A5016413904- COVID-19 Clinical Research Studies
- Platelet Disorders and Treatments
- Cardiac Ischemia and Reperfusion
- Adipose Tissue and Metabolism
- Antiplatelet Therapy and Cardiovascular Diseases
- Autophagy in Disease and Therapy
- Cardiovascular Health and Risk Factors
- Fuzzy Logic and Control Systems
- Phosphodiesterase function and regulation
- Vitamin C and Antioxidants Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- High Altitude and Hypoxia
- Venous Thromboembolism Diagnosis and Management
- Cancer, Hypoxia, and Metabolism
- Evolutionary Algorithms and Applications
- Cardiovascular Function and Risk Factors
- Reproductive Health and Contraception
- Genetics and Physical Performance
- Adenosine and Purinergic Signaling
- Biomarkers in Disease Mechanisms
- Pancreatitis Pathology and Treatment
- Pharmacological Effects of Natural Compounds
- Cell death mechanisms and regulation
- Pharmacology and Obesity Treatment
- Tryptophan and brain disorders
Universidad Complutense de Madrid
2019-2024
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2021-2024
(1) Background: This study aimed to analyze if the serum albumin levels of hospitalized SARS-CoV-2 (COVID-19) patients on admission could predict <30 days in-hospital all-cause mortality, and glucose affected this predictive ability. (2) Methods: A multicenter retrospective cohort 1555 COVID-19-infected adult from public hospitals Madrid community were analyzed. (3) Results: Logistic regression analysis showed increased mortality for ages higher than 49 y. After adjusting age, comorbidities...
Mitochondria have been involved in host defense upon viral infections. Factor Xa (FXa), a coagulating factor, may also influence on mitochondrial functionalities. The aim was to analyze if human pulmonary microvascular endothelial cells (HPMEC), the SARS-CoV-2 (COVID-19) spike protein subunits, S1 and S2 (S1+S2), could alter metabolism what is role of FXA. HPMEC were incubated with without recombinants S1+S2 (10 nmol/L each). In control conditions, failed modify FXa expression. However, LPS...
(1) Background: Artificial intelligence using machine learning techniques may help us to predict and prevent obesity. The aim was design an interpretable prediction algorithm for overweight/obesity risk based on a combination of different techniques. (2) Methods: 38 variables related sociodemographic, lifestyle, health aspects from 1179 residents in Madrid were collected used train predictive models. Accuracy, precision, recall metrics tested compared between nine classical the model those...
Purpose Combination of Rivaroxaban plus Aspirin improved cardiovascular outcome in patients with stable disease. The aim was to determine if and acetylsalicylic acid alone or combination may protect mitochondrial mitophagy human coronary artery endothelial cells (HCAEC) exposed D-glucose. Methods HCAEC were incubated under different conditions: 5 mmol/L glucose D-glucose (control), 30 D-Glucose without 50 nmol/L (Rivaroxaban), 0.33 ASA (ASA) (12.5 nmol/L)+ASA (0.33 mmol/L; (Riva+ASA)....
Mitochondria dynamic is regulated by different proteins, maintaining a balance between fission and fusion. An imbalance towards mitochondrial has been associated with tumor cell proliferation. The aim of this study was to analyze whether pectin modifies the viability human colon cancer cells expression proteins involved in fusion fission. carcinoma line HT29 growth 10% fetal bovine serum absence presence pectin. Pectin reduced concentration-dependent manner, reaching plateau at 150~300...
(1) Background: In this work, we aim to describe influenza vaccine uptake among the diabetic population in Spain assess time trend from 2011 2020 and identify predictors of diabetes patients. (2) Methods: We conducted a descriptive cross-sectional study using European Health Interview Survey for (2014 2020) Spanish National Surveys (2011 2017). The independent variables analysed included socio-demographic characteristics, health-related lifestyle variables. matched each participant with...
