A5024637745- RNA modifications and cancer
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- RNA Research and Splicing
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- IL-33, ST2, and ILC Pathways
- Pharmaceutical Economics and Policy
- Marriage and Family Dynamics
- Xenotransplantation and immune response
- Analytical Chemistry and Chromatography
- Smart Grid Security and Resilience
- Chromosomal and Genetic Variations
- Liver Disease and Transplantation
- Cancer, Lipids, and Metabolism
- Pesticide Residue Analysis and Safety
- Atmospheric chemistry and aerosols
- Mycotoxins in Agriculture and Food
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Burn Injury Management and Outcomes
- Renal Diseases and Glomerulopathies
- Cancer, Hypoxia, and Metabolism
- RNA and protein synthesis mechanisms
Northeast Normal University
2025
Zhongshan Hospital of Xiamen University
2024
Sichuan University
2018-2024
Boston Children's Hospital
2022-2024
Harvard University
2024
Center for Life Sciences
2023-2024
Tsinghua University
2023-2024
Peking University
2024
Fujian Medical University
2018-2022
Boston Children's Museum
2022
Gene therapy using hematopoietic stem and progenitor cells is altering the therapeutic landscape for patients with hematologic, immunologic, metabolic disorders but has not yet been successfully developed individuals bone marrow failure syndrome Diamond-Blackfan anemia (DBA). More than 30 mutations cause DBA through impaired ribosome function lead to inefficient translation of erythroid master regulator GATA1, providing a potential avenue intervention applicable all DBA, irrespective...
Decreasing precipitation frequency (DPF) has the potential to alter soil microbial community structure, enzyme activity, and stoichiometry of biomass in grassland ecosystems. Grasslands have undergone degradation, often driven by anthropogenic activities such as overgrazing, which further intensifies their sensitivity environmental changes altered precipitation. Changes communities can turn impact organic carbon pool (SOCP) its stability, particularly degraded grasslands shaped agricultural...
Objective To investigate the epidemiological profile and associated outcomes of electrical injuries at a major burn centre in southern China. Methods This retrospective study enrolled consecutive patients admitted to First Affiliated Hospital Guangxi Medical University between 2008 2017. Demographic clinical data were recorded. Mann–Whitney U tests/Pearson’s chi-squared tests used examine differences low-voltage high-voltage injuries. Results There 217 159 High-voltage burns frequently...
Stem cells can undergo continuous self-renewal and meanwhile retain the stemness capability to differentiate mature functional cells. However, it is unclear whether proliferation property be segregated from in stem The intestinal epithelium undergoes fast renewal, Lgr5+ (ISCs) are essential maintain homeostasis. Here, we report that methyltransferase-like 3 (Mettl3), a critical enzyme for N6-methyladenosine (m6A) methylation, required ISCs maintenance as its deletion results loss of markers...
Abstract Intestinal epithelial cells (IECs) are pivotal for maintaining intestinal homeostasis through self-renewal, proliferation, differentiation, and regulated cell death. While apoptosis necroptosis recognized as distinct pathways, their intricate interplay remains elusive. In this study, we report that Mettl3 -mediated m 6 A modification maintains by impeding knockout induces both in IECs. Targeting different modes of death with specific inhibitors unveils RIPK1 kinase activity is...
Novel endocrine therapeutic strategy in endometrial carcinoma targeting estrogen-related receptor alpha by XCT790 and siRNA PengMing Sun,1,* XiaoDan Mao,1,* Min Gao,2 MeiMei Huang,1 LiLi Chen,1 GuanYu Ruan,1 WeiYi Elena Ioana Braicu,3 Jalid Sehouli3 1Laboratory of Gynecologic Oncology, Fujian Provincial Maternity Children's Hospital, Affiliated Hospital Medical University, Fuzhou 350001, People's Republic China; 2Department Gynecology Beijing Cancer 100142, 3Department Gynecology, Campus...
Endometrial cancer (EC) is a hormone dependent carcinoma that may involve complex molecular mechanisms. Endocrine therapy by blocking the estrogen and receptor α (ERα) has been effective in breast cancer, while it still controversial EC. Recently, estrogen-related (ERRα) was proven to be another endocrine target.The anti-tumor effect of selective modulators (SERMs) XCT790 (XCT) used alone or combination were evaluated both ERα-positive (ERα+) ERα-negative (ERα-) EC cells. ERα ERRα mRNA...
PGC-1α and ERRα are closely related to tumor formation progression. However, the mechanism underlying involvement of PGC-1α/ERRα in regulating invasion migration endometrial cancer remains be explored.Elevated levels were associated with advanced myometrial invasion, Vimentin expression was depth premenopausal cancer. Silencing reduced activation inhibited epithelial-mesenchymal-transition phenotypes, resulting significant inhibition migration. Overexpression led enhanced increased activity...
