A5015598934- Spinal Cord Injury Research
- Cerebral Palsy and Movement Disorders
- Neuroscience of respiration and sleep
- Nerve injury and regeneration
- Nerve Injury and Rehabilitation
- Balance, Gait, and Falls Prevention
- Respiratory Support and Mechanisms
- Muscle activation and electromyography studies
- Veterinary Orthopedics and Neurology
- Trauma Management and Diagnosis
- Stroke Rehabilitation and Recovery
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Proteoglycans and glycosaminoglycans research
- Motor Control and Adaptation
- Veterinary Pharmacology and Anesthesia
- Respiratory and Cough-Related Research
- Sleep and related disorders
- Pain Mechanisms and Treatments
- Family and Disability Support Research
- Infant Health and Development
- Spinal Dysraphism and Malformations
- Pharmacological Receptor Mechanisms and Effects
- Protease and Inhibitor Mechanisms
- Voice and Speech Disorders
University of Florida Health
2017-2023
University of Florida
2009-2022
Malcom Randall VA Medical Center
2007-2015
North Florida/South Georgia Veterans Health System
2011-2015
Florida College
2009
Rationale: Intermittent stimulation of the respiratory system with hypoxia causes persistent increases in motor output (i.e., long-term facilitation) animals spinal cord injury. This paradigm, therefore, has been touted as a potential rehabilitation strategy.Objectives: To determine whether acute (daily) exposure to intermittent can also evoke facilitation ventilation after chronic injury humans, and repeated daily enhances magnitude this response.Methods: Eight individuals incomplete (>1...
Abstract Chondroitinase ABC (Ch'ase ABC) is a bacterial lyase that degrades chondroitin sulfate (CS), dermatan sulfate, and hyaluronan glycosaminoglycans (GAGs). This enzyme has received significant attention as potential therapy for promoting central nervous system peripheral repair based on its degradation of CS GAGs. Determination the stability Ch'ase activity at temperatures equivalent to normal (37°C) elevated (39°C) body important optimizing clinical usage. We report here data obtained...
A number of studies have shown that chondroitinase ABC (Ch'ase ABC) digestion inhibitory chondroitin sulfate glycosaminoglycans significantly enhances axonal growth and recovery in rodents following spinal cord injury (SCI). Further, our group has improved SCI the larger cat model. The purpose current study was to determine whether intraspinal delivery Ch'ase ABC, T10 hemisections adult cats, adaptive movement features during a skilled locomotor task and/or promotes plasticity supraspinal...
A module is a functional unit of the nervous system that specifies functionally relevant patterns muscle activation. In adults, four to five modules account for activation during walking. Neurological injury alters modular control and associated with walking impairments. The effect neurological on in children unknown may differ from adults due their immature developing systems. We examined locomotor tasks incomplete spinal cord injuries (ISCIs) children. Five controls (8.6 ± 2.7 yr age)...
In the same way human body requires food, hydration, and oxygen, it also sleep. Even among healthy people, amount quality of sleep substantially influence health life because helps regulate physiological functioning. Given impact on participation, American Occupational Therapy Association reclassified from an activity daily living to occupational domain. Poor is a frequent medical complaint, especially populations with neurological impairment. therapy practitioners should consider routinely...
The authors previously reported on walking recovery in a nonambulatory child with chronic, severe, incomplete cervical spinal cord injury (SCI) after 76 sessions of locomotor training (LT). Although clinical measures did not predict his recovery, reciprocal patterned leg movements developed, affording independent reverse rolling walker. long-term functional limitations and secondary complications often associated pediatric-onset SCI necessitate continued follow-up children SCI. Therefore,...
The Neuromuscular Recovery Scale (NRS) was developed by researchers and clinicians to functionally classify people with spinal cord injury (SCI) measuring relevant motor tasks without compensation. Previous studies established strong interrater test-retest reliability validity of the scale.To determine responsiveness NRS, a version including newly added upper-extremity items, in an outpatient rehabilitation setting.Assessments using NRS 6 other instruments were conducted at enrollment...
Following a lateralized spinal cord injury (SCI) in humans, substantial walking recovery occurs; however, deficits persist adaptive features of locomotion critical for community ambulation, including obstacle negotiation. Normal negotiation is accomplished by an increase flexion during swing. If object unanticipated or supraspinal input absent, may involve the spinally organized stumbling corrective response. How these voluntary and reflex components are affected following partial SCI not...
Abstract The immature central nervous system is recognized as having substantial neuroplastic capacity. In this study, we explored the hypothesis that rehabilitation can exploit potential and elicit reciprocal walking in nonambulatory children with chronic, severe (i.e., lower extremity motor score < 10/50) spinal cord injuries (SCIs). Seven male subjects (3–12 years of age) who were at least 1‐year post‐SCI incapable discrete leg movements believed to be required for walking, enrolled...
Functional walking requires the ability to modify one's gait pattern environmental demands and task goals-gait adaptability. Following incomplete spinal cord injury (ISCI), rehabilitation such as locomotor training (Basic-LT) emphasizes intense, repetitive stepping practice. Rehabilitation approaches focusing on practice of adaptability tasks have not been established for individuals with ISCIs but may promote recovery higher level skills. The primary purpose this case series was describe...
Spinal injury (SCI) can significantly impair cough and the influence of SCI on spatiotemporal mechanisms responsible for this behavior are unknown. We hypothesized that spinal hemisection would produce deficits in components cough. Experiments were performed eight anesthetized spontaneously breathing cats. Esophageal pressure (Pes) rectus abdominis (RA) electromyograms (EMG) recorded before 4 weeks after left T10 hemisection. Cough was elicited by mechanical stimulation vocal folds...
Mounting evidence suggests daily hyperbaric oxygen treatment (HBOT) can enhance functional motor recovery after thoracic spinal cord injury (SCI), possibly through alterations in inflammatory signaling and reduced apoptosis at or near the lesion epicenter. The purpose of this initial study was to explore using HBOT as a rehabilitative tool cervical contusion injury. Rats were randomly divided into following groups: 1) naïve (no prior treatment), 2) sham operated (laminectomy only), 3)...
Abstract Importance: Visual function is critical to support occupational performance for persons with Parkinson’s disease (PwP), yet it can be adversely affected by the disease. Objective: To evaluate prevalence and general awareness of visual dysfunction identify association between in PwP. Design: Self-reported cross-sectional electronic survey. Participants: PwP, identified from a registered database at neurological institute, were invited complete survey through emails newsletters....
Efficient human walking requires the coordinated function of both upper and lower extremities. In healthy adults as speeds reach 0.8 m/s above, arms transition from an in-phase relationship to out-of-phase with each other. Further, arm swing synchronizes stride frequency contralateral leg. It is well documented that people Parkinson's disease (PD) show diminished during normal this may be one factor contributing increased falls in population. Yet, it unknown whether reduction affects...