Long-term therapy with low Aspirin (ASA) dose is basis to prevent thrombotic acute events. However, the anti-platelet mechanisms of ASA remain not completely known. The aim was analyze if in vitro exposure human megakaryocytes concentration may alter apoptotic features newly formed platelets. Cultured Meg-01 cells, a megakaryoblastic cell line, were stimulated form platelets 10 nmol/L phorbol 12-myristate-13-acetate (PMA) presence and absence (0.33 mmol/L). Results revealed that...
<p class="first" dir="auto" id="d1619324e159">Low dose cyclase soluble guanylyl (sGC) stimulation has shown to have direct antifibrotic effects, improving myocardial remodeling in the absence of hemodynamic effects heart failure (HF) patients. The aim was study effect vericiguat, an oral stimulator sGC independently nitric oxide, on mitochondrial function and oxidative stress vitro under pro-inflammatory conditions, simulating HF conditions. Human Cardiac Fibroblasts (HCF) cellular line...
<p class="first" dir="auto" id="d1465465e159">Vericiguat, a soluble guanylate cyclase stimulator, provides additional benefits to standard treatment against heart failure (HF). It is known that decreased mitochondrial function and/or deficient process selectively remove damaged mitochondria (mitophagy) in cardiac cells are crucial HF progression. The aim was study vericiguat effect on mitophagy and an vitro under pro-inflammatory conditions, simulating conditions. Human Cardiac Myocytes...
<p class="first" dir="auto" id="d1573742e161">Vericiguat is a soluble guanylate cyclase (sGC) stimulator, which, in addition to vasodilatory optimal medical treatment for heart failure (HF), reduced incidence of cardiovascular death and HF hospitalization, suggesting additional effects vascular vasodilatation. The aim was study effect vericiguat on mitochondrial function oxidative stress an vitro under pro-inflammatory conditions, simulating conditions. Human cardiac microvascular...
(1) Background: Radical prostatectomy has a high incidence of erectile dysfunction (ED). The aim was to determine if the expression nitric oxide synthase-3/soluble guanylate cyclase/phosphodiesterase 5 axis could be detected in buccal mucosa and it differently expressed patients with without ED; (2) Methods: Erectile function from 38 subjects subjected evaluated using International Index Function-Erectile Function Domain before one year after surgery. Nitric synthase (NOS3), β1-subunit...
Early life stress (ELS) is associated with an increased risk for neuropsychiatric disorders, and both neuroinflammation mitochondrial dysfunction seem to be central mental health. Herein, using animal model of ELS, a single episode maternal deprivation (MD, 24 h on pnd 9) extensively documented elicit behavioural anomalies in male female Wistar rats, we investigated its consequences terms dynamics the prefrontal cortex (PFC) hippocampal formation (HCF). MD differentially affected brain...
In this paper, we experimented with a set of machine-learning classifiers for predicting the risk person being overweight or obese, taking into account his/her dietary habits and socioeconomic information. We investigate ten different algorithms combined four feature-selection strategies (two evolutionary methods, one feature selection from literature, no selection). tackle problem under binary classification approach selection. particular, use genetic algorithm to select variables...
Background and Objectives: Aspirin (ASA) is a commonly used antithrombotic drug that has been demonstrated to reduce venous thromboembolism. The aim was analyze if geriatric COVID-19 patients undergoing 100 mg/day treatment prior hospitalization differ in hospital outcome compared without previous ASA therapy. Materials Methods: An observational retrospective study carried out using an anonymized database including (March April 2020) admitted Madrid Hospitals Group. A group of were treated...
An inadequate platelet response to aspirin (ASA) has been identified in some patients under chronic ASA treatment. The aim of this study was analyze if ASA-sensitive and ASA-resistant platelets have differences their apoptotic capability. Clinically stable ischemic coronary who had taking (100 mg/d) for at least 9 months before inclusion were divided into (n = 11) 13) groups as defined by the PFA-100 test. Platelets from showed higher expression proapoptotic proteins Bak Bax than those...