Using a simple and efficient single sperm PCR direct sequencing method, we screened for HLA-DPBl gene mutations that may give rise to new alleles at this highly polymorphic locus. More than 800 were studied from heterozygous individual whose two carried 16 nucleotide sequence differences clustered in six regions. A potential microgene conversion event was detected. Unrepaired heteroduplex DNA similar which gives postmeiotic segregation events yeast observed three cases. Control experiments...
A higher prevalence of anti-hepatitis E virus (HEV) in non-endemic viral hepatitis such as Germany has been reported our previous study. The aim this study was to assess the seroepidemiology HEV among haemodialysis (HD) patients Shin-Kong Hospital, Taiwan, and evaluate whether there an increased risk infection exposure even area endemic hepatitis.Serum samples obtained from 400 Taiwanese on chronic HD (group 1), sex- age-matched healthy subjects 2) hospital 3) were tested for IgG...
To investigate the effect of neoadjuvant chemotherapy in patients with advanced vulvar cancer and to provide references for clinical treatment. Clinical pathological data 12 carcinoma were collected. The response operability rates, adverse effects, prognosis retrospectively analyzed. mean patient age was 45.8 (range 26–69) years. Among patients, 9 underwent treatment bleomycin cisplatin or without vincristine. overall rate 67%. Five (56%) experienced grade 1 2 bone marrow suppression...
Two transcriptional factors, peroxisome proliferator-activated receptor-γ (PPARγ) and estrogen-related receptor-α (ERRα), have been reported to be key regulators of cellular energy metabolism. However, the relationship between ERRα PPARγ in development endometrial cancer (EC) is still unclear. The expression levels EC were evaluated by quantitative real-time PCR, western blot, tissue array immunohistochemistry. A significant negative correlation was identified women with (ρ=-0.509, P<0.001)....
Ovarian cancer (OC) metastasis presents major hurdles that must be overcome to improve patient outcomes.Recent studies have demonstrated copy number variations (CNVs) frequently contribute alterations in oncogenic drivers.The present study used a CytoScan HD Array analyse CNVs and loss of heterozygosity (LOH) the entire genomes 6 OC patients human cell lines determine genetic target events leading distinct invasive/migratory capacities OC.The results showed LOH at Xq11.1 Xp21.1 gains 8q21.13...
We aim to investigate the correlation between expression of estrogen-related receptor γ (ERRγ) and endometrial cancer (EC) progression evaluate potential ERRγ as a new biomarker for EC diagnosis. analyzed profile with corresponding clinical characteristics samples from The Cancer Genome Atlas (TCGA), Clinical Proteomic Tumor Analysis Consortium (CPTAC) databases, International (ICGC) databases. Immunohistochemical (IHC) analysis was conducted on tissue samples, enzyme linked immunosorbent...
Surface ozone (O3) pollution has become one of the top environmental issues in recent years around world and can be influenced by meteorological processes on multiple scales. Understanding mechanism contributions O3 is great importance for mitigation. In this study, we explored impacts conditions concentrations a coastal city Southeast China, with particular focus episodes inspringtime. A significant increase ratefrom 2015 to 2020 was observed (41.7% year−1) seasonal characteristics showed...
Choriocarcinoma is an aggressively invasive neoplasm, characterized by its rapid proliferation and propensity for metastasis to distant organs via hematogenous dissemination. Lungs (80%), vagina (30%), pelvis (20%), liver (10%), brain (10%) are the most frequently metastasized organs. Renal metastases very rare. The clinical manifestations of choriocarcinoma varies depending on site disease, making diagnosis challenging. In this report, we provide a case with renal pulmonary systems,...
Abstract The occurrence of power grid blackout will cause major production equipment damage, economic losses, or even casualties in some extremely serious cases. It is necessary to upgrade the technology traditional so that emergency measures can be taken when unexpected cascade failure occurs. In this work, an active warning probability model proposed for smart system. First, probabilistic evaluation system performance carried out generate historical database required by state. Then,...
e19741 Background: Cystatin C (CysC) has been demonstrated as a new marker of glomerular filtration rate. This study compared the differences between eGFR calculated by Cockcroft&Gault' (eGFRCG) and CysC-based formula (eGFRCysC) in monitoring renal function patients with small-call lung cancer (SCLC) during chemotherapy. Methods: Besides disease-specific parameters, serum creatinine CysC were detected 61 patients, eGFRCG eGFRCysC after each chemotherapy cycle analyzed. Patients also within...