A5053416777- Epigenetics and DNA Methylation
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Fibroblast Growth Factor Research
- Kruppel-like factors research
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Cancer-related gene regulation
- HVDC Systems and Fault Protection
- Cellular transport and secretion
- Protein Tyrosine Phosphatases
- Immunotherapy and Immune Responses
- Peptidase Inhibition and Analysis
- PI3K/AKT/mTOR signaling in cancer
- Protease and Inhibitor Mechanisms
- CAR-T cell therapy research
University of Bern
2024
University of Stuttgart
2017-2020
Paracrine activation of cells contained in the tumor microenvironment promotes progression and metastasis. In breast cancer, malignant recruit educate macrophages into a M2 tumor-promoting phenotype that supports metastatic spread cancer cells. Here, we show miR-149 functions as metastasis-suppressing microRNA by limiting colony-stimulating factor-1 (CSF1)-dependent recruitment polarization macrophages. lymph node-positive, triple-negative (TNBC) tissues, low expression correlated with...
The PI3K-Akt pathway is one of the most commonly dysregulated cancer-associated signaling pathways. Here we report an oncogenic function for miR-181 family in luminal breast cancer cells that involves Akt hyperactivation. We show miR-181a and miR-181d posttranscriptionally suppress expression PHLPP2 INPP4B phosphatases, resulting elevated growth factor-induced phosphorylation. Ectopic promoted S-phase entry cell proliferation, which was reversed by pharmacological inhibition. Importantly,...
N6-methylated adenine (m6A) is the most frequent posttranscriptional modification in eukaryotic mRNA. Turnover of RNA generates AMP (N6-mAMP), which has an unclear metabolic fate. We show that Arabidopsis thaliana and human cells require N6-mAMP deaminase (ADAL, renamed MAPDA) to catabolize inosine monophosphate vivo by hydrolytically removing aminomethyl group. A phylogenetic, structural, biochemical analysis revealed many fungi partially or fully lack MAPDA, coincides with a minor role...
Matrix metalloproteinases (MMPs) degrade several ECM components and are crucial modulators of cell invasion tissue organization. Although much has been reported about their function in remodeling health disease, trafficking across the Golgi apparatus remains poorly understood. Here we report that cis-Golgi protein nucleobindin-1 (NUCB1) is critical for MMP2 MT1-MMP along apparatus. This process Ca2+-dependent required invasive MDA-MB-231 migration as well gelatin degradation primary human...
Despite the recent progress, current treatment modalities are not able to eradicate cancer. We show that Microbeam Radiotherapy (MRT), an innovative type of Spatially Fractionated Radiotherapy, can control murine melanoma by activating host's own immune system. The beneficial effects very pronounced in comparison uniform radiotherapy traditionally employed clinic. Our results MRT increased antigen presentation, Cytotoxic T Lymphocytes (CTLs) which essential MRT's efficacy melanoma. Depletion...
<p>Predicted miR-149 target genes in TNBC.</p>
<p>Supplementary Material and Methods Supplementary Figure Legends</p>
<p>miR-149 regulation of cell motility by paracrine signaling</p>
<p>Characterization of MDA-MB-231 cells stably expressing miR-149</p>
<p>Supplementary Material and Methods Supplementary Figure Legends</p>
<p>miR-149 regulation of cell motility by paracrine signaling</p>
<p>Predicted miR-149 target genes in TNBC.</p>
<p>Characterization of MDA-MB-231 cells stably expressing miR-149</p>
<div>Abstract<p>Paracrine activation of cells contained in the tumor microenvironment promotes progression and metastasis. In breast cancer, malignant recruit educate macrophages into a M2 tumor–promoting phenotype that supports metastatic spread cancer cells. Here, we show miR-149 functions as metastasis-suppressing microRNA by limiting colony-stimulating factor-1 (CSF1)–dependent recruitment polarization macrophages. lymph node–positive, triple-negative (TNBC) tissues, low...
<div>Abstract<p>Paracrine activation of cells contained in the tumor microenvironment promotes progression and metastasis. In breast cancer, malignant recruit educate macrophages into a M2 tumor–promoting phenotype that supports metastatic spread cancer cells. Here, we show miR-149 functions as metastasis-suppressing microRNA by limiting colony-stimulating factor-1 (CSF1)–dependent recruitment polarization macrophages. lymph node–positive, triple-negative (TNBC) tissues, low...