A5100426083- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Synthesis and Biological Evaluation
- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- Oxidative Organic Chemistry Reactions
- Fluorine in Organic Chemistry
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Asymmetric Synthesis and Catalysis
- Glycosylation and Glycoproteins Research
- Synthesis and Catalytic Reactions
- Cyclopropane Reaction Mechanisms
- Chemical Synthesis and Reactions
- Click Chemistry and Applications
- Catalytic Processes in Materials Science
- Synthesis and biological activity
- Catalysis and Oxidation Reactions
- Asymmetric Hydrogenation and Catalysis
- Multicomponent Synthesis of Heterocycles
- Catalytic Cross-Coupling Reactions
- Enzyme Catalysis and Immobilization
- Synthesis of Organic Compounds
- Quinazolinone synthesis and applications
Hangzhou Normal University
2016-2025
Nanjing Tech University
2024
Shenzhen Institutes of Advanced Technology
2024
The Synergetic Innovation Center for Advanced Materials
2024
Northeast Agricultural University
2023-2024
Tianjin University
2024
Shanghai Institute of Materia Medica
2024
Chinese Academy of Sciences
2024
China University of Petroleum, Beijing
2022
Collaborative Innovation Center of Chemistry for Energy Materials
2022
This study describes a green and novel multi-component reaction for direct perfluoroalkylation/heteroarylation of [1.1.1]propellane with heteroarenes perfluoroalkyl iodines to diverse bicyclo[1.1.1]pentanes (BCPs).
Switchable multicomponent reactions have been attractive tools for the construction of compound libraries with skeleton diversity and complexity by slightly changing reaction conditions. Described herein is a regioselectivity-switchable formal [1 + 2 2] cycloaddition from difluoroalkyl compounds, enaminones, RNHNH2, ultimately using 1-methylindazol-3-amine as traceless mediator to switch inherent regioselectivity 1,3,4-trisubstituted pyrazole formation 1,4,5-trisubstituted pyrazoles....
Synthesis of bicyclo[1.1.1]pentane (BCP) heteroaryls continues to be a part the most important tasks in organic synthesis because they are significant class bioisosteres with universal applications drug discovery. However, substrate scope current multicomponent reactions is limited tertiary alkyl radicals and prefunctionalized (het)arenes due their intrinsic mechanisms, resulting decrease application value. Herein, we report straightforward alternative for (halo)alkyl BCP-heteroaryls from...
This study describes a green and sustainable photoinduced strategy for decarboxylative C–H (amino)alkylation of heteroarenes with carboxylic acids under metal- photosensitizer-free conditions.
In this study, a novel approach that combines photoinduced electron transfer (ET) with hydrogen atom (HAT) has been introduced for the selective β-C(sp3)–H pyridination of carbonyl compounds. This method is notable its absence transition metals and ability to function under benign reaction conditions, resulting in range pyridinated derivatives consistently moderate good yields. The significance technique further underscored by potential late-stage functionalization pharmaceutically...
Achieving site selectivity in carbon-hydrogen (C-H) functionalization reactions is a formidable challenge organic chemistry. Herein, we report novel approach to activating remote C-H bonds at the C5 position of 8-aminoquinoline through copper-catalyzed sulfonylation under mild conditions. Our strategy shows high conversion efficiency, broad substrate scope, and good toleration with different functional groups. Furthermore, our mechanistic investigations suggest that single-electron-transfer...
The first example of oxidative C–H fluoroalkoxylation quinoxalinones with fluoroalkyl alcohols under transition-metal and solvent-free conditions is described. This approach provides the synthesis fluoroalkoxylated quinoxaline derivatives good to excellent yields mild reactions conditions. method can also be extended facile efficient histamine-4 receptor.
A simple and mild protocol for copper catalyzed halogenation of quinoline at C5 C7 positions was developed, affording the desired remote C–H activation products in moderate to good yields.
The first example of nickel(II)-catalyzed site-selective C-H bond trifluoromethylation arylamine in water is established. In this transformation, a coordinating activation strategy performed by the utilization picolinamide as directing group, and target products are obtained moderate to good yields. addition, catalyst-in-water system can be reutilized eight times with slight loss catalytic activity applied green, concise synthesis acid red 266. Furthermore, series control experiments verify...
Abstract The first example of rapidly three‐component cascade reaction quinoxalinones with unactivated alkenes and TMSN 3 under mild condition has been described. This approach provides a practical solution for the rapid modification enables new planning strategies synthesis bioactive organoazides. A radical mechanism is responsible this transformation. magnified image
Herein, a novel method for the gram-scale synthesis of (E)-quinoxalinone oximes through multicomponent reaction under mild conditions is described. Such transformation was performed transition-metal-free conditions, affording (E)-oximes in moderate-to-good yield recrystallization. Our methodology demonstrates successful combination Mannich-type and radical coupling, providing green practical approach potentially bioactive quinoxalinone-containing molecules.
Bicyclo[1.1.1]pentane (BCP) heteroaryls make up an important class of BCP derivatives in drug discovery. Herein, we report the visible-light-mediated synthesis cyanoisopropyl BCP-heteroaryls motifs from
This study describes an efficient and green approach for the synthesis of potentially bioactive pyrrolo[1,2- a ]quinoxalin-4(5 H )-ones with appreciable functional group tolerance wide substrate scope.
Herein, we introduce an efficient and straightforward strategy for the selective C-H esterification alkylation of quinoxalin-2(1H)-ones with aldehydes. A key feature our study is ability to perform both using different types The reaction system highly compatible a range aldehydes, yielding C3-esterified C3-alkylated products in moderate-to-good yields. applicability this approach further enhanced by its scalability through continuous-flow synthesis, late-stage modification significant...
A novel <sc>d</sc>-glucosamine-derived pyridyl-triazole@palladium catalyst for solvent-free Mizoroki–Heck reactions and the synthesis of Axitinib is reported.
We report a Minisci-type cross-dehydrogenative alkylation in an aerobic atmosphere using abundant and inexpensive cerium chloride as photocatalyst air oxidant. This photoreaction exhibits excellent tolerance to functional groups is suitable for both heteroarene alkane substrates under mild conditions, generating the corresponding products moderate-to-good yields. Our method provides alternative approach late-stage functionalization of valuable substrates.
Herein, a novel and green multicomponent transformation for the α-bifunctionalization of methyl ketones enabled by heterogeneous catalysis solar photocatalysis has been described. This reaction is performed in water under an air atmosphere, affording corresponding products moderate-to-good yield. Our shows successful combination photocatalysis, giving sustainable practical alternative modification ketone derivatives.
The first example of a photoinduced rapid multicomponent cascade reaction aryldiazonium salts with unactivated alkenes and trimethylsilyl azide (TMSN3) under oxidant-free conditions is described. This approach provides the synthetic route for wide range unsymmetric azo compounds. compounds are obtained in good to excellent yields mild conditions. transformation applicable various alkenes, providing an alternative synthesis control experiment demonstrates that mechanism follows radical pathway.
Manipulating the super-assembly of polymeric building blocks still remains a great challenge due to their thermodynamic instability. Here, we report on type three-dimensional hierarchical core-satellite SiO2@monomicelle spherical superstructures via previously unexplored monomicelle interfacial route. Notably, in this superstructure, an ultrathin single layer subunits (~18 nm) appears typically hexagon-like regular discontinuous distribution (adjacent micelle distance ~30 solid interfaces...