A5074822308- Probiotics and Fermented Foods
- Gut microbiota and health
- Inflammatory Bowel Disease
- Pharmacological Effects of Natural Compounds
- Escherichia coli research studies
- Reproductive tract infections research
- Antifungal resistance and susceptibility
- Mycotoxins in Agriculture and Food
- Biochemical effects in animals
- Mycobacterium research and diagnosis
- GABA and Rice Research
- Plant and fungal interactions
- Adipose Tissue and Metabolism
- Clostridium difficile and Clostridium perfringens research
- Stress Responses and Cortisol
- Urinary Tract Infections Management
- Regulation of Appetite and Obesity
- Oral microbiology and periodontitis research
- Helicobacter pylori-related gastroenterology studies
- Microbial Metabolites in Food Biotechnology
- Diet and metabolism studies
- Genomics and Phylogenetic Studies
- Agricultural safety and regulations
- Microbial Metabolism and Applications
- Phytoestrogen effects and research
Lesaffre (France)
2014-2025
Laboratoire de Mécanique des Fluides de Lille - Kampé de Fériet
2011
Vulvovaginal candidiasis is the most prevalent vaginal infection worldwide and Candida albicans its major agent. characterized by disruption of microbiota composition, as happens following large spectrum antibiotic usage. Recent studies support effectiveness oral local probiotic treatment for prevention recurrent vulvovaginal candidiasis. Saccharomyces cerevisiae a safe yeast used as, or for, production ingredients human nutrition health. Here, we demonstrate that administration live (GI)...
Introduction Derivatives from Saccharomyces cerevisiae yeast including extracts and cell walls are sustainable sources of valuable nutrients, dietary fibers proteins. Previous studies have shown that certain components these derivatives can inhibit the growth harmful intestinal bacteria promote beneficial bacteria. However, effects on oral health not yet been investigated. Methods An in vitro biofilm model was employed to examine impacts microbiota their potential benefits for maintaining...
Abstract Irritable bowel syndrome (IBS) is a multifactorial disorder of the gut‐brain axis, characterized by visceral hypersensitivity (VH). Psychobiotics, through GABA synthesis, are good candidates to alleviate gastrointestinal discomfort. Here, we analyzed GABA‐producer Lactococcus lactis CNCM I‐5388 as an active‐enzyme postbiotic relieve VH mediated psychological stress. L. was inactivated ethanol while maintaining its glutamate decarboxylase (GAD) activity. This EtOH‐treated nonviable...
Strategies against the opportunistic fungal pathogen Candida albicans based on probiotic microorganisms represent a promising alternative to traditional antifungals. Here, we investigated effects of Lactobacillaceae isolates from fermented foods or human vagina, alone in combination with yeast Saccharomyces cerevisiae CNCM I-3856, C. vitro. Nine out nineteen tested strains inhibited growth inhibition zones 1-3 mm spot assays. Five lactobacilli as such S. I-3856 also significantly hyphae...
Previously we demonstrated that the treatment with live Saccharomyces cerevisiae exerts beneficial therapeutic effects against vaginal candidiasis. Here, address potential mechanisms particularly examining probiotic capacity to modulate both fungus and host-related factors. We show S. cerevisiae-based markedly affects expression of virulence traits Candida albicans such as aspartyl proteinases (SAPs) well hyphae-associated proteins Hwp1 Ece1 in cavity. On host side, suppression influx...
In this study, we demonstrate, for the first time, that Saccharomyces cerevisiae-based probiotic shows an inhibitory effect on Gardnerella vaginalis infection. This is likely due to several actions: direct interference with adherence vaginal tissues, inhibition of sialidase activity, reduction epithelial exfoliation. does not induce inflammation and no inflammatory cytokines were, indeed, produced, by mouse vagina, neither probiotic. Collectively, our data incite further investigations...
Abstract Background Enterotoxigenic Escherichia coli (ETEC) substantially contributes to the burden of diarrheal illnesses in developing countries. With use complementary vitro models human digestive environment, TNO gastrointestinal model (TIM-1), and Mucosal Simulator Human Intestinal Microbial Ecosystem (M-SHIME), we provided first detailed report on spatial-temporal modulation ETEC H10407 survival, virulence, its interplay with gut microbiota. These systems integrate main physicochemical...
