A5084261670- Radical Photochemical Reactions
- Oxidative Organic Chemistry Reactions
- Catalytic C–H Functionalization Methods
- Sulfur-Based Synthesis Techniques
- Synthesis and Biological Evaluation
- Cyclopropane Reaction Mechanisms
- CO2 Reduction Techniques and Catalysts
- Fluorine in Organic Chemistry
Hangzhou Normal University
2021-2024
This study describes a green and novel multi-component reaction for direct perfluoroalkylation/heteroarylation of [1.1.1]propellane with heteroarenes perfluoroalkyl iodines to diverse bicyclo[1.1.1]pentanes (BCPs).
Synthesis of bicyclo[1.1.1]pentane (BCP) heteroaryls continues to be a part the most important tasks in organic synthesis because they are significant class bioisosteres with universal applications drug discovery. However, substrate scope current multicomponent reactions is limited tertiary alkyl radicals and prefunctionalized (het)arenes due their intrinsic mechanisms, resulting decrease application value. Herein, we report straightforward alternative for (halo)alkyl BCP-heteroaryls from...
Aryl-substituted bicyclo[1.1.1]pentane (BCP-aryl) derivatives represent the most important bioisosteres of biaryl scaffolds and widely exist in numerous complex pharmaceutical molecules. The current synthetic method limitations using only tertiary radical precursors, prefunctionalized heteroarenes, toxic transition metals, expensive photocatalysts make it urgent to develop a more simple practical protocol. To confront enrich Minisci-type chemistry, herein, we disclose photocatalytic...
This study describes a pioneering visible-light-induced phosphine-catalyzed halogen-atom transfer (XAT) strategy that heralds new era in the difunctionalization of [1.1.1]propellane.
Photo-induced C–H functionalization for divergent synthesis of quinoxalin-2(1 H )-one derivatives using 2 O as an oxidant without a photocatalyst.
Herein, a protocol that combines heterogeneous catalysis and solar photocatalysis for the regioselective α-substitution of asymmetric ketones with quinoxalinones has been reported. The result indicates reaction is more likely to occur on α-carbon. This strategy provides green efficient way α-functionalization ketones. A singlet oxygen involved mechanism suggested transformation.