A5042384178- DNA and Nucleic Acid Chemistry
- RNA and protein synthesis mechanisms
- Protein Structure and Dynamics
- Advanced biosensing and bioanalysis techniques
- Computational Drug Discovery Methods
- Origins and Evolution of Life
- Chemical Synthesis and Analysis
- Drug Transport and Resistance Mechanisms
- Supramolecular Self-Assembly in Materials
- Analytical Chemistry and Chromatography
- History and advancements in chemistry
- Genetics, Bioinformatics, and Biomedical Research
- RNA modifications and cancer
- Chemical Reaction Mechanisms
- Pharmacogenetics and Drug Metabolism
- Surfactants and Colloidal Systems
- Advanced Drug Delivery Systems
- Click Chemistry and Applications
- Plant Pathogens and Fungal Diseases
- Organic Chemistry Cycloaddition Reactions
- Mycotoxins in Agriculture and Food
- Education and Military Integration
- Bacteriophages and microbial interactions
- Environmental, Ecological, and Cultural Studies
- Pharmacological Effects of Natural Compounds
John D. and Catherine T. MacArthur Foundation
2022
Emory University
2011-2021
AID Atlanta
2021
University of Chicago
1994-2017
Foundation for Applied Molecular Evolution
2012
United States Navy
2012
United States Naval Academy
2012
United States Department of the Navy
2012
Institute for Educational Leadership
2012
United States Army
2012
The relationship of rotatable bond count (N(rot)) and polar surface area (PSA) with oral bioavailability in rats was examined for 434 Pharmacia compounds compared an earlier report from Veber et al. (J. Med. Chem. 2002, 45, 2615). N(rot) PSA were calculated QikProp or Cerius2. resulting correlations depended on the calculation method therapeutic class within data superset. These results underscore that such generalizations must be used caution.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTemplate-directed synthesis: use of a reversible reactionJay T. Goodwin and David G. LynnCite this: J. Am. Chem. Soc. 1992, 114, 23, 9197–9198Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/ja00049a067https://doi.org/10.1021/ja00049a067research-articleACS PublicationsRequest reuse permissionsArticle Views1082Altmetric-Citations125LEARN ABOUT...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of the Fusarium toxin equisetin: use phenylboronates in structure assignmentN. J. Phillips, T. Goodwin, A. Fraiman, R. Cole, and D. G. LynnCite this: Am. Chem. Soc. 1989, 111, 21, 8223–8231Publication Date (Print):October 1, 1989Publication History Published online1 May 2002Published inissue 1 October 1989https://pubs.acs.org/doi/10.1021/ja00203a025https://doi.org/10.1021/ja00203a025research-articleACS PublicationsRequest reuse...
The relationship of solute structure with cellular permeability was probed. Two series dipeptide mimetics consisting glycine, alanine, valine, leucine, phenylalanine, and cyclohexylalanine amino acids in the D-configuration were prepared. Partition coefficients for peptidemimetics obtained octanol/water (log P(octanol/water)), hydrocarbon/octanol (Delta log P), heptane/ethylene glycol P(heptane/glycol)) systems order to explore contributions volume, or surface area, hydrogen-bond potential...
Biology encodes hereditary information in DNA and RNA, which are finely tuned to their biological functions modes of production. The central role nucleic acids flow makes them key targets pharmaceutical research. Indeed, other acid-like polymers can play similar roles natural both vivo vitro; yet despite remarkable advances over the last few decades, much remains unknown regarding structures compatible with molecular storage. Chemical space describes properties molecules that could exist...
