A5087998951- Neuropeptides and Animal Physiology
- Pain Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet and metabolism studies
- T-cell and B-cell Immunology
- Adipose Tissue and Metabolism
- Pharmacological Receptor Mechanisms and Effects
- Tryptophan and brain disorders
- Barrier Structure and Function Studies
- Invertebrate Immune Response Mechanisms
- Genetic and phenotypic traits in livestock
- Genetic diversity and population structure
- Olfactory and Sensory Function Studies
- Immune Cell Function and Interaction
- Animal Genetics and Reproduction
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Sepsis Diagnosis and Treatment
- Immune cells in cancer
- Gastrointestinal motility and disorders
- Anesthesia and Neurotoxicity Research
Medical University of Warsaw
2016-2025
Polish Academy of Sciences
2016-2025
Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences
2021-2024
University Medical Center Hamburg-Eppendorf
2021
Universität Hamburg
2021
Institute of Plant Genetics, Polish Academy of Sciences
2003-2018
Mossakowski Medical Research Institute, Polish Academy of Sciences
2013-2015
Central Forensic Laboratory of the Police
2008
Abstract The mechanism underlying the association between elevated red cell distribution width (RDW) and poor prognosis in variety of diseases is unknown although many researchers consider RDW a marker inflammation. We hypothesized that directly affects intravascular hemodynamics, interactions circulating cells vessel wall, inducing local changes predisposing to atherothrombosis. applied different human animal models verify our hypothesis. Carotid plaques harvested from patients with high...
The outstanding sensitivity of the canine olfactory system has been acknowledged by using sniffer dogs in military and civilian service for detection a variety odors. It is hypothesized that ability determined polymorphisms receptor (OR) genes. We investigated 5 OR genes polymorphic sites which might affect different fields specific substance detection. All DNA sequences proved to have allelic variants, majority lead protein sequence alteration. Homozygous individuals at 2 gene loci...
Understanding the evolution of interleukins and interleukin receptors is essential to control function CD4+ T cells in various pathologies. Numerous aspects cells’ presence are controlled by including differentiation, proliferation, plasticity. have emerged during divergence jawed vertebrates. However, little known about their origin. We traced from Placozoa primates. performed phylogenetic analysis, ancestral reconstruction, HH search, positive selection analysis. Our results indicated that...
Background: Cannabis sativa L. and its products are becoming popular for the treatment of inflammatory diseases. One main phytocannabinoids contained in cannabis is cannabidiol (CBD), which a component numerous cosmetic preparations used to treat skin diseases such as atopic dermatitis (AD) psoriasis. However, current data regarding efficacy safety CBD dermatological indications limited. Therefore, aim present study was evaluate anti-inflammatory effect high-CBD extract (eCBD) model AD....
Infiltration of the endothelial layer blood-brain barrier by leukocytes plays a critical role in health and disease. When passing through during diapedesis process lymphocytes can either follow paracellular route or transcellular one. There is debate whether these two processes constitute one mechanism, they form evolutionary distinct migration pathways. We used artificial intelligence, phylogenetic analysis, HH search, ancestor sequence reconstruction to investigate further this intriguing...
A genetic analysis was performed on Polish ostriches from the 3 principal ostrich breeds: red-, blue-, and black-necks. The based 2 molecular methods: DNA fingerprinting microsatellites. patterns were obtained using restriction enzyme Hin fI Jeffrey's 33.15 probe. second method consisted of a PCR procedure, for which 5 VIAS-OS primers specific to used. products separated polyacrylamide gel ALFexpress (Authomated Laser Fluorescent Sequencer). study aimed at assessing variability within among...
Opioid peptides and their G protein-coupled receptors are important regulators within the cardiovascular system, implicated in modulation of both heart vascular functions. It is known that naloxone—an opioid antagonist—may exert a hypertensive effect. Recent experimental clinical evidence supports role inflammatory mechanisms hypertension. Since opioids may play regulation blood pressure immune response, we studied these two processes our model. We aimed to evaluate effect selective...
Susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is highly variable and could be mediated by a cross-protective pre-immunity. We identified 14 cross-reactive peptides between SARS-CoV-2 influenza A H1N1, H3N2, human herpesvirus (HHV)-6A/B with potential relevance. The H1N1 peptide NGVEGF was identical in the most critical receptor binding motif spike protein that interacts angiotensin converting enzyme receptor. About 62%–73% of COVID-19-negative...
The role of the opioid system in mediating effects alcoholism and stress depression is far from clear. We studied, therefore, chronic mild (CMS) alcohol drinking on depression-like behavior nociception lines mice selected for high (HA) or low (LA) swim stress-induced analgesia. Compared to LA mice, HA animals display up-regulation receptor function tail suspension test (TST). report now that reverses depressive pronociceptive effect CMS mice. In contrast, does not affect TST are susceptible...
Background and Purpose The opioid system plays a crucial role in several physiological processes the CNS periphery. It has also been shown that selective receptor agonists exert potent inhibitory action on pruritus pain. In this study we examined whether two analogues of S alvinorin A, PR ‐37 ‐38, exhibit antipruritic properties mice. Experimental Approach To examine antiscratch effect ‐38 used mouse model compound 48/80‐induced pruritus. order to elucidate mechanism tested compounds,...
Colorectal cancer is the source of one most common cancer-related deaths worldwide, where main cause patient mortality remains metastasis. The aim this study was to determine role CCL7 (chemokine (C-C motif) ligand 7) in tumor progression and finding whether it could predict survival colorectal patients. Initially, our focused on crosstalk between mesenchymal stem cells (MSCs) CT26 colon carcinoma resulted identifying as a chemokine upregulated cocultured with MSCs, compared monoculture...
Both chronic stress conditions and hyperergic reaction to environmental are known enhance cancer susceptibility. We described two mouse lines that displayed high (HA) low (LA) swim stress-induced analgesia (SSIA) investigate the relationship between inherited differences in sensitivity proneness an increased growth rate of subcutaneously inoculated melanoma. These display several genetic physiological differences, among which distinct mutagens susceptibility especially noticeable. High...