A5075453232- Advanced MRI Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Blood properties and coagulation
- Advanced Neuroimaging Techniques and Applications
- Erythrocyte Function and Pathophysiology
- MRI in cancer diagnosis
- Barrier Structure and Function Studies
- Cerebrovascular and Carotid Artery Diseases
- Functional Brain Connectivity Studies
- Cardiovascular Health and Disease Prevention
- Optical Imaging and Spectroscopy Techniques
- Lipid metabolism and disorders
- Cerebrospinal fluid and hydrocephalus
- 3D Printing in Biomedical Research
- Mathematical Biology Tumor Growth
- Alzheimer's disease research and treatments
- Acute Ischemic Stroke Management
- Polymer Surface Interaction Studies
- Rheology and Fluid Dynamics Studies
- NMR spectroscopy and applications
- Fluid Dynamics and Turbulent Flows
- Microfluidic and Bio-sensing Technologies
- Bacterial biofilms and quorum sensing
- Frailty in Older Adults
- Intracranial Aneurysms: Treatment and Complications
Institut de Mécanique des Fluides de Toulouse
2014-2024
Université de Toulouse
2012-2024
Centre National de la Recherche Scientifique
2012-2024
Institut National Polytechnique de Toulouse
2009-2024
Hospices Civils de Lyon
2012-2022
Centre National pour la Recherche Scientifique et Technique (CNRST)
2021-2022
Cornell University
2017-2019
Université Toulouse III - Paul Sabatier
2004-2017
Hôpital Femme Mère Enfant
2009
Aging or cerebral diseases may induce architectural modifications in human brain microvascular networks, such as capillary rarefaction. Such limit blood and oxygen supply to the cortex, possibly resulting energy failure neuronal death. Modelling is key understanding how these affect flow mass transfers complex networks. However, huge number of vessels brain-tens billions-prevents any modelling approach with an explicit representation down scale capillaries. Here, we introduce a hybrid model...
Despite the key role of capillaries in neurovascular function, a thorough characterization cerebral capillary network properties is currently lacking. Here, we define range metrics (geometrical, topological, flow, mass transfer, and robustness) for quantification structural differences between brain areas, organs, species, or patient populations and, parallel, digitally generate synthetic networks that replicate organizational features anatomical (isotropy, connectedness, space-filling...
Abstract Blood microcirculation supplies neurons with oxygen and nutrients, contributes to clearing their neurotoxic waste, through a dense capillary network connected larger tree-like vessels. This complex microvascular architecture results in highly heterogeneous blood flow travel time distributions, whose origin consequences on brain pathophysiology are poorly understood. Here, we analyze highly-resolved intracortical transport simulations establish the physical laws governing macroscopic...
The physics of blood flow in small vessel networks is dominated by the interactions between Red Blood Cells (RBCs), plasma and walls. resulting couplings microvessel network architecture heterogeneous distribution RBCs at network-scale are still poorly understood. main goal this paper to elucidate how a local effect, such as RBC partitioning individual bifurcations, interacts with global structure field induce specific preferential locations model microfluidic networks. First, using...
Despite the development of microfluidics, experimental challenges are considerable for achieving a quantitative study phase separation, i.e., non-proportional distribution Red Blood Cells (RBCs) and suspending fluid, in microfluidic bifurcations with channels smaller than 20 μm. Yet, basic understanding separation such small vessels is needed coupling between microvascular network architecture dynamics at larger scale. Here, we present methodologies measurement techniques developed that...
The adult vasculature is comprised of three distinct compartments: the arteries, which carry blood away from heart and display a divergent flow pattern; capillaries, where oxygen nutrient delivery to tissues, as well metabolic waste removal, occurs; veins, back are characterized by convergent pattern. These compartments organized in series regard flow, proceeds upstream arteries downstream veins through capillaries. However, spatial organization more complex, may often be found paralleling...
Preterm kidney is exposed to various exogenous factors that may impact its function such as nephrotoxic drugs or nephrocalcinosis. We investigated prevalence and risk of nephrocalcinosis (NC) in recently born very low birth weight (VLBW) infants submitted improved biological monitoring.Retrospective, case-control study preterm (< 32 + 6 weeks, ≤ 1500 g) admitted a tertiary care unit during 6-year period. Each case (ultrasound-diagnosed NC) was matched with two controls (no NC). Data were...
Brain clearance
Abstract Frailty is a geriatric syndrome that combines physiological decline, disruptions of homeostatic mechanisms across multiple physiologic systems and thus, strong vulnerability to further pathological stress. Previously, we provided the first evidence increased risk poor health outcomes, as quantified by frailty index (FI), associated with an alteration central nervous system (CNS) biomechanical response blood pulsatility. In this study, explored correlation between 14 biological...