A5052826861- Cancer, Hypoxia, and Metabolism
- Hippo pathway signaling and YAP/TAZ
- Metabolism, Diabetes, and Cancer
- Cancer-related Molecular Pathways
- Pancreatic function and diabetes
- Pancreatic and Hepatic Oncology Research
- Folate and B Vitamins Research
- Invertebrate Immune Response Mechanisms
- Cancer Cells and Metastasis
- Genomics and Chromatin Dynamics
- PARP inhibition in cancer therapy
- Glioma Diagnosis and Treatment
- DNA Repair Mechanisms
- Microtubule and mitosis dynamics
- Cancer, Lipids, and Metabolism
- Developmental Biology and Gene Regulation
- Mitochondrial Function and Pathology
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
University of Nebraska Medical Center
2022-2024
Nebraska Medical Center
2024
University of Würzburg
2023
Cisplatin- and gemcitabine-based chemotherapeutics represent a mainstay of cancer therapy for most solid tumors; however, resistance limits their curative potential. Here, we identify RNA polymerase II-associated factor 1 (PAF1) as common driver cisplatin gemcitabine in human cancers (ovarian, lung, pancreas). Mechanistically, cisplatin- gemcitabine-resistant cells show enhanced DNA repair, which is inhibited by PAF1 silencing. We demonstrate an increased interaction with RAD52 resistant...
The transcription factor SPT5 physically interacts with MYC oncoproteins and is essential for efficient transcriptional activation of targets in cultured cells. Here, we use
Abstract BACKGROUND Glioblastoma (GBM) is an aggressive malignancy, with a tumor doubling time of just 49.6 days. Despite maximal safe surgical resection, radiation, and temozolomide, median survival only 14.6 months. Homeobox gene, homeobox C10 (HOXC10), transcription factor the HOX10 family, pivotal in neuronal development, upregulated several cancers, including glioma, correlates poor survival. METHODS RNA sequencing analysis was done on our mouse glioma syngeneic cell lines. HOXC10...
Abstract Background: Reprogrammed cellular metabolism has been refocused on in the past decade, as many cancer cells rewire various metabolic pathways to facilitate their survival, unlimited cell growth, and division. RNA Polymerase II-Associated Factor 1 (PAF1)/Pancreatic Differentiation 2 (PD2) is a core subunit of human PAF1 Complex (PAF1C) that regulates polymerase II function during transcriptional elongation normal cells; however, its overexpression implicated promoting pancreatic...
Abstract The transcription factor SPT5 physically interacts with MYC oncoproteins and is essential for efficient transcriptional activation of targets in cultured cells. Here we use Drosophila to address the relevance this interaction a living organism. Spt5 displays moderate synergy Myc fast proliferating young imaginal disc During later development, Spt5-knockdown has no detectable consequences on its own, but strongly enhances eye defects caused by Myc-overexpression. Similarly, larval...