A5004693891- Nuclear Engineering Thermal-Hydraulics
- Risk and Safety Analysis
- Laser Material Processing Techniques
- Advanced Surface Polishing Techniques
- Combustion and Detonation Processes
- Nuclear Materials and Properties
- Laser-induced spectroscopy and plasma
- Heat Transfer and Boiling Studies
- Nuclear reactor physics and engineering
- Probabilistic and Robust Engineering Design
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Ocular and Laser Science Research
- Metal and Thin Film Mechanics
- Diamond and Carbon-based Materials Research
- Lung Cancer Research Studies
- Esophageal Cancer Research and Treatment
- Anaerobic Digestion and Biogas Production
- Fluid Dynamics Simulations and Interactions
- Industrial Technology and Control Systems
- Advanced Algorithms and Applications
- Catalytic Processes in Materials Science
- Catalysis and Hydrodesulfurization Studies
- Gastric Cancer Management and Outcomes
- Advanced Decision-Making Techniques
Wuxi People's Hospital
2025
Nanjing Medical University
2025
North China Electric Power University
2015-2024
Centre Procédés, Energies Renouvelables et Systèmes Energétiques
2023-2024
Université Paris Sciences et Lettres
2024
China Academy of Engineering Physics
2018-2024
BeiGene (China)
2024
Ministry of Water Resources of the People's Republic of China
2019-2024
Xinjiang University
2024
China Institute of Water Resources and Hydropower Research
2024
The residual crack defects on the surface of potassium dihydrogen phosphate (KDP) crystals are bottleneck that limits improvement laser damage resistance in application high-power devices. multiple stress waves introduced by these lateral cracks under irradiation main inducement for extension and reduction resistance. However, coupling complicates their propagation crystal, interaction mechanism between each wave has not been quantitatively characterized. Herein, a dynamic model is...
Hereditary tyrosinemia type I (HTI) is a metabolic genetic disorder caused by mutation of fumarylacetoacetate hydrolase (FAH). Because the accumulation toxic metabolites, HTI causes severe liver cirrhosis, failure, and even hepatocellular carcinoma. an ideal model for gene therapy, several strategies have been shown to ameliorate symptoms in animal models. Although CRISPR/Cas9-mediated genome editing able correct Fah mouse models, WT Cas9 induces numerous undesired mutations that raised...
Point defects with different species are concentrated on most mechanically machined fused silica optical surfaces surface defects, which would sharply decrease the laser damage resistance under intense irradiation. Various point have distinct roles in affecting resistance. Especially, proportions of various not been identified, posing challenge relating intrinsic quantitative relationship among defects. To fully reveal comprehensive effect it is necessary to systematically explore origins,...
Abstract Proline-rich 15 (PRR15) is a protein primarily known for its role in placental development. This study investigates the expression, functional significance, and underlying mechanisms of PRR15 non-small cell lung cancer (NSCLC). Our findings demonstrate significantly elevated expression NSCLC tissues compared to normal parenchyma, with higher correlating adverse clinical outcomes. Single-cell RNA sequencing confirmed overexpression within malignant tumor population. was from locally...
When potassium dihydrogen phosphate (KDP) crystals are exposed to high-energy laser irradiation, the pre-existing surface defects may act as damage precursors and will reduce lifespan of crystal components. Although it has been found that different kinds exhibit distinct characteristics, influence on laser-induced performance KDP is not yet clear. In this paper, have characterized by multiple measuring methods classified into five categories according their structure features. Laser-induced...
Ultraintense optical vortices carrying orbital angular momentum have attracted much attention in strong-field laser physics due to their spiral phase and hollow intensity. This Letter introduces a fully continuous plate (FC-SPP) that enables the generation of an ultraintense Laguerre-Gaussian beam. An optimization design method based on spatial filter technique chirp-z transform is proposed match polishing processing tightly focusing performance. To enable its use high-power systems,...
This study delves into the intricate dynamics of laser-induced damage in fused silica using a time-resolved pump-probe (TRPP) shadowgraph. Three typical ultra-fast processes, plasma evolution, shockwave propagation and material fracture splashing, were quantitatively investigated. The results indicate that diameter is proportional to pulse laser energy increases linearly during duration with an expansion rate approximately 6 km/s. maximum velocity on air side 9 km/s, occurring at end...
To evaluate the importance of specific driver mutations to development and outcome lung squamous cell cancer (SQCC) in never-smokers, we assessed clinicopathological characteristics outcomes 597 patients who underwent complete resection SQCCs. In total, 88 (14.7%) never-smokers 509 (85.3%) ever-smokers were compared. The included more females (42.05% vs. 1.57%, P < 0.001) often had a personal history malignant disease (9.09% 2.36%, = 0.003). tumors poorly differentiated (70.45% 53.24%,...
Background: Chinese Herb Medicine Formulas (CHMF) was reported to improve the quality of life (QoL) in advanced NSCLC patients. The present study designed investigate whether maintenance chemotherapy plus CHMF patients would QoL and progression-free survival (PFS). Methods: Seventy-one (71) were enrolled from 8 medical centers China, randomly assigned a group (n =35) or placebo (n=36). outcome measures included PFS, Karnofsky performance status (KPS) scores, (assessed with lung cancer...
Abstract BACKGROUND Owing to the growing consumption of oil and negative environmental impacts, production p ‐xylene (PX) from renewable biomass has gained significant attention recently. However, major challenge for PX or furans is how improve yield selectivity PX, along with reducing coke. RESULTS The para in catalytic conversion was greatly enhanced owing deactivation external surface adjustment pore entrance. Co‐catalytic methanol significantly by Diels–Alder reactions between olefins...
Objective Identify the molecular mechanism of inflammatory stimuli induced pancreatic cancer progression. Methods RNA-seq, microarray assay and bioinformatics analyses were used to identify differentially expressed genes. Immunohistochemical staining was performed evaluate CD68, CD163, β-catenin, CD103, CCL3 markers. Quantitative real-time polymerase chain reaction (qRT-PCR), luciferase reporter assay, apoptosis wound healing immunofluorescence study relationship WNT/β-catenin pathway....
Abstract Background The toxicity and side effects caused by adjuvant chemotherapy (ACT) after radical surgery for lung adenocarcinoma (LAC) lead to early termination frequently. This study was conducted provide an objective basis the effect of Chinese herbal medicine formulas (CHMFs) combined with in reducing enhancing efficacy ACT. Method From February 17th, 2012 March 20th, 2015, 233 patients from 7 hospitals diagnosed LAC IB~IIIA stage were randomly assigned into ACT + CHMF group (116...