A5008900750- Pharmacogenetics and Drug Metabolism
- Cancer Treatment and Pharmacology
- Chronic Lymphocytic Leukemia Research
- Radiopharmaceutical Chemistry and Applications
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical studies and practices
- Drug Transport and Resistance Mechanisms
- Prostate Cancer Treatment and Research
- Ginkgo biloba and Cashew Applications
- Drug-Induced Hepatotoxicity and Protection
- Neutropenia and Cancer Infections
- Cancer therapeutics and mechanisms
- Statistical Methods in Clinical Trials
- Forensic Toxicology and Drug Analysis
- Multiple Myeloma Research and Treatments
- Epilepsy research and treatment
- Poisoning and overdose treatments
- PI3K/AKT/mTOR signaling in cancer
- Animal Ecology and Behavior Studies
- Acute Lymphoblastic Leukemia research
- Bone health and treatments
- Biosimilars and Bioanalytical Methods
- Innovative Microfluidic and Catalytic Techniques Innovation
- Pharmaceutical Practices and Patient Outcomes
The Netherlands Cancer Institute
2021-2025
Erasmus MC - Sophia Children’s Hospital
2021
The low incidence of vincristine-induced peripheral neuropathy (VIPN) in Kenyan children may result from vincristine exposure. We performed a pharmacokinetically (PK) guided dose-escalation feasibility study (NCT05844670). Vincristine PK exposure was assessed with previously developed nomogram. A 20% dose increase recommended for participants and no VIPN, hyperbilirubinemia or malnutrition. None the fifteen VIPN. Low seen only one participant: implemented without side-effects. Average high....
Abstract Purpose Recently, docetaxel treatment of metastatic prostate cancer patients shifted towards the hormone-sensitive stage disease. There are contradictive reports on differences in toxicity (mHSPC) and castration-resistant (mCRPC) patients. Possible might be attributed to different pharmacokinetics (PK) two patient populations. Methods Patients with mCRPC or mHSPC a standard indication for were included study. All had suppressed serum testosterone levels (≤ 0.5 ng/mL 1.73 nmol/L)....
Recent studies have reported ethnic differences in vincristine exposure and outcomes such as toxicity. This resulted the hypothesis of subtherapeutic dosing African children. To optimize individual treatment, a strategy to identify using therapeutic drug monitoring is essential. The aim current study was develop for children meet following criteria: (1) patients with low sufficient sensitivity (>70%), (2) determine limited sampling design 3 samples, (3) allow all samples be collected within...
There has been a significant increase in sodium azide intoxications since the 1980s. Intoxications caused by are becoming increasingly prevalent Netherlands as result of its promotion for purpose self-euthanasia. The mechanism toxicity is not completely understood but dose-dependent. presented case describes suicide young woman (26 years old) with history depression and attempts. decedent was found presence prescription medicine, including temazepam, domperidone combination omeprazole,...
Abstract The traditional design of food‐effect studies has a high patient burden for toxic drugs with long half‐lives (e.g., anticancer agents). Microtracers could be used to assess in patients without influencing their ongoing treatment. feasibility microtracer study during steady‐state the therapeutic drug was investigated an silico simulation alectinib as example relative half‐life. Microtracer pharmacokinetics were simulated based on previously published population pharmacokinetic model...
Abstract Microdosing is a strategy to obtain knowledge of human pharmacokinetics prior Phase I clinical trials. The most frequently used method extrapolate microdose (≤100 μg) therapeutic doses based on linear extrapolation from noncompartmental analysis (NCA) with two‐fold acceptance criterion between pharmacokinetic metrics the extrapolated and dose. major disadvantage NCA assumption metrics. In this study, we naïve pooled data (NPD) modeling approach pharmacokinetics. Gemcitabine...
Abstract Patients with prostate cancer (PCa) have a lower docetaxel exposure for both intravenous (1.8‐fold) and oral administration (2.4‐fold) than patients other solid cancers, which could influence efficacy toxicity. An altered metabolism by cytochrome P450 3A (CYP3A) due to castration status might explain the observed difference in pharmacokinetics. In this vivo phenotyping, pharmacokinetic study, CYP3A activity defined midazolam clearance (CL) was compared between PCa male tumors. All...