A5007795640- Burn Injury Management and Outcomes
- Adipose Tissue and Metabolism
- Wound Healing and Treatments
- Thermal Regulation in Medicine
- Climate Change and Health Impacts
- Exercise and Physiological Responses
- Cardiac Arrest and Resuscitation
- Thermoregulation and physiological responses
- Muscle metabolism and nutrition
- Injury Epidemiology and Prevention
- Mesenchymal stem cell research
- Adipokines, Inflammation, and Metabolic Diseases
- Trauma and Emergency Care Studies
- Disaster Response and Management
- Cerebral Palsy and Movement Disorders
- Dietary Effects on Health
- Pediatric Pain Management Techniques
- Appendicitis Diagnosis and Management
- Parallel Computing and Optimization Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Heme Oxygenase-1 and Carbon Monoxide
- Diet and metabolism studies
- Acute Myocardial Infarction Research
- Total Knee Arthroplasty Outcomes
- S100 Proteins and Annexins
The University of Texas Medical Branch at Galveston
2014-2022
United States Army Institute of Surgical Research
2017-2022
Galveston College
2020
The University of Texas Health Science Center at San Antonio
2019
The University of Texas Health Science Center at Houston
2019
University of Michigan
2019
New York Medical College
2019
Shriners Hospitals for Children - Galveston
2014-2018
Jerry L. Pettis Memorial VA Medical Center
2017
National Center for Advancing Translational Sciences
2015
Brown adipose tissue (BAT) has attracted scientific interest as an antidiabetic owing to its ability dissipate energy heat. Despite a plethora of data concerning the role BAT in glucose metabolism rodents, (if any) humans remains unclear. To investigate whether activation alters whole-body homeostasis and insulin sensitivity humans, we studied seven BAT-positive (BAT+) men five BAT-negative (BAT−) under thermoneutral conditions after prolonged (5–8 h) cold exposure (CE). The two groups were...
Elevated metabolic rate is a hallmark of the stress response to severe burn injury. This mediated in part by adrenergic and responsive changes ambient temperature. We hypothesize that uncoupling oxidative phosphorylation skeletal muscle mitochondria contributes increased survivors. Here, we determined mitochondrial function healthy severely burned adults. Indirect calorimetry was used estimate patients. Quadriceps biopsies were collected on two separate occasions (11 ± 5 21 8 days...
Acute alterations in skeletal muscle protein metabolism are a well-established event associated with the stress response to burns. Nevertheless, long-lasting effects of burn injury on turnover incompletely understood. This study was undertaken investigate fractional synthesis (FSR) and breakdown (FBR) rates pediatric patients (n = 42, >30% total body surface area burns) for up 1 year after injury. Skeletal kinetics were measured post-prandial state following bolus injections 13C6 15N...
Burn trauma results in prolonged hypermetabolism and skeletal muscle wasting. How contributes to wasting burn patients remains unknown. We hypothesized that oxidative stress, cytosolic protein degradation, mitochondrial stress as a result of contribute cachexia postburn. Patients ( n = 14) with burns covering >30% their total body surface area were studied. Controls 13) young healthy adults. found profoundly hypermetabolic at both the systemic levels, indicating increased oxygen...
Brown adipose tissue (BAT) plays an important role in thermoregulation rodents. Its temperature homeostasis people is less studied. To this end, we recruited 18 men [8 individuals with no/minimal BAT activity (BAT-) and 10 pronounced (BAT+)]. Each volunteer participated a 6 h, individualized, non-shivering cold exposure protocol. was quantified using positron emission tomography/computed tomography. Body core skin temperatures were measured telemetric pill wireless thermistors, respectively....
The long-term impact of burn trauma on skeletal muscle bioenergetics remains unknown. Here, the authors determined respiratory capacity and function mitochondria in healthy individuals victims for up to 2 years postinjury. Biopsies were collected from m. vastus lateralis 16 men (26 ± 4 years) 69 children (8 5 with burns encompassing ≥30% their total BSA. Seventy-nine biopsies cohorts at weeks (n = 18), 6 months 12 25), 24 18) postburn. Hypermetabolism was by difference predicted measured...
Introduction Severe burns result in prolonged hypermetabolism and skeletal muscle catabolism. Rehabilitative exercise training (RET) programs improved mass strength severely burned children. The combination of RET with β-blockade or testosterone analogs showed exercise-induced benefits on body composition function. However, the effect combined multiple drug therapy mass, strength, cardiorespiratory fitness, protein turnover are unknown. In this placebo-controlled randomized trial, we...
Volumetric muscle loss (VML) occurs after severe orthopedic trauma and results in of fibers function that can leave patients permanently disabled. Although animals models VML are useful to test possible therapeutic strategies, the pathophysiological characteristics remaining skeletal changes metabolism not thoroughly understood. Herein, alterations neuromuscular function, fiber morphology, myosin heavy chain expression, myofiber mitochondrial respiration were evaluated an adult Yorkshire...
