A5083854035- T-cell and B-cell Immunology
- Electromagnetic Fields and Biological Effects
- vaccines and immunoinformatics approaches
- Meat and Animal Product Quality
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Metabolism, Diabetes, and Cancer
- Virus-based gene therapy research
- Hepatitis B Virus Studies
- Viral Infections and Vectors
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Noise Effects and Management
- interferon and immune responses
- Growth Hormone and Insulin-like Growth Factors
- Memory and Neural Mechanisms
- Pancreatic function and diabetes
- Protein Hydrolysis and Bioactive Peptides
- Clostridium difficile and Clostridium perfringens research
- Thermoregulation and physiological responses
- Sexual Differentiation and Disorders
- Diabetes Treatment and Management
- Neural dynamics and brain function
- Nutrition, Health and Food Behavior
Beijing Radiation Center
2021-2025
Tianjin Agricultural University
2011-2024
Hangzhou First People's Hospital
2009-2024
Zhejiang University
2019-2024
China Agricultural University
2017-2023
Chinese Academy of Agricultural Sciences
2016-2019
Shanghai Veterinary Research Institute
2017
Southern Medical University
2011-2016
Nanjing Medical University
2010-2015
Jiangmen Central Hospital
2013
ABSTRACT The annual increase of microwave exposure in human environments continues to fuel debates regarding its potential health impacts. This study monitored the EEG and ECG responses three Cynomolgus monkeys before at 0, 3, 7, 14, 30 days after 50 mW/cm² radiation for 15 min. findings revealed no significant differences power spectral densities (PSDs) whole brain, frontal, temporal lobes across various frequency bands (δ, θ, α, β, low‐γ, high‐γ) immediately up postexposure. Notable...
ABSTRACT The potential effects of microwave radiation have gained increasing attention due to its widespread application in daily life. This study aimed investigate on rat immune function. Male Wistar rats were subjected 2.856 GHz for 20 min. Cytokine levels serum measured by ELISA at 0 and 7 days' post‐exposure. HE staining was used observe the structure spleen. Morphology proliferation spleen mixed lymphocytes detected after 24 h culture, evaluated CCK‐8 assay. Expression HSP70...
Bats are natural reservoir hosts, harboring more than 100 viruses, some of which lethal to humans. The asymptomatic coexistence with viruses is thought be connected the unique immune system bats. MHC class I (MHC I) presentation closely related cytotoxic lymphocyte immunity, plays an important role in viral resistance. To investigate characteristics bats, crystal structures peptide-MHC complexes Pteropus alecto, Ptal-N*01:01/HEV-1 (DFANTFLP) and Ptal-N*01:01/HEV-2 (DYINTNLVP), two mutants,...
ABSTRACT Feline immunodeficiency virus (FIV) infection in domestic cats is the smallest usable natural model for lentiviral studies. FLA-E*01801 was applied to FIV AIDS vaccine research. We determined crystal structure of complexed with a peptide derived from (gag positions 40 48; RMANVSTGR [RMA9]). The A pocket complex plays valuable restrictive role binding. Mutation experiments and circular-dichroism (CD) spectroscopy revealed that peptides Asp at first position (P1) could not bind...
We aim to evaluate the efficacy and safety of pioglitazone/metformin fixed-dose combination (FDC) versus uptitrated metformin in patients with type 2 diabetes mellitus (T2DM) without adequate glycemic control.
Aims Metformin treatment for type 2 diabetes mellitus (T2DM) can be limited by gastrointestinal (GI) adverse events (AEs), resulting in discontinuation. We investigated whether once‐daily metformin extended release (XR) is superior terms of GI tolerability, with non‐inferior efficacy, compared thrice‐daily immediate (IR) treatment‐naïve Chinese patients T2DM. Materials and Methods This prospective, open‐label, randomized, multicentre, phase IV interventional study enrolled T2DM to receive...
The African clawed frog, Xenopus laevis, is a model species for amphibians. Before metamorphosis, tadpoles do not efficiently express the single classical MHC class I (MHC-I) molecule Xela-UAA, but after adults this in abundance. To elucidate Ag-presenting mechanism of study, Xela-UAA structure complex (pXela-UAAg) bound with peptide from synthetic random library was determined. amino acid homology between and MHC-I sequences different <45%, these differences are fully reflected...
MHC class II (MHC-II) molecules play a crucial role in cellular and humoral immunity by forming peptide-MHC-II (pMHC-II) complexes. The three-dimensional structures of pMHC-II complexes have been well resolved humans mice. However, there is no structural information for nonmammals. In chickens, are two closely related highly polymorphic β-chains one monomorphic α-chain, the mechanism which α-chain combines with to form functional heterodimer remains unknown. this study, we report crystal...
To investigate CTL epitope applications in swine, SLA-1*1502-restricted peptide epitopes matching porcine reproductive and respiratory syndrome virus (PRRSV) strains were explored by crystallography, biochemistry the specific pathogen-free (SPF) swine experiments. First, nine predicted PRRSV peptides tested assembly of peptide-SLA-1*1502 (pSLA-1*1502) complexes, crystal structure SLA-1*1502 complex with one (NSP9-TMP9) was determined. The NSP9-TMP9 conformation presented pSLA-1*1502 is...
Lethal infections by strains of the highly-pathogenic avian influenza virus (HPAIV) H5N1 pose serious threats to both poultry industry and public health worldwide. A lack confirmed HPAIV epitopes recognized cytotoxic T lymphocytes (CTLs) has hindered utilization CD8+ T-cell–mediated immunity precluded development effectively diversified epitope-based vaccination approaches. In particular, an CTL-recognized epitope based on peptide MHC-I–β2m (pMHC-I) complex not yet been designed. Here,...
Contemporary antigen presentation knowledge is based on the existence of a single β2m locus, and classical MHC class I forms complex with peptide (i.e., pMHC-I) to trigger CTL immunity. However, two loci have been found in diploid bony fish; function molecules unclear. Here, we determined variant profiles originating from different products binding same MHC-I molecule further solved crystal structures pMHC-I pCtid-UAA-β2m-2 pCtid-UAA-β2m-1-II). Of note, pCtid-UAA-β2m-2, unique hydrogen bond...
It is well known that immunization of radiation-attenuated (RA) schistosoma cercariae or schistosomula can induce high levels protective immunity against reinfection in many animals. Many studies have shown the Th1 cellular immune response crucial for effect elicited by RA schistosomula. However, molecular mechanism this strong remains unclear. The expression profiles Schistosoma japonicum calreticulin (SjCRT) and normal schistosoma-derived cells were investigated flow cytometry. recombinant...
Evidence shows that microwaves radiation may have various biological effects on central nervous system. Role of electromagnetic fields in neurodegenerative diseases, especially AD, has been widely studied, but results these studies are inconsistent. Therefore, the above were verified again and mechanism was preliminarily discussed. Amyloid precursor protein (APP/PS1) WT mice exposed to long-term microwave for 270 days (900 MHz, SAR: 0.25–1.055 W/kg, 2 h/day, alternately), related indices...