Enterotoxigenic Escherichia coli (ETEC) is one of the most common causes acute traveler's diarrhea. Adhesins and enterotoxins constitute major ETEC virulence traits. With dramatic increase in antibiotic resistance, probiotics are considered a wholesome alternative to prevent or treat infections. Here, we examined antimicrobial properties probiotic Saccharomyces cerevisiae CNCM I-3856 against H10407 pathogenesis upon co-administration TNO gastrointestinal Model (TIM-1), simulating...
The aim of this paper was to evaluate the capacity several yeast-based products, derived from baker's and brewer's yeasts, sequester mycotoxin ochratoxin A (OTA) decrease its rate absorption DNA adduct formation in vivo. experimental protocol included vitro binding studies using isotherm models, vivo chicken experiments, which serum tissue concentrations OTA were analysed absence presence test compounds, profile OTA-derived metabolites their associated adducts determined. Additionally cell...
Abstract Background and Aims The identification of Crohn's disease (CD)‐associated adherent invasive Escherichia coli (AIEC) is time‐consuming requires ileal biopsies. We aimed to identify a faster less methods detect colonization by AIEC in CD patients. Methods patients requiring ileo‐colonoscopy were consecutively enrolled this prospective multicenter study. Samples from saliva, serum, stools, biopsies collected. Results Among 102 patients, the prevalence on was 24.5%. abundance global...
Bacterial vaginosis (BV) is characterized by the presence of a polymicrobial biofilm where Gardnerella vaginalis plays key role. Previously, we demonstrated that Saccharomyces cerevisiae CNCM (French National Collection Cultures Microorganisms) I-3856 helpful in resolving experimental simulated BV mice. In this study, analyzed its capacity to affect G. biofilms and potentiate activity standard antimicrobial agents. We also investigated anti-biofilm Lacticaseibacillus rhamnosus GG (ATCC...
How to define and promote a healthy state of the vaginal microbiome is not well understood. Knowledge which underlying factors shape microbial community composition vagina how modulate them will contribute disease prevention improve fertility.
Saccharomyces cerevisiae (SC), a yeast with an extensive history in food and beverage fermentations, is increasingly acknowledged for its multifaceted application promoting benefiting all aspects of ‘One Health’ approach, including the prevention control zoonoses. For instance, SC contributes to environmentally sustainable agricultural practices through reduced use toxic agents, thus minimizing air soil pollution while enhancing crop quality. Additionally, this versatile can improve health...
The methanogenic strain Mx-05T was isolated from the human fecal microbiome. A phylogenetic analysis based on 16S rRNA gene and protein marker genes indicated that is affiliated with order Methanomassiliicoccales. It shares 86.9% sequence identity Methanomassiliicoccus luminyensis, only member of this previously isolated. cells were non-motile cocci, a diameter range 0.4-0.7 μm. They grew anaerobically reduced methanol, monomethylamine, dimethylamine, trimethylamine into methane, using H2 as...
Oropharyngeal candidiasis is a common opportunistic mucosal infection of the oral cavity, mainly caused by an overgrowth Candida albicans. This can inhibit nutritional intakes and strongly affect quality life. To date, standard therapeutic strategies involving administration antifungal drugs bring several side-effects, not least emergence drug-resistant strains. The purpose this study to investigate effectiveness Saccharomyces cerevisiae CNCM I-3856 (live or inactivated cells) against...
Pharmabiotics and probiotics in current use or under development belong to 2 of 3 domains life, Eukarya (eg, yeasts) Bacteria lactobacilli). Archaea constitute a third domain are currently not used as probiotics, despite several interesting features. This includes the absence known pathogens humans, animals, plants existence some archaea closely associated humans various microbiomes. We promote concept that specific naturally thrive human gut potential next-generation can be rationally...
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by its main symptom, visceral hypersensitivity (VH), which aggravated stress. Gut-brain interactions and gut bacteria may alleviate IBS symptoms, including VH. γ-amino butyric acid (GABA), produced notably lactic (LAB), shows promising result in symptoms treatment. In bacteria, GABA generated through glutamate decarboxylase (GAD) metabolism of L-glutamic acid, maintaining intracellular pH. mammals, acts as...
ABSTRACT Inflammatory bowel diseases (IBD), such as Crohn’s disease and ulcerative colitis, have a complex multifactorial pathogenesis that remains not fully elucidated. Recent research suggests intestinal fungal dysbiosis may contribute to the development persistence of IBD. In this study, we explored, for first time, effects glucocorticoid-induced leucine zipper (GILZ) protein, known protective on gut mucosa in preclinical IBD models, combination with yeast extract, which supports growth...