This study describes a green and sustainable photoinduced strategy for decarboxylative C–H (amino)alkylation of heteroarenes with carboxylic acids under metal- photosensitizer-free conditions.

This study demonstrates a strategy involving photoinduced energy transfer for decarboxylative Minisci C–H (amino)alkylation of heteroarenes employing diverse oxime esters (from carboxylic acids) as (amino)alkylating reagents.

Bicyclo[1.1.1]pentane (BCP) heteroaryls make up an important class of BCP derivatives in drug discovery. Herein, we report the visible-light-mediated synthesis cyanoisopropyl BCP-heteroaryls motifs from

Herein, we introduce an efficient and straightforward strategy for the selective C-H esterification alkylation of quinoxalin-2(1H)-ones with aldehydes. A key feature our study is ability to perform both using different types The reaction system highly compatible a range aldehydes, yielding C3-esterified C3-alkylated products in moderate-to-good yields. applicability this approach further enhanced by its scalability through continuous-flow synthesis, late-stage modification significant...

The first example of nickel(II)-catalyzed site-selective C-H bond trifluoromethylation arylamine in water is established. In this transformation, a coordinating activation strategy performed by the utilization picolinamide as directing group, and target products are obtained moderate to good yields. addition, catalyst-in-water system can be reutilized eight times with slight loss catalytic activity applied green, concise synthesis acid red 266. Furthermore, series control experiments verify...

Abstract The first example of rapidly three‐component cascade reaction quinoxalinones with unactivated alkenes and TMSN 3 under mild condition has been described. This approach provides a practical solution for the rapid modification enables new planning strategies synthesis bioactive organoazides. A radical mechanism is responsible this transformation. magnified image

This study describes a novel aqueous reaction for the synthesis of (<italic>Z</italic>)-enaminones through combination heterogeneous catalysis and photocatalysis.

This study demonstrates a metal-free cross-dehydrogenative coupling for direct para -C–H heteroarylation of anilines with quinoxalinones using air as the sole oxidant and H 2 O/DMSO solvent.

Herein, we report a mild and practical protocol for the α-perchloroalkyl β-heteroarylation of alkenes using available chloroform as dichloromethyl source via α-amino radical-mediated halogen-atom transfer. Various substrates are compatible under reaction conditions, providing corresponding products in moderate to good yields. This strategy gives an efficient convenient method introduction chloroalkyl motifs into N-heteroarenes. The control experiment demonstrates that radical generated situ...

This study describes an efficient and green approach for the synthesis of potentially bioactive pyrrolo[1,2- a ]quinoxalin-4(5 H )-ones with appreciable functional group tolerance wide substrate scope.

This study describes a pioneering visible-light-induced phosphine-catalyzed halogen-atom transfer (XAT) strategy that heralds new era in the difunctionalization of [1.1.1]propellane.

A photocatalytic C–N cross-coupling and deaminative fluorinating strategy has been developed to afford 3-fluoro-3-hydroxyoxindoles with wide functionality tolerance good yields.

Herein, a novel method for the gram-scale synthesis of (E)-quinoxalinone oximes through multicomponent reaction under mild conditions is described. Such transformation was performed transition-metal-free conditions, affording (E)-oximes in moderate-to-good yield recrystallization. Our methodology demonstrates successful combination Mannich-type and radical coupling, providing green practical approach potentially bioactive quinoxalinone-containing molecules.

We report a Minisci-type cross-dehydrogenative alkylation in an aerobic atmosphere using abundant and inexpensive cerium chloride as photocatalyst air oxidant. This photoreaction exhibits excellent tolerance to functional groups is suitable for both heteroarene alkane substrates under mild conditions, generating the corresponding products moderate-to-good yields. Our method provides alternative approach late-stage functionalization of valuable substrates.

The first example of a photoinduced rapid multicomponent cascade reaction aryldiazonium salts with unactivated alkenes and trimethylsilyl azide (TMSN3) under oxidant-free conditions is described. This approach provides the synthetic route for wide range unsymmetric azo compounds. compounds are obtained in good to excellent yields mild conditions. transformation applicable various alkenes, providing an alternative synthesis control experiment demonstrates that mechanism follows radical pathway.

Abstract Herein, a visible light‐mediated multicomponent radical cross‐coupling reaction of [1.1.1]propellane with N ‐heterocycles and disulfides is described. The mild conditions enabled the installation BCP motif in wide variety compounds absence photocatalyst, additive metal catalyst, excellent functional group tolerance, This methodology opens approach for synthesis potentially bioactive 1‐arylthiol‐3‐heteroaryl bicyclo[1.1.1]pentanes moderate to good yield.

Abstract A coordinating activation strategy for selective para amination of arylamine with pyrazole is developed. Various substrates are compatible, giving the corresponding products in moderate to good yields. This provides a practical solution efficient synthesis arylamine‐containing pharmacophores from simple starting materials. single electron transfer mechanism suggested this reaction.

The cobalt(III)-catalyzed C-H activation/cyclization of benzimidates and vinylene carbonate has been developed. Various are well compatible, providing the isoquinolone derivatives in moderate to good yields. This strategy employing inexpensive...

Aldol condensation reaction is a very important class of industrially catalyzed reactions for the synthesis high‐value fine chemicals. Traditionally, usually carried out under alkaline conditions, but traditional liquid alkali catalysts may have problems such as separation and recovery difficulties catalyst side reactions. Therefore, solid base received much attention research in recent years. In this study, magnesium aluminum hydrotalcites were synthesized from chloride hexahydrate,...

The pyrido[2,3‐d]‐pyrimidin‐7‐one template is a crucial molecular fragment in antineoplastic drug palbociclib. Considering the importance of template, herein, we report simple and environmentally friendly electrocatalytic amination pyrido[2,3‐d]pyrimidin‐7‐ones with N,N‐dialkyl formamides as amine source NaBr electrolyte. This straightforward operationally protocol opens green efficient strategy for synthesis palbociclib derivatives moderate to good yields.

Herein, we report a simple and mild protocol for the chemoselective mono- diamination of ketone using pyrazole as amine source in combined copper-organocatalyst system. Various substrates are compatible, providing corresponding products moderate to good yields. This strategy gives an efficient convenient solution synthesis α-pyrazole α,α-dipyrazole derivatives. The control experiment demonstrates that situ generated hydrazone is key intermediate transformation.