A5103053757- Dental Radiography and Imaging
- Periodontal Regeneration and Treatments
- Dental Implant Techniques and Outcomes
- Pancreatic function and diabetes
- Endodontics and Root Canal Treatments
- Oral microbiology and periodontitis research
- Oral and gingival health research
- Organ Transplantation Techniques and Outcomes
- Diabetes and associated disorders
- Diabetes Management and Research
- Organic Chemistry Cycloaddition Reactions
- Genetics and Neurodevelopmental Disorders
- Diet, Metabolism, and Disease
- Pancreatitis Pathology and Treatment
- Dental Trauma and Treatments
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Nuclear Receptors and Signaling
- Magnesium in Health and Disease
- Renal function and acid-base balance
- Retinoids in leukemia and cellular processes
- Liver Disease and Transplantation
- Cannabis and Cannabinoid Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Orthodontics and Dentofacial Orthopedics
Karolinska Institutet
1995-2021
Stockholm County Council
1995-2021
Eastmaninstitutet
2019
Gävle Hospital
2011
Uppsala University
1993-2010
Karolinska University Hospital
1995-2010
Uppsala University Hospital
2010
Swedish Research Council
2010
Memorial Foundation
2010
Stockholm South General Hospital
1997
In addition to its role as a 9-cis retinoic acid receptor, RXR has an important in the regulation of multiple hormonal pathways through heterodimerization with nuclear receptors. Here, we show that two orphan receptors, NGFI-B and NURR1, which have been shown previously interact DNA monomers, also can heterodimerize RXR. These heterodimers bind selectively class response elements composed direct repeats spaced by 5 nucleotides. this respect they are similar formed between receptor for...
Long-term follow-up of oral implant therapy seldom report all biological and technical complications. The objective this study was to evaluate the long-term (9-15 years) outcome after dental therapy, assess survival complication rates. In addition, identify risk indicators these complications at patient levels. Patients (n = 376) treated with implants 1095) between 1999 2005 a specialist clinic in Stockholm, Sweden, were included. Longitudinal data collected retrospectively from digital...
The purpose of the present study was to compare bone height determinations implant sites by different radiographic techniques. Available measured in regions posterior mental foramen on panoramic radiographs, and tomographs where faciolingual dimensions at least 5mm. one heights were recorded 401 edentulous denate 100 patients. overall mean ±SD) 11.25±3.29mm radiographs 8.81±3.38mm tomographs. correlation between two techniques ranged from 0.36 0.91 if material stratified according factors...
Abstract Aims/Background: The aims of the present study were to evaluate (1) success rate unilateral maxillary fixed dental prosthesis (FDPs) on implants in patients at a periodontal clinic referred for treatment, (2) prevalence varying mechanical and biological complications (3) effects potential risk factors rate. Material methods: Fifty consecutive invited participate follow‐up. had received FDPs between November 2000 December 2003 after treatment achieve optimal peridontal health, been...
Brain death impairs organ function and outcome after transplantation. There is a need for brain model to allow studies of viability preservation. For neurointensive care research, it also interest have relevant intracranial dynamics evaluation cerebral monitoring devices. Therefore, the objective was develop standardized clinically model.Six pigs both sexes (10-12 wks old; mean weight, 24.5±1.4 kg) were included. Mean arterial blood pressure, heart rate, compliance, perfusion tissue...
Objective: The aim of this questionnaire study was to investigate patient satisfaction 8–14 years after dental implant therapy and complications influencing the degree satisfaction.Materials methods: A sent by post 587 patients at a specialist clinic periodontology. consisted 19 statements or questions such as with implants knowledge complications. In nine questions, respondents were asked grade extent their agreement statement selecting from fixed answers. Three designed be answered using...
Abstract. Periapical pathology indicating endodontic infection, when present in periodontitis‐affected teeth, has recently been shown to be correlated marginal periodontal breakdown. This associated with patency of dentinal tubules the tooth cervix, an area normally devoid cementum following therapy. These studies are, however hampered by that only circumstantial evidence such as presence periapical destruction have applied criteria infection. The aim investigation was assess effects...
Abstract Periapical pathology indicating endodontic infection, when present in marginal periodontitis‐affected teeth, has recently been shown to be an aggravating factor progression of destruction. This associated with patency dentinal tubules the tooth cervix, area normally devoid cementum following periodontal therapy. These studies are, however hampered by that only circumstantial evidence such as presence periapical destruction have applied criteria infection. The purpose investigation...
