A5062079293- Endometrial and Cervical Cancer Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Risks and Factors
- Liver Disease Diagnosis and Treatment
- Medicinal Plants and Neuroprotection
- Pelvic floor disorders treatments
- Flavonoids in Medical Research
- Pediatric health and respiratory diseases
- Ovarian cancer diagnosis and treatment
- Sleep and Wakefulness Research
- Traditional Chinese Medicine Analysis
- Cancer, Stress, Anesthesia, and Immune Response
- Chromatin Remodeling and Cancer
- Chronic Kidney Disease and Diabetes
- Peptidase Inhibition and Analysis
- Endometriosis Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Alzheimer's disease research and treatments
- Infant Health and Development
- Cancer survivorship and care
- Medicinal Plant Pharmacodynamics Research
- Natural Antidiabetic Agents Studies
- Rheumatoid Arthritis Research and Therapies
- Metabolomics and Mass Spectrometry Studies
- Cervical Cancer and HPV Research
Tianjin Medical University Cancer Institute and Hospital
2025
Fujian Medical University
2019-2023
China Medical University
2017-2023
Second Affiliated Hospital of Fujian Medical University
2021
This study assessed the predictive value of preoperative systemic immune-inflammatory index (SII) for lymph node metastasis (LNM) in endometrial cancer (EC) patients.We retrospectively included 392 EC patients between January 2013 and 2019. Data on clinical indicators including age, body mass (BMI), menopause, serum inflammatory immune index, tumor markers, history diabetes hypertension, stage, histological type, myometrial invasion (MI) were collected. The association LNM was evaluated.The...
Due to substantial morbidity and complications including nephropathy, a search for alternative treatment of diabetes mellitus is urgently required. The present study aimed investigate the hypoglycemic anti-diabetic nephropathy activities polysaccharides separated from Auricularia auricular (AAP). Diet streptozotocin (STZ)-induced diabetic Sprague-Dawley rats were orally treated with metformin (100 mg/kg; positive control) AAP 400 mg/kg) four weeks, parameters in serum liver associated blood...
Orexins are hypothalamic neuropeptides that regulate feeding, reward, wakefulness and energy homeostasis. The present study sought to characterize the involvement of orexin A in glucose metabolism HepG2 human hepatocellular carcinoma cells, investigated role hypoxia-inducible factor-1α (HIF-1α) response. cells were exposed different concentrations (10-9 10-7 M) vitro, without or with receptor 1 (OX1R) inhibitor (SB334867), HIF-1α (YC-1) a combination both inhibitors. Subsequently, OX1R,...
Scutellarin (SC), mainly extracted from the Chinese herb Erigeron breviscapus (vant.), has been reported to possess various pharmacological activities; however, its effects on Alzheimer's disease (AD) have not systemically reported. The protective of SC AD were investigated using an L‑glutamic acid (L‑Glu)‑damaged HT22 cell apoptosis model and aluminum chloride plus D‑galactose‑induced mouse model. In L‑Glu‑damaged cells, significantly increased viability, inhibited lactate dehydrogenase...
Background: To evaluate the prognostic value of systemic inflammatory score (SIS) in cervical cancer patients.Methods: A total 264 patients with FIGO stage (2009) IB-IIA undergoing radical resection from January 2014 to December 2017 were recruited.The optimal cutoff values for biomarkers calculated by X-tile software.The factors investigated using univariate and multivariate Cox analyses.Time-dependent receiver operating characteristic (time-ROC) analysis concordance index (C-index) used...
Post-menopausal patients with cervical intraepithelial neoplasia (CIN) have a high rate of residual or recurrent lesions after treatment, and their risk for cancer later in life is higher than the general population. Hence, management this specific group post-menopausal needs more attention.The study aimed to identify factors associated presence disease hysterectomy specimens grade 3 (CIN 3).This was retrospective analysis data from women who had undergone following conization CIN 2012 2018...
The aim of the current study was to investigate underlying mechanism S-phase kinase associated protein 2 (Skp2) gene inhibition by lentivirus-mediated RNA interference (RNAi) on cell cycle, apoptosis and proliferation endometrial carcinoma HEC-1-A cells. A lentivirus shRNA vector targeting Skp2 constructed transfected into cells with a scramble sequence were used as negative controls. mRNA expression Skp2, p27, cyclin D1 caspase-3 detected via reverse transcription-quantitative polymerase...
This study was undertaken to determine the astragaloside content in Qishen Huoxue Granule (QHG) by HPLC and investigate protective effect of septic rats.Methods: Dikma Diamonsil TM C 18 column used.Mobile phase methanol: acetonitrile (42:58) detection performed at 205 nm.Healthy rats were randomly divided into three groups, group A: sham operation (SO) group; B: cecal ligation puncture (CLP) C: CLP QHG treatment group.72 h after model establishment, plasma tumor necrosis factor-α (TNF-α),...
Objective: To study the effect of 10-Hydroxycamptothecine (10-HCPT) on proliferation and apoptosis human Fibroblast-like Synoviocyte (FLS) with Rheumatoid Arthritis (RA). Methods: Different concentrations 10-HCPT Methotrexate (MTX) were used to treat FLS cells in RA Osteoarthritis (OA) for different time (24, 48, 72 hours), without MTX served as control group. CCK-8 assay applied determine cells, Annexin-V APC/7-AAD staining detect cells. Results: The survival rate (66.68±0.48) %, 48 h;...