A5077767218- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- Metabolism and Genetic Disorders
- Reproductive Biology and Fertility
- Retinal Development and Disorders
- RNA regulation and disease
- Folate and B Vitamins Research
- Retinal Diseases and Treatments
- Tissue Engineering and Regenerative Medicine
- Reproductive Physiology in Livestock
- Genomics and Rare Diseases
- Viral gastroenteritis research and epidemiology
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Animal health and immunology
- Sperm and Testicular Function
- Renal and related cancers
- Genomic variations and chromosomal abnormalities
- Ocular Disorders and Treatments
Ghent University
2021-2024
Ghent University Hospital
2019-2021
Abstract Background Within the follicular fluid, extracellular vesicles (EVs) guide oocyte growth through their cargo microRNAs (miRNAs). Here, we investigated role of EVs and miRNAs by linking found in EVs, derived from fluid an individual follicle, to ability its become a blastocyst (competent) or not (non-competent). Methods Bovine antral follicles were dissected, categorized as small (2–4 mm) large (5–8 corresponding oocytes subjected maturation, fertilization embryo culture stage....
MicroRNAs (miRNA) are important regulators of oocyte maturation, playing a key role in modulating gene expression both temporal- and spatial-specific manner. These small non-coding RNAs involved processes during acting as messengers between the its surrounding cumulus cells. Despite significance, bidirectional communication mechanism is still unknown. To test miRNA cells through gap junctions were either blocked with carbenoxolone or not. MiRNA sequencing oocytes at 1, 6, 22 h vitro...
Extracellular vesicles (EVs) contain microRNAs (miRNAs), which are important regulators of embryonic development. Nevertheless, little is known about the precise molecular processes controlling blastocyst development and quality. In a previous study, we identified bta-miR-665 as one miRNAs more abundantly present in extracellular embryo-conditioned culture media blastocysts compared to degenerate ones. Here, investigated effect regulatory roles by supplementation mimics or inhibitors media....
Background: Late-onset retinal degeneration (L-ORD) is a rare autosomal dominant dystrophy related to C1QTNF5 gene variants.Materials and methods: Twenty-six patients (21-81 years) with L-ORD due c.562C>A p.(Pro188Thr) mean follow-up time of 8 years (range 1-37 underwent an extensive ophthalmic work-up.Results: Best-corrected visual acuity (BCVA) fields were maintained up 50 55 (n = 8), gradual decline, but conservation functional central vision between 65 15), followed by steep decrease in...