A5013431969- Protein Tyrosine Phosphatases
- Endoplasmic Reticulum Stress and Disease
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Cancer, Hypoxia, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Protein Kinase Regulation and GTPase Signaling
- Autophagy in Disease and Therapy
- CAR-T cell therapy research
- Ubiquitin and proteasome pathways
- Immune Cell Function and Interaction
- RNA regulation and disease
- Heat shock proteins research
- Computational Drug Discovery Methods
- Macrophage Migration Inhibitory Factor
Research Institute in Oncology and Hematology
2025
CancerCare Manitoba
2025
University of Manitoba
2024
Purdue University West Lafayette
2020-2024
Center for Cancer Research
2021
Abstract Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) is an immature subtype of acute lymphoblastic leukemia (T-ALL) commonly show deregulation the LMO2-LYL1 stem cell transcription factors, activating mutations cytokine receptor signaling, and poor early response to intensive chemotherapy. Previously, studies Lmo2 transgenic mouse model ETP-ALL identified a population stem-like progenitors with long-term self-renewal capacity intrinsic chemotherapy resistance linked...
Tumor suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10) levels are frequently found reduced in human cancers, but how is down-regulated not fully understood. In addition, although a compelling connection exists between PRL of regenerating liver) 2 cancer, this phosphatase induces oncogenesis has been an enigma. Here, we discovered that PRL2 ablation inhibits heterozygosity-induced tumorigenesis. deficiency elevates attenuates AKT signaling, leading to decreased...
VCP/p97 is an evolutionarily conserved AAA+ ATPase important for cellular homeostasis. Previous studies suggest that VCP predominantly exists as a homohexamer. Here, we performed structural and biochemical characterization of dodecamer, understudied state VCP. The structure revealed apo nucleotide status has rarely been captured, tail-to-tail assembly two hexamers, the up-elevated N-terminal domains akin to seen in ATP-bound hexamer. Further analyses elucidated status-dependent...
The risk of developing Alzheimer's disease is associated with genes involved in microglial function. Inositol polyphosphate-5-phosphatase (
ABSTRACTOverexpression of PTP4A phosphatases are associated with advanced cancers, but their biological functions far from fully understood due to limited knowledge about physiological substrates. VCP is implicated in lysophagy via collaboration specific cofactors the ELDR complex. However, how complex assembly regulated has not been determined. Moreover, functional significance penultimate and conserved Tyr805 phosphorylation established. Here, we use an unbiased substrate trapping mass...
<title>Abstract</title> Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) is characterised by aberrant expression of the LMO2-LYL1 stem-cell transcription factor complex, activating mutations cytokine receptor signalling and poor response to intensive chemotherapy. Previously, studies Lmo2 transgenic mouse model ETP-ALL identified a population stem-like progenitors with long-term self-renewal capacity intrinsic chemoresistance linked cellular quiescence. Here, analyses mice,...