A5059558422- dental development and anomalies
- Forensic Anthropology and Bioarchaeology Studies
- Cleft Lip and Palate Research
- Oral microbiology and periodontitis research
- Orthodontics and Dentofacial Orthopedics
- Morphological variations and asymmetry
- Genetic and phenotypic traits in livestock
- Dental Health and Care Utilization
- Forensic and Genetic Research
- Dental Radiography and Imaging
- Gut microbiota and health
- Medical and Biological Sciences
- Bone and Dental Protein Studies
- HIV/AIDS oral health manifestations
- Sexual Differentiation and Disorders
- Dental Trauma and Treatments
- Dermatoglyphics and Human Traits
- Dental materials and restorations
- Temporomandibular Joint Disorders
- Craniofacial Disorders and Treatments
- Urological Disorders and Treatments
- Genetic Syndromes and Imprinting
- Assisted Reproductive Technology and Twin Pregnancy
- Genetic Associations and Epidemiology
- Hydraulic Fracturing and Reservoir Analysis
The University of Adelaide
2014-2025
Pennsylvania State University
1981-2024
The University of Sydney
2023
The University of Melbourne
2020
Murdoch Children's Research Institute
2020
The University of Texas at Dallas
2016
University of Liverpool
2008
The University of Queensland
2007
The University of Notre Dame Australia
2007
Nihon University
2004
Abstract Antibiotic overuse has promoted the spread of antimicrobial resistance (AMR) with significant health and economic consequences. Genome sequencing reveals widespread presence genes (ARGs) in diverse microbial environments. Hence, surveillance reservoirs, like rarely explored oral microbiome, is necessary to combat AMR. Here, we characterise development paediatric resistome investigate its role dental caries 221 twin children (124 females 97 males) sampled at three time points over...
Background: Comparisons between monozygotic (MZ) co-twins have tended to focus on the similarities their dentitions rather than differences. The aim of this study was determine prevalence discordant expression for simple hypodontia and supernumerary teeth in MZ twin pairs explain how phenotypic differences might occur despite similar genotypes. Methods: Records 278 twins, including dental casts radiographs, were examined prevalences missing upper lateral incisors (ULI) or second premolars...
Oral health has substantial economic importance, with over $100 billion spent on dental care in the United States annually. The microbiome plays a critical role oral health, yet remains poorly classified. To address question of how microbial diversity and function cavities children relate to caries diagnosis, we surveyed supragingival plaque biofilm 44 juvenile twin pairs. Using shotgun sequencing, constructed genome encyclopedia describing core microbiome. This unveiled several new...
Our understanding of tooth eruption in humans remains incomplete. We hypothesized that genetic factors contribute significantly to phenotypic variation the emergence primary incisors. applied model-fitting data from Australian twins quantify contributions and environmental timing human There were no significant differences incisor times between zygosity groups or sexes. Emergence maxillary central incisors mandibular lateral less variable than those Maxillary displayed directional asymmetry,...
The human dentition is a complex adaptive system that influenced by genetic, epigenetic, and environmental factors. Within this system, sexual dimorphism related to the growth promotion of Y chromosome, or hormonal influences, both? This study first investigate both primary permanent tooth sizes in females from opposite-sex dizygotic (DZOS) twin pairs compared with same-sex (DZSS) monozygotic (MZ) indicate influence intrauterine male hormone, including initial testosterone surge, on dental...
Abstract Humans are host to a multitude of microorganisms that rapidly populate the body at birth, subject complex interplay is dependent on genetics, lifestyle, and environment. The host-associated microbiome, including oral presents itself in ecosystem important health disease. As most common chronic disease globally, dental caries induced by host-microbial dysbiosis children adults. Multiple biological environmental factors likely impact predisposition, onset, progression, severity, yet...
