A5076391018- Epigenetics and DNA Methylation
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Fibroblast Growth Factor Research
- Influenza Virus Research Studies
- RNA Interference and Gene Delivery
- Cell death mechanisms and regulation
- COVID-19 epidemiological studies
- COVID-19 and Mental Health
- Geriatric Care and Nursing Homes
- Kruppel-like factors research
- Congenital heart defects research
- Phagocytosis and Immune Regulation
- RNA modifications and cancer
- Telomeres, Telomerase, and Senescence
- Cannabis and Cannabinoid Research
- Hematopoietic Stem Cell Transplantation
- Diabetes Management and Research
- Infection Control and Ventilation
- Sepsis Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Parasites and Host Interactions
University Medical Center Freiburg
2017-2025
Karolinska Institutet
2010-2023
University of Freiburg
2017-2020
University of Stuttgart
2020
Karolinska University Hospital
2010-2012
Uppsala University
2010-2012
Uppsala University Hospital
2010
Swedish Research Council
2010
Memorial Foundation
2010
Paracrine activation of cells contained in the tumor microenvironment promotes progression and metastasis. In breast cancer, malignant recruit educate macrophages into a M2 tumor-promoting phenotype that supports metastatic spread cancer cells. Here, we show miR-149 functions as metastasis-suppressing microRNA by limiting colony-stimulating factor-1 (CSF1)-dependent recruitment polarization macrophages. lymph node-positive, triple-negative (TNBC) tissues, low expression correlated with...
The GATA2 transcription factor is a pivotal regulator of hematopoiesis. Disruptions in the gene drive severe hematologic abnormalities and are associated with an increased risk myelodysplastic syndromes acute myeloid leukemia; however, mechanisms underlying pathophysiology deficiency remain still unclear. We developed two different mouse models that based on serial limiting donor cell transplantation (aged) haploinsufficient cells mirror symptoms deficiency. Similar to what has been observed...
<title>Abstract</title> The advent of high-throughput sequencing has led to an exponential increase in genomic data, highlighting the need for efficient and accurate models analyze interpret this information. Here, we introduce a novel, exomic foundational model that leverages combination human reference genome multispecies data improve variant detection interpretation. Our utilizes short- range transformer architecture is trained on large dataset sequences derived from Tapestry study....
The COVID-19 pandemic is growing and spread in the Swedish elderly care system during April 2020. increasing number of employees on sick-leave due to created severe logistic problems. Some homes therefore started screen their personnel secure safety avoid unnecessary quarantine potentially immune employees. Secondary data from a screening with rapid test for detection SARS-CoV-2-specific IgM IgG 1,005 22 Stockholm, Sweden, were analyzed. Seropositive found 21 out homes. In total, 23%...
Brain death impairs organ function and outcome after transplantation. There is a need for brain model to allow studies of viability preservation. For neurointensive care research, it also interest have relevant intracranial dynamics evaluation cerebral monitoring devices. Therefore, the objective was develop standardized clinically model.Six pigs both sexes (10-12 wks old; mean weight, 24.5±1.4 kg) were included. Mean arterial blood pressure, heart rate, compliance, perfusion tissue...
BH3-mimetics inhibiting anti-apoptotic BCL-2 proteins represent a novel and promising class of antitumor drugs. While the inhibitor venetoclax is already FDA-approved, BCL-XL MCL-1 inhibitors are currently in early clinical trials. To predict side effects therapeutic inhibition on human hematopoietic system, we used RNAi small molecule S63845 cord blood-derived CD34+ cells. Both approaches resulted almost complete depletion stem progenitor As consequence, maturation into different lineages...
During hematopoietic stem cell transplantation, a substantial number of donor cells are lost because apoptotic death. Transplantation-associated apoptosis is mediated mainly by the proapoptotic BCL-2 family proteins BIM and BMF, their function conserved between mouse human progenitor cells. Permanent inhibition in caused loss these BH3-only improves transplantation outcome, but recipients might be exposed to increased risk lymphomagenesis or autoimmunity. Here, we address whether transient...
Susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is highly variable and could be mediated by a cross-protective pre-immunity. We identified 14 cross-reactive peptides between SARS-CoV-2 influenza A H1N1, H3N2, human herpesvirus (HHV)-6A/B with potential relevance. The H1N1 peptide NGVEGF was identical in the most critical receptor binding motif spike protein that interacts angiotensin converting enzyme receptor. About 62%–73% of COVID-19-negative...
Proper revascularization after transplantation is assumed to be crucial for appropriate islet graft function. We developed a novel noninvasive imaging method, based on adenoviral transduction of islets with hypoxia responsive reporter gene, continuous in vivo monitoring grafts mouse model. In addition, morphological data were obtained from deceased patient previously subject intraportal transplantation. detected only transient minority the animals transplanted. Importantly, clear response...
Abstract Background Susceptibility to SARS-CoV-2 infections is highly variable, ranging from asymptomatic and mild in most, deadly outcome few. This individual difference susceptibility could be mediated by a cross protective pre-immunity, but the nature of this pre-immunity has remained elusive. Methods Antibody epitope sequence similarities cross-reactive T cell peptides were searched for between other pathogens. We established an ELISA test, Luminex Multiplex bead array assay test...
Abstract Background Anticoagulants (AC) were introduced in March 2020 as standard of care nursing home (NH) residents affected with COVID‐19 the Stockholm region, Sweden. ACs are proven to reduce risk complications and mortality from among patients other ages settings, but there is limited scientific evidence underpinning this practice NH setting. Methods This matched cohort study included 182 Region diagnosed March–May 2020. The main exposure was any AC treatment. Exposed ( n = 91), 49%...
The GATA2 transcription factor is a pivotal regulator of hematopoiesis. Disruptions in the gene drive severe hematologic abnormalities and are associated with an increased risk myelodysplastic syndromes acute myeloid leukemia; however, mechanisms underlying pathophysiology deficiency remain still unclear. We developed two different mouse models that based on serial limiting donor cell transplantation (aged) haploinsufficient cells mirror symptoms deficiency. Similar to what has been observed...
<div>Abstract<p>Paracrine activation of cells contained in the tumor microenvironment promotes progression and metastasis. In breast cancer, malignant recruit educate macrophages into a M2 tumor–promoting phenotype that supports metastatic spread cancer cells. Here, we show miR-149 functions as metastasis-suppressing microRNA by limiting colony-stimulating factor-1 (CSF1)–dependent recruitment polarization macrophages. lymph node–positive, triple-negative (TNBC) tissues, low...
<div>Abstract<p>Paracrine activation of cells contained in the tumor microenvironment promotes progression and metastasis. In breast cancer, malignant recruit educate macrophages into a M2 tumor–promoting phenotype that supports metastatic spread cancer cells. Here, we show miR-149 functions as metastasis-suppressing microRNA by limiting colony-stimulating factor-1 (CSF1)–dependent recruitment polarization macrophages. lymph node–positive, triple-negative (TNBC) tissues, low...
<p>Predicted miR-149 target genes in TNBC.</p>
<p>Supplementary Material and Methods Supplementary Figure Legends</p>
<p>miR-149 regulation of cell motility by paracrine signaling</p>
<p>Characterization of MDA-MB-231 cells stably expressing miR-149</p>
<p>Supplementary Material and Methods Supplementary Figure Legends</p>
<p>miR-149 regulation of cell motility by paracrine signaling</p>
<p>Predicted miR-149 target genes in TNBC.</p>