Severe burn injury produces a plethora of metabolic abnormalities which contribute to the prolonged morbidity survivors. The authors have recently demonstrated trans-differentiation white adipose tissue (WAT) after trauma, toward more thermogenic phenotype. However, impact on subcutaneous WAT (sWAT) morphology in humans is unknown. Here, studied effect severe architecture sWAT. sWAT was collected from 11 severely burned children (11 ± 3 years; 55 16% total BSA burned) and 12 nonburned...
OBJECTIVES: To compare the diagnostic value of clinical sepsis criteria to novel protein biomarkers in burn patient. DESIGN: Prospective observational study. SETTING: American Burn Association verified Center ICU. PATIENTS: patients ( n = 24) and healthy volunteers 10). INTERVENTIONS: Enrolled were stratified based on whether or not they met a definition sepsis. Four separate for analyzed their sensitivity specificity, which compared panel biomarkers. The most significant further via area...
Since its establishment in 1943, the US Army Institute of Surgical Research (USAISR) has facilitated development innovative tech-
Severe burn injury results in systemic disruption of metabolic regulations and impaired cardiac function. Restoration hemodynamic homeostasis utilizing intravenous (IV) fluids is critical for acute care the victim. However, effects burns resuscitation on cardiomyocyte mitochondria are currently unknown. The purpose this study to determine mitochondrial function a swine model with subsequent using either crystalloids or colloids. Anesthetized Yorkshire (n = 23) sustained 40% total body...
ABSTRACT Sepsis is a common and often fatal consequence of severe burn injury, but its exact effects on whole body muscle metabolism in the patient unclear. To address this, 13 septic 11 nonseptic patients (age: 36.9 ± 13.0 years) with burns encompassing >30% their total surface area underwent protein kinetic studies under postabsorptive conditions using bolus injections ring- C 6 15 N phenylalanine isotopes. In parallel, whole-body lipid carbohydrate kinetics were assessed constant...
In recent combat operations, 5% to 15% of casualties sustained thermal injuries, which require resource-intensive therapies. During prolonged field care or when caring for patients in a multidomain battlefield, delayed transport will complicate the challenges that already exist burn population. A lack resources and/or vascular access future operating environment may benefit from alternative resuscitation strategies. The objectives current report are 1) briefly review actual and potential...
Background: Sepsis is the leading cause of mortality among burn patients that survive acute resuscitation. Clinical criteria have poor diagnostic value for burn-induced sepsis, making it difficult to diagnose. Protein biomarkers (e.g., procalcitonin) been examined with limited success. We aimed explore other related mitochondria (mitochondrial DNA [mtDNA]) and mitochondrial function peripheral blood mononuclear cells (PBMCs) sepsis diagnosis in patients. Methods: conducted a follow-up...
Purpose Early detection of occult abscesses is important in patients with persistent fever after colorectal surgery. In this study, the authors evaluated relative merits computed tomographic (CT) and Ga-67 scans intra-abdominal who had just undergone Materials Methods Thirty-four underwent surgery were enrolled study. CT obtained all patients. scintigraphy was performed 24 hours, later as needed, injection 111 MBq (3 mCi) citrate. Results Intra-abdominal diagnosed 16 34 (47%) For scans,...
Severe thermal injury induces metabolic and physiological stress, prompting a disruption in the hypothalamic-pituitary-adrenal axis. The objective of this study was to evaluate potential confounding effects Lactated Ringer's (LR) resuscitation on adrenal damage cortisol production following burn. Anesthetized swine were instrumented with jugular catheters sustained 40% TBSA burns from brass probes heated 100°C. Animals recovered consciousness received IV fluid LR at two different volumes: 15...
The acute systemic inflammatory response syndrome (SIRS) and multiorgan dysfunction (MOD) that occur in large burn injuries may be attributed, part, to immunosuppressive responses such as decreased lymphocytes. However, the mitochondrial bioenergetics of lymphocytes after severe injury are poorly understood. purpose this study was examine function following burns a swine model. Anesthetized Yorkshire (
Abstract Background Patients with severe burn injury (over 20% of the total body surface area) experience profound hypermetabolism which significantly prolongs wound healing. Adipose-derived stem cells (ASCs) have been proposed as an attractive solution for treating wounds, including potential autologous ASC expansion. While subcutaneous adipocytes display altered metabolic profile post-burn, it is not known if this case associated adipose tissue. Methods ASCs were isolated from discarded...
Journal Article 402 Enteral Resuscitation Shows Similar Efficacy to IV in a Porcine 40%TBSA Contact Model Get access D M Burmeister, PhD, PhD Institute of Surgical Research, San Antonio, TX; US Army TX Search for other works by this author on: Oxford Academic Google Scholar B Gómez, T Chao, L C Cancio, MD, MD A Dubick, Burn Care & Volume 39, Issue suppl_1, April 2018, Page S172, https://doi.org/10.1093/jbcr/iry006.324 Published: 09 2018