A5054541116- Bat Biology and Ecology Studies
- Chemical Synthesis and Analysis
- Traumatic Brain Injury and Neurovascular Disturbances
- Amino Acid Enzymes and Metabolism
- Effects of Environmental Stressors on Livestock
- Wildlife Ecology and Conservation
- Porphyrin Metabolism and Disorders
- DNA and Nucleic Acid Chemistry
- Viral Infections and Vectors
- Physiological and biochemical adaptations
- Metabolism and Genetic Disorders
- Polyamine Metabolism and Applications
- Respiratory Support and Mechanisms
- RNA and protein synthesis mechanisms
- Folate and B Vitamins Research
- Neurosurgical Procedures and Complications
- Marine animal studies overview
- Enzyme function and inhibition
- Enzyme Structure and Function
- Biochemical and Molecular Research
- Fish Ecology and Management Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Enzyme Catalysis and Immobilization
- Cholinesterase and Neurodegenerative Diseases
- Asymmetric Synthesis and Catalysis
University of the West of Scotland
2021-2024
Loma Linda University
2024
University of Tennessee Health Science Center
1989-2023
Charles Sturt University
2018-2021
University of Winnipeg
2011-2018
Universität Hamburg
2016-2018
University of Manitoba
2018
University of New England
2007-2016
Memorial Hospital
2016
University of Leeds
1957-2013
White-nose syndrome (WNS) is an emerging disease of hibernating bats associated with cutaneous infection by the fungus Geomyces destructans ( Gd ), and responsible for devastating declines bat populations in eastern North America. Affected appear emaciated one hypothesis that they spend too much time out torpor during hibernation, depleting vital fat reserves required to survive winter. The has also been found at low levels on throughout Europe but without mass mortality. This finding...
Polyamide dimers containing three types of aromatic rings—pyrrole, imidazole, and hydroxypyrrole—afford a small-molecule recognition code that discriminates among all four Watson-Crick base pairs in the minor groove. The crystal structure specific polyamide dimer-DNA complex establishes structural basis for distinguishing T·A from A·T pairs. Specificity pair is achieved by means distinct hydrogen bonds between substituted pyrroles on ligand O2 thymine N3 adenine. In addition, shape-selective...
The unprecedented application of unmodified aldehydes as nucleophilic donors in direct catalytic asymmetric Mannich-type reactions is disclosed a full account. Our efforts broadening the applicability chiral pyrrolidine-based catalysts led to highly diastereo- and enantioselective concise synthesis functionalized α- β-amino acids, β-lactams, amino alcohols.
White-nose syndrome is devastating North American bat populations but we lack basic information on disease mechanisms. Altered blood physiology owing to epidermal invasion by the fungal pathogen Geomyces destructans (Gd) has been hypothesized as a cause of disrupted torpor patterns affected hibernating bats, leading mortality. Here, present data electrolyte concentration, haematology and acid-base balance little brown Myotis lucifugus, following experimental inoculation with Gd. Compared...
Polyamides containing N-methylimidazole (Im) and N-methylpyrrole (Py) amino acids are synthetic ligands that have an affinity specificity for DNA comparable to those of many naturally occurring binding proteins. A machine-assisted Fmoc solid phase synthesis polyamides has been optimized afford high stepwise coupling yields (>99%). Two monomer building blocks, Fmoc-Py acid Fmoc-Im acid, were prepared in multigram scale. Cleavage by aminolysis followed HPLC purification affords up 200 mg...
Selective placement of an aliphatic β-alanine (β) residue paired side-by-side with either a pyrrole (Py) or imidazole (Im) aromatic amino acid is found to compensate for sequence composition effects recognition the minor groove DNA by hairpin pyrrole−imidazole polyamides. A series polyamides were prepared which contain and acids, as well γ-aminobutyric (γ) "turn" "spring" residues. The binding affinities specificities these are regulated β/β, Py/β, Im/β Quantitative footprint titrations...
An 85-year-old, nondiabetic man is described with necrotizing (malignant) otitis externa. The patient developed facial nerve paralysis in the presence of a progressive cellulitis and chondritis external auditory meatus. Destruction bony meatus mastoid obliteration normal soft-tissue planes at skull base were documented by computed tomographic scans. Aspergillus fumigatus was isolated from deep tissue specimens. Fungal invasion bone soft confirmed histopathologically. Pseudomonas aeruginosa...
Spillover of viruses from bats to other animals may be associated with increased contact between them, as well shedding by bats. Here, we tested the prediction that little brown (Myotis lucifugus) co-infected M. lucifugus coronavirus (Myl-CoV) and Pseudogymnoascus destructans (Pd), fungus causes bat white-nose syndrome (WNS), exhibit different disease severity, viral molecular responses than infected only Myl-CoV or P. destructans. We took advantage natural persistence in were experimentally...
Bats are important reservoir hosts for emerging viruses, including coronaviruses that cause diseases in people. Although there have been several studies on the pathogenesis of humans and surrogate animals, is little information interactions these viruses with their natural bat hosts. We detected a coronavirus intestines 53/174 hibernating brown bats (Myotis lucifugus), as well lungs some individuals. Interestingly, presence virus was not accompanied by overt inflammation. Viral RNA amplified...
Aldolase antibody 38C2-catalyzed resolutions of tertiary aldols were studied. Tertiary proved to be very good substrates for catalyzed retro-aldol reactions. The catalytic proficiency, (kcat/KM)/kuncat, the these reactions was on order 1010 M-1. A fluorogenic aldol allowed quantitative study enantiomeric excess as a function reaction conversion, revealing an E value ca. 160 in this case. Study variety demonstrated that antibody-catalyzed retro-aldolization provides rapid entry highly...