Background/Objectives: The development of dental arches is a complex adaptive system with interactions between genetic and environmental factors. At different developmental stages, the relative contribution these factors varies. aims this project were to identify longitudinal changes in primary, mixed permanent dentition using curve fitting methods on serial casts, investigate genotype arch development. Methods: Longitudinal records from 125 monozygotic same-sex twin pairs, 89 dizygotic 49...
Abstract Introduction Forensic dental identification relies on the comparison of antemortem and postmortem records. 3D imaging presents potential for detailed anatomical features teeth to be quantified between individuals in automated tools. This study introduces a novel segmentation method simultaneously remove extraneous data from two images reducing processes time required during image comparisons, tests this against existing approaches better understand techniques forensic purposes....
Abstract Objective This study aimed to estimate the relative contributions of genetic and environmental factors phenotypic variations dental arch traits from primary permanent dentition stages. Methods Digital models 188 Australian twin pairs (90 monozygotic 98 dizygotic) in stage, followed up through mixed stages, were included study. Landmarks identified on both maxillary mandibular arches MeshLab for measuring intercanine widths, intermolar lengths, overjet, overbite molar relationships....
Molecular studies indicate that epigenetic events are important in determining how the internal enamel epithelium folds during odontogenesis. Since this process of folding leads to subsequent arrangement cusps on molar teeth, we hypothesized intercuspal distances human teeth would display greater phenotypic variation but lower heritabilities than overall crown diameters. Intercuspal and maximum diameters were recorded from digitized images dental casts 100 monozygotic 74 dizygotic twin...
Children's oral health is in a dire state, with dental decay (caries) being one of the most common chronic diseases. While role bacteria microbiome and caries established, contribution fungi relatively unknown. We assessed mycobiome childhood (n = 17), to determine if composition varies between children without caries. Oral was by using Illumina MiSeq sequence ITS2 region, which amplified from plaque. This revealed that investigated contained 46 fungal species. Candida albicans abundant...
Human identification via dental comparison is only possible if sufficient antemortem records are available. These sourced from practices. New 3D digital technologies increasingly being used by dentists in Australia for routine clinical procedures and offer significantly more data individualizing people than traditional 2D records. However, it uncertain whether clinicians aware of the importance these forensic purposes. The collection practices critical to successful odontology. A survey...
Teeth are a valuable source of DNA for identification fragmented and degraded human remains. While the value dental pulp as is well established, quantity presentation in hard tissues has not been extensively studied. Without this knowledge common decontamination, sampling extraction techniques may be suboptimal. Targeted specific could maximise profiling success, while minimising need laborious protocols techniques, thus improving workflows efficiencies. We aimed to determine location...
Information on the timing and sequence of human tooth emergence is valuable when analysing growth development, predicting age individuals, for understanding effects genetic environmental influences processes. This paper provides updated data primary in Australian children both clinicians researchers.Twins were recruited from around Australia with collected through parental recording twins' emergence. One twin each pair was then randomly selected to enable calculation descriptive statistics...
Abstract Objectives Rapid prototyping (RP) technology is becoming more affordable, faster, and now capable of building models with a high resolution accuracy. Due to technological limitations, 3D printing in biological anthropology has been mostly limited museum displays forensic reconstructions. In this study, we compared the accuracy different printers establish whether RP can be used effectively reproduce anthropological dental collections, potentially replacing access oftentimes fragile...
Abstract Objectives This study generates a series of narrow‐sense heritability estimates for crown morphology the deciduous and permanent dentition with two overarching aims. The first is to test hypothesis that teeth provide more faithful reflection genetic information than their successors. second use quantitative methods evaluate assumptions underlying common data collection analysis practices in biodistance research. Materials Methods Dental were collected from longitudinal dental casts...
The Craniofacial Biology Research Group in the School of Dentistry at University Adelaide is entering an exciting new phase its studies dental development and oral health twins their families. Studies teeth faces Australian have been continuing for nearly 30 years, with three major cohorts recruited over that time, currently we are working aged 2 years old to adults. Cross-sectional data records relating available around 300 pairs teenage twins, as well longitudinal examined different stages...