A5083873485- Salmonella and Campylobacter epidemiology
- Escherichia coli research studies
- Bacteriophages and microbial interactions
- Antibiotic Resistance in Bacteria
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Viral gastroenteritis research and epidemiology
- Microbial infections and disease research
- Cancer Research and Treatments
- Vibrio bacteria research studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Telomeres, Telomerase, and Senescence
- Medical Imaging Techniques and Applications
- Bacterial Genetics and Biotechnology
- Lung Cancer Treatments and Mutations
- Biotin and Related Studies
- Listeria monocytogenes in Food Safety
- Virus-based gene therapy research
- Trace Elements in Health
- Mycobacterium research and diagnosis
- Amino Acid Enzymes and Metabolism
- Cancer-related Molecular Pathways
- Genomics and Phylogenetic Studies
- Biopolymer Synthesis and Applications
- Oral microbiology and periodontitis research
National Institute of Animal Health
2015-2024
National Agriculture and Food Research Organization
2015-2024
Osaka Metropolitan University
2023-2024
Tokyo Metropolitan University
2023-2024
Imperial College London
2023
Hoshi University
2023
Osaka Prefecture University
2007-2022
Jikei University School of Medicine
2020
Laboratoire Mathématiques, Image et Applications
2020
NTL Institute for Applied Behavioral Science
2020
To determine the distribution and relationship of antimicrobial resistance determinants among extended-spectrum-cephalosporin (ESC)-resistant or carbapenem-resistant Escherichia coli isolates from aquatic environment in India, water samples were collected rivers sewage treatment plants five Indian states. A total 446 E. randomly obtained. Resistance to ESC and/or carbapenem was observed 169 (37.9%) isolates, which further analyzed. These showed numerous antimicrobials; more than half...
Salmonella enterica serovar Typhimurium (Salmonella Typhimurium) and its monophasic variant 4,[5],12:i:-) are the major causes of gastroenteritis in both humans animals. Pulsed-field gel electrophoresis multilocus variable-number tandem-repeat analysis have been used widely as subtyping methods for these pathogens molecular epidemiological analyses, but results do not precisely reflect phylogenetic information. In this study, we performed a serovars using whole-genome sequencing data...
Salmonella genomic island 3 (SGI3) was first described as a chromosomal in 4,[5],12:i:-, monophasic variant of enterica subsp. serovar Typhimurium. The SGI3 DNA sequence detected from 4,[5],12:i:- isolated Japan identical to that previously reported one across entire length 81 kb. consists 86 open reading frames, including copper homeostasis and silver resistance (CHASRI) an arsenic tolerance operon, addition genes related conjugative transfer replication or partitioning, suggesting the is...
ABSTRACT Enterohemorrhagic Escherichia coli O157 (EHEC O157) is a food-borne pathogen that has raised worldwide public health concern. The development of simple and rapid strain-typing methods crucial for the detection surveillance EHEC outbreaks. In present study, we developed multiplex PCR-based method O157, which based on variability in genomic location IS 629 among strains. This very simple, procedures are completed within 2 h, analysis can be performed without need special equipment or...
Fluoroquinolone resistance can cause major clinical problems. Here, we investigated fluoroquinolone mechanisms in a Escherichia coli isolate, HUE1, which had no mutations quinolone resistance-determining regions (QRDRs) of DNA gyrase and topoisomerase IV. HUE1 demonstrated MICs that exceeded the breakpoints for ciprofloxacin, levofloxacin, norfloxacin. harbored oqxAB qnrS1 on distinct plasmids. In addition, it exhibited lower intracellular ciprofloxacin concentrations higher mRNA expression...
Salmonella enterica subspecies serovar 4,[5],12:i:- (S. 4,[5]12:i:-) is believed to be a monophasic variant of S. Typhimurium Typhimurium). This study was conducted corroborate this hypothesis and identify the molecular phenotypic characteristics 4,[5]12:i:- isolates in Japan. A total 51 derived from humans, cattle, swine, chickens, birds, meat (pork), river water 15 prefectures Japan between 2000 2010 were analyzed. All identified as by two different polymerase chain reactions (PCR) for...
EnterotoxigenicEscherichia coli(ETEC) and Shiga toxin-producingE. coli(STEC) are important causes of diarrhea edema disease in swine. The majority swine-pathogenicE. colistrains belong to a limited range O serogroups, including O8, O138, O139, O141, O147, O149, O157, which the most frequently reported strains worldwide. However, circumstances ETEC STEC infections Japan remain unknown; there have been few reports on prevalence or characterization coli In present study, we determined...
The purpose of this study was to determine the time infection by anaerobic gram-negative rods associated with periodontal disease, and clarify their transmission from mother child.Seventy-eight Japanese children (including 10 siblings), aged 3 9 years, 68 mothers, were enrolled in study. Colonization 11 bacterial species determined using polymerase chain reaction amplification samples subgingival plaque obtained mothers.The detection rates Porphyromonas gingivalis, Tannerella forsythensis...
Since 2004, extended-spectrum cephalosporin (ESC)-resistant Salmonella enterica serovar Typhimurium (S. Typhimurium) isolates have been detected from cattle in the northern major island of Japan, Hokkaido. Resistance to ESCs was found be mediated by CMY-2 type β-lactamase among 22 epidemiologically unrelated showing indistinguishable pulsed-field gel electrophoresis patterns. Southern blot analysis using I-CeuI-digested genomic DNA demonstrated that gene (bla(CMY-2)) integrated a 2.5-Mb...
A key virulence factor of enterohaemorrhagic Escherichia coli (EHEC) is the bacteriophage-encoded Shiga toxin (Stx). Stxs are classified into two types, Stx1 and Stx2, Stx2-producing strains thought to cause more severe infections than producing only Stx1. Although O26 : H11 second most prevalent EHEC following O157 H7, majority produce alone. However, have increasingly been detected worldwide. Through a large-scale genome analysis, we present global phylogenetic overview evolutionary...
Campylobacter jejuni is a leading cause of foodborne bacterial gastroenteritis worldwide, and raw or undercooked chicken meat considered the major source human campylobacteriosis. In this study, we identified 36 compounds that showed inhibitory effects on C. growth at low concentrations by screening chemical compound library. Three were herbal compounds, including tryptanthrin (TRP), an indoloquinazoline alkaloid. TRP has been reported to have variety biological properties, such as...
Magnetic resonance (MR) imaging has both advantages and disadvantages in its application lung cancer staging. Because of ability to provide superior contrast resolution display structures many planes, MR is better than computed tomography (CT) for the detection mediastinal chest wall invasion. also more sensitive CT hilar lymph node enlargement. Multiplanar T1- T2-weighted images are optimal differentiating nodes from large vessels without need enhancement; these cases administration Gd-DTPA...
Halitosis is known as unpleasant oral odor and a health concern among the general public. Previously, we reported on new portable monitor with zinc-oxide, thin-film, semiconductor sensor which demonstrated simplicity of handling, high reproducibility correspondence for organoleptic assessment. The results suggested its usefulness diagnosis halitosis. Using monitor, air samples 94 subjects were measured in field survey, values compared rates corresponding assessed by two judges. A highly...
We report a patient with pancreatic cancer in whom telomerase activity had been detected the juice 19 months before he was diagnosed as having cancer. A 61-yr-old alcoholic man complaining of epigastric and back pain groove pancreatitis based on presence inflammation head its extension to duodenal mucosa an associated elevated serum amylase level. All imaging modalities showed no sign tumor. However, high collected during endoscopic retrograde pancreatography. His symptoms subsided due...