A5072020126- Chronic Lymphocytic Leukemia Research
- Wound Healing and Treatments
- Mesenchymal stem cell research
- Acute Lymphoblastic Leukemia research
- Osteoarthritis Treatment and Mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Agricultural and Food Sciences
- Molecular Biology Techniques and Applications
- Insect Pest Control Strategies
- Pomegranate: compositions and health benefits
- Lymphoma Diagnosis and Treatment
- Periodontal Regeneration and Treatments
- Diptera species taxonomy and behavior
- Genomic variations and chromosomal abnormalities
- Forensic Entomology and Diptera Studies
- Genetics, Bioinformatics, and Biomedical Research
- Genomics and Phylogenetic Studies
- Graphene and Nanomaterials Applications
- Cardiac Imaging and Diagnostics
- Folate and B Vitamins Research
- Bioactive Natural Diterpenoids Research
- Rural Development and Agriculture
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Trypanosoma species research and implications
Universidade Federal do Espírito Santo
2015-2023
Departamento de Ciência e Tecnologia
2017
International Centre for Genetic Engineering and Biotechnology
2012
Universidade de São Paulo
2007-2011
Universidade de Ribeirão Preto
2007
Background The malignant B cells in chronic lymphocytic leukemia receive signals from the bone marrow and lymph node microenvironments which regulate their survival proliferation. Characterization of these pathways that propagate them to interior cell is important for identification novel potential targets therapeutic intervention.Design Methods We compared gene expression profiles purified peripheral blood identify genes are induced by microenvironment. Two differentially expressed were...
Summary. Haemophilia A is an X‐linked, recessively inherited bleeding disorder of varying severity, which results from the deficiency procoagulant factor VIII f ( 8 ). Linkage diagnosis using polymorphic markers in f8 gene widely used to detect carriers. The objective this study was verify informativeness three Brazilian population, evaluate usefulness such carrier detection procedures. Sixty‐three unrelated healthy volunteers and 10 haemophilic families were studied. Two microsatellite...
Nowadays, radiation technology is widely used to produce changes in Biosystems.The goal of this work determine the variation induced male Pectinophora gossypiella gamma-irradiated as pupae using 50Gy and 150Gy.Comparing elements composition DNA (using RAPD-PCR) between substerile sterile dose 150Gy P. showed them.Potassium (K) was most abundant unirradiated irradiated males followed by magnesium (Mg).The percentage heavy metals copper, zinc, cadmium concurrent with K directly proportional...
Abstract Objectives Verify the in-vitro effect of triiodothyronine (T3) on chondrogenic differentiation female rat bone marrow mesenchymal stem cells (BMMSCs) over several time periods and at doses. Methods CD54 + /CD73 /CD90 BMMSCs from Wistar rats were cultured in medium with or without T3 (0.01; 1; 100; 1000 nm). At seven, 14 21 days, cell morphology, matrix formation expression Sox9 collagen II evaluated. Key findings The dose 100 nm did not alter parameters evaluated any studied....
Euphorbia tirucalli , a plant commonly known as aveloz, has been employed in anticancer therapy with little scientific proof. The goal of this study was to evaluate the cytotoxic potential and expression caspase-3 p53 colorectal cancer cell lines treated aveloz extracts. Hexanic hydroalcoholic extracts were prepared different concentrations. After 96 h, viability apoptosis rate (p53 expression) verified. hexanic extract revealed higher cytotoxicity on HCT-116 line at concentrations above 125...
Cutaneous and visceral leishmaniasis are public health problems in Africa, Asia, Europe, America. The treatment has a high cost toxicity. Thus, this work aims to evaluate the leishmanicidal activity of alpha-bisabolol its three synthetic derivatives, P1, P2, P3, on promastigotes amastigotes Leishmania infantum L. amazonensis forms. Alpha-bisabolol showed lowest IC50 with 3.43 for promastigotes, while P1 was most toxic an 9.10. derivative P3 better amastigote form, 3.39 amazonensis. All...
Wound dressings can support healing by acting as physical barriers and drug delivery systems. The present study aimed to evaluate the biological activity of films containing pomegranate peel extract at 1.25% w/w prepared electrospinning technique for use wound dressing. was subjected an in vitro cytotoxicity assay using fibroblasts. formation fibers confirmed scanning electron microscopy. Biocompatibility analyzed determining hemolysis index, while susceptibility bacterial strains a fungus...
As leishmanioses são um conjunto de doenças causadas por protozoários do gênero Leishmania, transmitidas meio hábitos hematófagos fêmeas dípteros infectados, pertencentes à subfamília Phlebotominae. É uma doença negligenciada e grande relevância devido sua incidência letalidade quando não tratada. O tratamento das é obstáculo, alta toxidade efeitos adversos causados pelos fármacos disponíveis. Neste sentido, as plantas medicinais têm ganhado destaque na busca que possam apresentar menos...
ABSTRACT: The objective of this study was to investigate the in vitro action triiodothyronine (T3) on chondrogenic differentiation adipose tissue-derived stem cells (ASCs) female rats, with different time periods and doses. ASCs were extracted from Wistar rats cultured medium without presence T3. Five groups established: 1) T3; 2,3,4,5) 0.01, 1, 100 1,000 nM T3, respectively). After 7, 14 21 days, cell morphology, matrix formation, expression Sox9, aggrecan, collagen II, X evaluated....