Abstract Powdered tobacco (Khaini tobacco) with the addition of lime is commonly used by residents Bihar, India. The tobacco/lime mixture usually placed on inner side lower lip within gingivolabial groove. About 42% users keep it at front, rest move towards left or right oral cavity. Carcinomas (so‐called “Khaini cancers”) develop mainly site where in close contact mucosa. Scrapings mucosa were taken sites kept, then smears prepared, stained Feulgen reaction and fast green, screened for...

A convenient method for preparing attractively functionalized 1,4-diketones has been devised by palladium-catalyzed cross-coupling of cyclopropanols and acyl chlorides. The utility this demonstrated in an enantioselective synthesis (+)-myrmicarin 217.

In recent years, the maleimide scaffold has received a great deal of attention in C–H activation.

Abstract 1,4‐Naphthoquinones (1,4‐NQs) are an important class of molecules with diverse pharmaceutical applications. Lawsone, a naturally occurring molecule range bioactivities, falls in the 1,4‐NQs. It possesses 1,3‐dicarbonyl functionality, which has been utilized synthesis bis‐lawsones reaction aldehydes. In this review we have discussed notable developments bis‐lawsone from 2009 to 2023. Also, highlights limitations and future perspectives area.

In the iodine–DMSO medium, methyl group of azaarenes is converted into aldehyde via Kornblum oxidation and trapped in situ by nucleophiles to create azaarene-linked functionalized scaffolds.

Abstract The growing pollution and threat to the environment demand green synthetic methods. Green chemistry mainly focuses on minimizing waste utilization of solvents, energy sources, catalysts prefers one‐pot reactions. In this context, humic acid (HA), a natural bioorganic catalyst found in rivers, peat coal sewage; is high molecular weight macromolecule containing multifunctional groups, contains quinone, phenolic OH, COOH groups which make it acidic activate carbonyl by protonation....

Lawsone is a popular bioactive natural product. 1,3-Thiazoles are also widely distributed in many products, FDA-approved drugs, and functional materials. We report herein the first synthesis of naturally occurring lawsone-linked fully substituted 1,3-thiazoles one-pot multicomponent reaction (MCR) arylglyoxals, lawsone, thiobenzamides acetic acid at 90 °C, affording lawsone-1,3-thiazole hybrids excellent yields short times. The advantages present method include facile, robust, easy access to...

Abstract “Reverse”‐cigar smokers (who hold the burning end of cigars within mouth), dippers place a mixture Khaini‐tobacco and slaked lime into lower gingival groove) users tobacco‐containing toothpaste (gudakhu) in Orissa, India, were examined for precancerous oral lesions, frequency micronucleated cells at 3 different intra‐oral sites, levels tobacco‐specific nitrosamines (TSNA) saliva. Among reverse‐cigar smokers, high incidence leukokeratosis nicotina palati, an elevated palate (2.5% as...

The reflex increase in ventilation (Ve) produced by natural stimulation of certain sensory receptors gastrocnemius muscle was studied dogs anesthetized with Na pentobarbital. Reflex Ve occurred when the endings group III fibers and nonmedullated were stimulated (by stretching, pressing, or squeezing locally), whereas I II blocked repetitive antidromic stimulation. Stimulation alone also increased after all medullated either cooling medial nerve to 5 C stimulating lateral repetitively. It...

A green and sustainable approach has been developed using a recyclable reusable LaF 3 ·Pd nanocatalyst. This catalyst applied in the synthesis of biaryls good to excellent yields via Suzuki coupling aqueous medium.

A practical and enantioselective total synthesis of hyacinthacine A1 is achieved involving syn allylic epoxide opening with retention using Pd catalysis “domino” hydrogenation (five steps in one pot) sequences.

A new synthetic method for indolizidine or pyrrolizidine alkaloids based on readily available and attractively functionalized cyclopropanols, as exemplified in concise syntheses of (−)-223AB, its 3-epimer, (−)-indolizidine 239AB, 239CD, is reported. This work highlights the applications SN2′ alkylation C-acylation cyclopropanols to meet stereochemical challenges natural product synthesis. Also included diastereoselective cyclization resulting aminoallene adduct bicyclic ring formation.

C(sp)-H Bond activation of acetylene molecule still remains a challenge for synthetic organic chemists. In practice, acetylenes are activated by strong bases and metals. The first example activating acetylenic protons under base metal-free conditions is reported here. It involves general method synthesizing propargylic derivatives cotarnine. An array tetrahydroisoquinolines alkaloids was synthesized bond aromatic with cotarnine at room temperature. A DFT-based mechanism proposed the reaction.

A stereoselective route to the thermodynamically unfavorable 2,6-trans-tetrahydropyrans has been developed from coupling of hydroxyethyl-tethered cyclopropanols and aliphatic aldehydes. Noteworthy is high convergency direct two segments.

Abstract The Kulinkovich cyclopropanation of esters with disubstituted homoallylic alcohols is described for the preparation 1,2,3‐trisubstituted cyclopropanols. Central to successful implementation generation in situ a temporary alkoxy tether between alcohol and an alkoxytitanium species override unfavorable steric factors.

The reaction of cotarnine and acyl/aryl ketones in “green” solvents provides an efficient approach to array privileged 1,2,3,4‐tetrahydroisoquinolines excellent yields by metal‐free activation C(sp 3 )–H bonds. This one‐pot procedure takes place under base‐free conditions at room temperature, tolerates a wide range functionalities. is highly chemoselective, can be performed on multi‐gram scale, pure products are isolated simple filtration without workup. Interestingly, the complementary...

Infection of the sacroiliac joint is a rare entity. Clinical signs and symptoms are usually nonspecific result in delayed diagnosis. We report case primary meningococcal arthritis right an 11-year-old male child. Synovial fluid aspirated from space showed Gram-negative diplococci which were confirmed as Neisseria meningitidis by culture necessary biochemical tests followed serogrouping using polyvalent antisera. He was treated successfully with antibiotics.

Regioselective ring opening of cyclopropanols by the use organozinc reagents or ZnI2 is presented.Mechanistic studies are discussed with respect to possible involvement zinc ketone homoenolates.