Disulfide cross-links have been site-specifically incorporated into unmodified yeast tRNAPhe by total chemical synthesis. One cross-link is between positions 1 and 72 in the amino-acid acceptor stem, it was prepared replacing G1 C72 with N3-(thioethyl)uridine. A second central D-region of 11 25, synthesized C11 C25 2'-O-alkylthiol modified cytosine residues. Air oxidation to form at both sites occurs 12 h nearly quantitative. Analysis cross-linked products native denaturing PAGE along Pb(II)...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE USE OF SODIUM IN THE PREPARATION METHYLENE-LINKED SILANESJ. T. Goodwin Jr., W. E. Baldwin, and R. McGregorCite this: J. Am. Chem. Soc. 1947, 69, 9, 2247Publication Date (Print):September 1, 1947Publication History Published online1 May 2002Published inissue 1 September 1947https://pubs.acs.org/doi/10.1021/ja01201a521https://doi.org/10.1021/ja01201a521research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Phenylation and Methylation of Alkoxychlorosilanes1C. C. CHAPPELOW Jr., R. L. ELLIOTT, J. T. GOODWIN Jr.Cite this: Org. Chem. 1960, 25, 3, 435–439Publication Date (Print):March 1, 1960Publication History Published online1 May 2002Published inissue 1 March 1960https://pubs.acs.org/doi/10.1021/jo01073a033https://doi.org/10.1021/jo01073a033research-articleACS PublicationsRequest reuse permissionsArticle Views325Altmetric-Citations17LEARN ABOUT...
Ribonucleic acid (RNA) is one of the two nucleic acids used by extant biochemistry and plays a central role as intermediary carrier genetic information in transcription translation. If RNA was involved origin life, it should have facile prebiotic synthesis. A wide variety such syntheses been explored. However, to date no one-pot reaction has shown capable yielding monomers from likely prebiotically abundant starting materials, though this does not rule out possibility that simpler, more...
Abstract: The therapeutic efficacy of an orally administered drug is dictated not only by its pharmacological properties such as potency and selectivity, but also pharmacokinetic access to the site activity. Thorough evaluation physicochemical biological barriers delivery essential selection successful development candidates. We have demonstrated previously that cellular permeability, a primary component delivery, principally dependent upon desolvation potential polar functionalities in...
The RNA world hypothesis simplifies the complex biopolymer networks underlining informational and metabolic needs of living systems to a single scaffold. This simplification requires abiotic reaction cascades for construction RNA, this chemistry remains subject active research. Here, we explore complementary approach involving design dynamic peptide capable amplifying encoded chemical information setting stage mutualistic associations with RNA. Peptide conformational are known be evolution...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of t-Butylsilicon Compounds by the Wurtz-Fitting Reaction1C. C. CHAPPELOW Jr., R. L. ELLIOTT, and J. T. GOODWIN Jr.Cite this: Org. Chem. 1962, 27, 4, 1409–1414Publication Date (Print):April 1, 1962Publication History Published online1 May 2002Published inissue 1 April 1962https://doi.org/10.1021/jo01051a069RIGHTS & PERMISSIONSArticle Views317Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are COUNTER-compliant sum full text...
Substrate initiated assembly of a dynamic chemical network.
A multilaboratory study was conducted to compare performance of the GeneQuence DNA hybridization (DNAH) method incorporating new 24 h enrichment protocols and reference culture procedures for detection Salmonella spp. in select foods. Six food types (raw ground turkey, raw beef, dried whole egg, milk chocolate, walnuts, dry pet food) were tested by DNAH methods either U.S. Department Agriculture-Food Safety Inspection Service (USDA-FSIS) or Food Drug Administration's Bacteriological...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationProbing the Structure of an RNA Tertiary Unfolding Transition StateEmily J. Maglott, Jay T. Goodwin, and Gary D. GlickView Author Information Department Chemistry, University Michigan Ann Arbor, 48105-1055 Cite this: Am. Chem. Soc. 1999, 121, 32, 7461–7462Publication Date (Web):August 3, 1999Publication History Received23 April 1999Published online3 August inissue 1...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImproved Solid-Phase Synthesis of Long Oligoribonucleotides: Application to tRNAphe and tRNAglyJay T. Goodwin, Wendy A. Stanick, Gary D. GlickCite this: J. Org. Chem. 1994, 59, 26, 7941–7943Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/jo00105a001https://doi.org/10.1021/jo00105a001research-articleACS PublicationsRequest reuse...