A5038622835- Probiotics and Fermented Foods
- Microplastics and Plastic Pollution
- Gut microbiota and health
- Nanoparticles: synthesis and applications
- Polymer Surface Interaction Studies
- Membrane Separation Technologies
- Microbial Metabolites in Food Biotechnology
- Gastrointestinal motility and disorders
- Recycling and Waste Management Techniques
- biodegradable polymer synthesis and properties
- Biochemical and Structural Characterization
- Helicobacter pylori-related gastroenterology studies
- Microfluidic and Bio-sensing Technologies
- Bacterial biofilms and quorum sensing
- Enterobacteriaceae and Cronobacter Research
- Surface Modification and Superhydrophobicity
- Microbial Inactivation Methods
- Electrohydrodynamics and Fluid Dynamics
- Infant Health and Development
- GABA and Rice Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Glycosylation and Glycoproteins Research
- Electrospun Nanofibers in Biomedical Applications
- Effects and risks of endocrine disrupting chemicals
- Biochemical effects in animals
Université de Toulouse
2014-2025
Université Toulouse III - Paul Sabatier
2014-2025
Toxalim Research Centre in Food Toxicology
2016-2025
École Nationale Vétérinaire de Toulouse
2016-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021-2025
Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés
2007-2024
Microbiologie de l’alimentation au service de la santé
2014-2017
Centre National de la Recherche Scientifique
2006-2016
Institut National des Sciences Appliquées de Toulouse
1998-2016
Institut National Polytechnique de Toulouse
2010-2015
Despite well-known intestinal epithelial barrier impairment and visceral hypersensitivity in irritable bowel syndrome (IBS) patients IBS-like models, structural physical changes the mucus layer remain poorly understood. Using a water avoidance stress (WAS) model, we aimed at evaluating whether 1) WAS modified gut permeability, sensitivity, mucin expression, biochemical structure of O-glycans, related properties, 2) Lactobacillus farciminis treatment prevented these alterations. Wistar rats...
The colonic mucus barrier is commonly described as a continuous double layer covering the epithelium, separating microbiota from intestinal tissue. This model currently considered valid throughout colon. colon characterised by regional anatomo-functional specificities such presence and consistency of contents location. In this study, we organisation in proximal distal rodents histological FISH staining, taking into account aforementioned specificities. By using longitudinal sections imaging...
Correlative microscopy combining various imaging modalities offers powerful insights into obtaining a comprehensive understanding of physical, chemical, and biological phenomena. In this article, we investigate two approaches for image fusion in the context inherently lower-resolution chemical images obtained using secondary ion mass spectrometry (SIMS) with high-resolution ultrastructural electron (EM). We evaluate methods three different case studies selected to broadly represent typical...
Perfluorooctanoic acid (PFOA) is a synthetic perfluorinated chemical classified as persistent organic pollutant. PFOA has been linked to many toxic effects, including liver injury. Many studies report that exposure alters serum and hepatic lipid metabolism. However, lipidomic pathways altered by are largely unknown only few classes, mostly triacylglycerol (TG), usually considered in analysis. Here, we performed global analysis on the of PFOA-exposed (high-dose short-duration) control mice...
Titanium dioxide (TiO2) is commonly used as a food additive (E171 in the EU) for its whitening and opacifying properties. However, risk of intestinal barrier disruption, including dysbiosis gut microbiota, increasingly suspected because presence nano-sized fraction this additive. We hypothesized that food-grade E171 Aeroxyde P25 (identical to NM-105 OECD reference nanomaterial European Union Joint Research Centre) interact with both commensal bacteria transient food-borne under...
Titanium dioxide (TiO2) particles are commonly used as a food additive (E171 in the EU) for its whitening and opacifying properties. However, risk of gut barrier disruption is an increasing concern because presence nano-sized fraction. Food-grade E171 may interact with mucus, protagonist still poorly explored nanotoxicology. To test this hypothesis, comprehensive approach was performed to evaluate vitro vivo interactions between TiO2 intestinal by comparing food-grade NM-105 (Aeroxyde P25)...
Gut disorders associated to irritable bowel syndrome (IBS) are combined with anxiety and depression. Evidence suggests that microbially produced neuroactive molecules, like γ-aminobutyric acid (GABA), can modulate the gut-brain axis. Two natural strains of Lactococcus lactis one mutant were characterized in vitro for their GABA production tested vivo rat by oral gavage antinociceptive properties. L. NCDO2118 significantly reduced visceral hypersensitivity induced stress due its glutamate...
Abstract Irritable bowel syndrome (IBS) is a multifactorial disorder of the gut‐brain axis, characterized by visceral hypersensitivity (VH). Psychobiotics, through GABA synthesis, are good candidates to alleviate gastrointestinal discomfort. Here, we analyzed GABA‐producer Lactococcus lactis CNCM I‐5388 as an active‐enzyme postbiotic relieve VH mediated psychological stress. L. was inactivated ethanol while maintaining its glutamate decarboxylase (GAD) activity. This EtOH‐treated nonviable...
Marine plastic pollution poses significant risks to ecosystems and human health, particularly in vulnerable Arctic regions. Therefore, assessing the extent impacts of contamination these regions through a One Health framework is essential for developing strategies build resilience populations ecosystems. The Horizon Europe ICEBERG Project addresses challenges at ocean-coast-land continuum, working partnership with Indigenous peoples local communities south Greenland, northwest Iceland,...
The “Plastics, Environment and Health” research network (groupement de recherche, GDR) created in 2019 gathers the French scientific community working on plastic pollution all environments (soil, air, water) their impact ecosystems human health. objective is to rapidly increase knowledge by supporting collaboration of researchers from different fields such as ecotoxicology, chemistry, physics, microbiology, oceanography social science. Research carried out at each stage life cycle, (from...
Adhesion of bacteria to mucus may favor their persistence within the gut and beneficial effects host. Interactions between pig gastric mucin (PGM) a natural isolate Lactococcus lactis (TIL448) were measured at single-cell scale under static conditions, using atomic force microscopy (AFM). In parallel, these interactions monitored bacterial population level shear flow. AFM experiments with L. cell-probe PGM-coated surface revealed high proportion specific adhesive events (60%) low...