A5071648273- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Metastasis and carcinoma case studies
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Screening and Detection
- Gastrointestinal Tumor Research and Treatment
- Esophageal Cancer Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Cancer Treatment and Pharmacology
- Genetic factors in colorectal cancer
- Multiple and Secondary Primary Cancers
- Colorectal and Anal Carcinomas
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Esophageal and GI Pathology
- Pelvic and Acetabular Injuries
- Economic and Financial Impacts of Cancer
- Enhanced Recovery After Surgery
- Abdominal Trauma and Injuries
- Trauma and Emergency Care Studies
Leiden University Medical Center
2016-2023
Leiden University
2018-2021
Institute of American Indian Arts
2019
•Overall survival remained not significantly different between post-operative CT and CRT in the updated ITT analysis.•Post-operative compliance was poor; about 60% of patients started allocated treatment.•In per-protocol analysis, group had a better 5-year overall survival.•More peritoneal metastases were observed group. BackgroundThe Intergroup 0116 MAGIC trials changed clinical practice for resectable gastric cancer Western world. In these trials, improved with chemoradiotherapy (CRT)...
Studies investigating the association between hospital volume and quality of gastric cancer surgery are lacking. In present study, effect on was evaluated by analysing data from CRITICS (ChemoRadiotherapy after Induction chemotherapy Cancer Stomach) trial.Patients who underwent gastrectomy with curative intent in Netherlands were selected trial database. Annual participating centres derived Registry. Hospital categorized into very low (1-10 gastrectomies per year institution), (11-20),...
Objective: We examined the association between surgical hospital volume and both overall survival (OS) disease-free (DFS) using data obtained from international CRITICS (ChemoRadiotherapy after Induction chemotherapy In Cancer of Stomach) trial. Summary Background Data: trial, patients with resectable gastric cancer were randomized to receive preoperative followed by adequate gastrectomy either or chemoradiotherapy. Methods: Patients in trial who underwent a curative intent Dutch included...
Objective: The purpose of this study was to evaluate surgicopathological quality and protocol adherence for lymphadenectomy in the CRITICS trial. Summary Background Data: Surgical assurance is a key element multimodal studies gastric cancer. In multicenter trial (ChemoRadiotherapy after Induction chemotherapy Cancer Stomach), patients with resectable cancer were randomized preoperative chemotherapy, followed by gastrectomy D1+ (removal stations 1 9 11), either or chemoradiotherapy. Methods:...
The optimal treatment strategy for older rectal cancer patients remains unclear. current study aimed to compare and survival of aged 80+.Patients ≥80 years diagnosed with between 2001 2010 were included. Population-based cohorts from Belgium (BE), Denmark (DK), the Netherlands (NL), Norway (NO) Sweden (SE) compared side by neighbouring countries on 5-year relative (RS), adjusted sex age. Analyses performed separately stage I-III IV patients.Overall, 19 634 For patients, RS varied 61.7% in BE...
Colon cancer in older patients represents a major public health issue. As are hardly included clinical trials, the optimal treatment of these remains unclear. The present international EURECCA comparison explores possible associations between and survival outcomes elderly colon patients.National data from Belgium, Denmark, Netherlands, Norway, Sweden were obtained, as well multicenter surgery cohort Germany. Patients aged 80 years older, diagnosed with 2001 2010, included. study interval was...
Objective: Compare oncological long-term and short-term outcomes between patients with distal cT2NO rectal cancer treated chemoradio-therapy local excision (CRT + LE) total mesorectal (TME). Summary Background Data: Previous studies showed that CRT LE is equivalent to TME in tumor control survival for T2N0 cancer. Methods: Seventy-nine cT2N0 adenocarcinoma the ACOSOG Z6041 trial were compared a cohort of 79 pT2N0 tumors upfront Dutch trial. Survival, outcomes, health-related quality life...
Background: In the randomized Asian REGATTA trial, no survival benefit was shown for additional gastrectomy over chemotherapy alone in patients with advanced gastric cancer a single incurable factor, thereby discouraging surgery these patients.The purpose of this study to evaluate treatment strategies metastatic daily practice five European countries, along relative each country.Methods: Nationwide population-based data from Belgium, Denmark, Netherlands, Norway and Sweden were...
BackgroundMortality in the first postoperative year represents an accurate reflection of perioperative risk after colorectal cancer surgery. This research compares one-year mortality surgery divided into three age-categories (18-64, 65-74, ≥75 years), focusing on time trends and comparing treatment strategies.MaterialPopulation-based data all patients diagnosed treated surgically for stage I-III primary from 2007 to 2016, were collected Belgium, Netherlands, Norway, Sweden. Stratified...
Preoperative randomization for postoperative treatment might affect quality of surgery. In the CRITICS trial (ChemoRadiotherapy after Induction chemotherapy Cancer Stomach), patients were randomized before to receive prior a D1 + gastrectomy (removal lymph node station (LNS) 1–9 11), followed by either (CT) or chemoradiotherapy (CRT). this analysis, influence upfront on surgery was evaluated. Quality analyzed in both study arms using surgicopathological compliance ≥ 15 nodes), surgical...