (chloroisopropyl) (TCPP)...