A5100333309- T-cell and B-cell Immunology
- vaccines and immunoinformatics approaches
- Invertebrate Immune Response Mechanisms
- Aquaculture disease management and microbiota
- Toxin Mechanisms and Immunotoxins
- Immunotherapy and Immune Responses
- Phagocytosis and Immune Regulation
- Advanced Chemical Sensor Technologies
- Toxoplasma gondii Research Studies
- Parasitic Infections and Diagnostics
- Aquaculture Nutrition and Growth
- Hepatitis C virus research
- Cytokine Signaling Pathways and Interactions
- RNA Research and Splicing
- Immune Response and Inflammation
- T-cell and Retrovirus Studies
- interferon and immune responses
- Transgenic Plants and Applications
- Mosquito-borne diseases and control
- Galectins and Cancer Biology
- Malaria Research and Control
China Agricultural University
2019-2022
UNC Lineberger Comprehensive Cancer Center
2022
World Wide Web Consortium
2007
Chinese Academy of Fishery Sciences
2007
The African clawed frog, Xenopus laevis, is a model species for amphibians. Before metamorphosis, tadpoles do not efficiently express the single classical MHC class I (MHC-I) molecule Xela-UAA, but after adults this in abundance. To elucidate Ag-presenting mechanism of study, Xela-UAA structure complex (pXela-UAAg) bound with peptide from synthetic random library was determined. amino acid homology between and MHC-I sequences different <45%, these differences are fully reflected...
Abstract Cartilaginous fish are the most primitive extant species with MHC molecules. Using nurse shark, current study is, to best of our knowledge, first present a peptide-loaded class I (pMHC-I) structure for this animals. The overall was found be similar between cartilaginous and bony animals, showing remarkable conservation interactions three pMHC-I components H chain, β2-microglobulin (β2-m), peptide ligand. In previous studies, relatively little attention given details binding chain...
Polymorphisms can affect MHC-I binding peptide length preferences, but the mechanism remains unclear. Using a random library combined with LC-MS/MS and de novo sequencing (RPLD-MS) technique, we found that two swine molecules high sequence homology, SLA-1*04:01 SLA-1*13:01, had significant differences in preference of peptides. Compared SLA-1*04:01, SLA-1*13:01 binds fewer short peptides 8-10 amino acids, more long A dodecapeptide (RW12) bind to both their crystal structures indicate modes...