In a recent study it was found that following non-surgical treatment, probing depth (PD) reduction in proximal sites is significantly less the presence of vertical destruction adjacent site neighboring tooth. The present investigation undertaken to whether furcation involvement also influences periodontal conditions tooth.The conducted as retrospective on consecutive referral population based full-mouth oral radiographic examinations and PD plaque score registrations. statistical analyses...
Whole pancreatic blood flow (PBF) and islet (IBF) were measured in anesthetized Sprague-Dawley rats aged 5, 20, 52, or 104 wk. PBF decreased progressively with age, from approximately 0.55 mL x min-1 g pancreas-1 5- 20-wk-old to 0.30 min- 52- 104-wk-old rats. In animals 5 wk, the IBF was 25 µL but increased about 60 µL: (p<0.001) 20–104 wks. When expressed as a fraction of PBF, different pattern observed. 5-wk-old only 5% flowed through islets, whereas 20 wk had fractional 10%. A...
Syngeneic mouse islets were transplanted under the renal capsule of athymic nude (nu/nu) C57BL/6 mice. Likewise, neonatal rat or fetal porcine islet-like cell clusters (ICC) into The animals killed at various times after implantation and graft-bearing kidney was removed. transplant processed for microscopic examination with indirect immunofluorescence neuropeptides tyrosine hydroxylase, acetylcholine esterase staining to visualize nerve fibers in graft. In all grafts, reinnervation both...
Islet blood flow stimulation induced by alloxan leads to an increased perfusion in all islets, whereas glucose induces a increase only subgroup of islets. The aim the present study was investigate if islet associated with enhanced total number perfused or whether islets their flow. For this purpose, whole pancreatic and measured microsphere technique (4.5×105 microspheres/kg body wt) anesthetized Sprague-Dawley rats. Blood measurements were made 3 min after iv injection 1 mL saline, (75...
Abstract. The functional responses of the pancreatic B-cells after cytotoxic damage are still largely unknown. Using in vitro models to clarify this issue, we have recently observed a preferential reduction glucose-stimulated insulin production and release mouse islets maintained culture exposure streptozotocin. In order evaluate relevance these findings vivo, two sets experiments were performed. First, exposed 2.2 mmol/l streptozotocin or vehicle alone, cultured for 6 days, finally grafted...
The aim was to assess the degree of radiographic peri-implant bone loss over a follow-up period up 15 years. In addition, another identify risk indicators for and moderate-severe peri-implantitis at patient- implant level.This is cross-sectional clinical radiological study 147 patients with total 425 implants in combination data collected retrospectively baseline variables. To calculate (primary outcome variable), level measurements from were compared final measurement. Multilevel analyses...
Portal hypertension (PH) is associated with a hyperdynamic splanchnic circulation, partially mediated by nitric oxide-dependent mechanisms. The aim of the present study was to evaluate influence PH and oxide on pancreatic islet blood flow. induced calibrated stenosis portal vein in male Sprague-Dawley rats. Control rats were sham-operated. Ten days later pancreatic, duodenal, colonic, arterial hepatic flows measured micro-spheres. All flow values markedly increased fraction whole diverted...
Corticotropin-releasing factor (CRF) has previously been shown to selectively dilate the mesenteric vascular bed, without affecting other beds. Pancreatic blood flow and islet were therefore measured separately with a microsphere technique in two regions of rat pancreas perfused by superior artery (SMA) or celiac (CA) respectively. Intravenous infusion CRF (0.25 μg/kg b.w./min) caused an increase both whole pancreatic region SMA. The fraction diverted through islets this part was, however,...
Kasper Aanaes Shawn Aaron Janice Abbott Frank Accurso Moira Aitken Michael Anstead Robert Aris Deborah Baines Jennifer Bartlett Tara Barto Ivan Bastian Jeffrey Beekman Scott Bell William Bennett Ariel Benson Paul Beringer Berlinski Jocelyn Bescond Julie Biller Diana Bilton Blackman Hannah Blau Cristina Bombieri Richard Boucher Frederic Bouillaud Stephen Bourke Cynthia Brady Michelle Brotherwood Emanuela Bruscia Mandy Bryon Lucy Burr Chris Burtin Andre Cantin Rafael Canton Giussepe Castaldo...