A5037261221- Growth Hormone and Insulin-like Growth Factors
- Cancer, Hypoxia, and Metabolism
- Glycosylation and Glycoproteins Research
- Metabolism, Diabetes, and Cancer
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Screening and Detection
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Infant Nutrition and Health
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
- Protein Hydrolysis and Bioactive Peptides
- Acute Lymphoblastic Leukemia research
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Gene expression and cancer classification
- Protein Degradation and Inhibitors
- Milk Quality and Mastitis in Dairy Cows
- Gastric Cancer Management and Outcomes
- Bone and Dental Protein Studies
- Cancer Research and Treatments
- Protease and Inhibitor Mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
- Renal and related cancers
- Acute Kidney Injury Research
Commonwealth Scientific and Industrial Research Organisation
1999-2024
CSIRO Health and Biosecurity
2015-2024
The University of Adelaide
2009
Cooperative Research Centre for Tissue Growth and Repair
1999-2006
Health Sciences and Nutrition
1999
The majority of colorectal cancer (CRC) cases are preventable by early detection and removal precancerous polyps. Even though CRC is the second most common internal in Australia, only 30 per cent population considered to have risk factors participate stool-based test screening programs. Evidence indicates a robust, blood-based, diagnostic assay would increase compliance. A number potential blood-based protein biomarkers for been reported, but all lack sensitivity or specificity use as...
Elevated expression of insulin-like growth factor-II (IGF-II) is frequently observed in a variety human malignancies, including breast, colon, and liver cancer. As IGF-II can deliver mitogenic signal through both IGF-IR an alternately spliced form the insulin receptor (IR-A), neutralizing biological activity this factor directly potential alternative option to IGF-IR-directed agents. Using Fab-displaying phage library biotinylated precursor (1-104 amino acids) as target, we isolated Fabs...
To determine the usefulness of brain-derived neurotrophic factor (BDNF) as a diagnostic biomarker for colorectal cancer (CRC).ELISA immunoassay was used to examine BDNF concentrations in sera two different retrospective cohorts consisting CRC patients and age/gender matched controls. Cohort 1 consisted 99 controls 97 patients, whereas cohort 2 47 91 patients.In 1, median concentration significantly (p< 0.0001) lower patient samples (18.8 ng/mL, range 4.0-56.5 ng/mL) than control (23.4...
Betacellulin (BTC), a member of the epidermal growth factor (EGF) family peptide factors, was purified from growth-factor-enriched whey fraction bovine milk by combination ion-exchange chromatography, gel-filtration affinity chromatography and reverse-phase HPLC. Bovine BTC (bBTC) had an apparent molecular mass 21-22 kDa on SDS/PAGE exists in glycosylated form. The cDNA encoding bBTC obtained 5' 3' rapid amplification ends ('RACE'). primary translation product consists 178 amino acid...
Butyrate, a fermentation product of the large bowel microflora, is potentially protective against development colorectal cancer. In vitro, butyrate has been shown to induce apoptosis and inhibit proliferation in numerous cancer cell lines, including Although these tumor suppressing properties are well-documented experimental systems, mechanisms underlying induction effects not fully understood. Understanding cells, as well pathways involved cell's ability overcome them progress toward...
Background: Lipocalin 2 has been implicated in colorectal tumorigenesis but its usefulness as a diagnostic marker for the disease previously never determined. Methods: We have used ELISA immunoassay to measure level of serum lipocalin
Betacellulin (BTC), a member of the epidermal growth factor (EGF) family peptide factors, was purified from growth-factor-enriched whey fraction bovine milk by combination ion-exchange chromatography, gel-filtration affinity chromatography and reverse-phase HPLC. Bovine BTC (bBTC) had an apparent molecular mass 21-22 kDa on SDS/PAGE exists in glycosylated form. The cDNA encoding bBTC obtained 5ʹ 3ʹ rapid amplification ends (‘RACE’). primary translation product consists 178 amino acid...
Despite improvements in participation population-based screening programs, colorectal cancer remains a major cause of cancer-related mortality worldwide. Targeted interventions are desirable to reduce the health and economic burden this disease. Two-dimensional monolayers cell lines represent traditional vitro models for disease often used diverse purposes, including delineation molecular pathways associated with aetiology or gauge drug efficacy. The lack complexity such models, chiefly...
Abstract Colorectal cancer is one of the most commonly diagnosed cancers worldwide and its prevalence can be reduced by changes to lifestyle diet. Fermentation dietary fibre gut microbiota formation short chain fatty acids, in particular butyrate, widely thought play a role preventing development disease. Despite butyrate’s known pro-apoptotic effects, subpopulation cells able overcome these anti-neoplastic effects colonic luminal butyrate proliferate establish tumours vivo. In this study,...
Abstract Worldwide, colorectal cancer (CRC) is the third most common and second leading cause of death, with an annual incidence in 2012 1.4 million CRC cases mortality around 700,000 [1]. Fortunately majority are preventable by early detection removal colonoscopy or surgery. Currently Australia, only widely used non-invasive screening test for immunological faecal occult blood (iFOBT), which has been shown to reduce 15-25% [2]. There however significant issues that limit its effectiveness...
Abstract Colorectal cancer (CRC) is the second most common internal in Australia and leading cause of death with &gt; 4,400 deaths 2007 [1]. Currently there are greater than 14,000 newly diagnosed cases annually direct costs over $2 billion per annum Worldwide, an annual incidence almost a million CRC mortality around 600,000 [2]. Unfortunately, 30-50% patients have occult or overt metastases at presentation once tumours metastasised prognosis very poor five year survival less 10% [3]....
<div>Abstract<p>Elevated expression of insulin-like growth factor-II (IGF-II) is frequently observed in a variety human malignancies, including breast, colon, and liver cancer. As IGF-II can deliver mitogenic signal through both IGF-IR an alternately spliced form the insulin receptor (IR-A), neutralizing biological activity this factor directly potential alternative option to IGF-IR–directed agents. Using Fab-displaying phage library biotinylated precursor (1–104 amino acids) as...
<div>Abstract<p>Elevated expression of insulin-like growth factor-II (IGF-II) is frequently observed in a variety human malignancies, including breast, colon, and liver cancer. As IGF-II can deliver mitogenic signal through both IGF-IR an alternately spliced form the insulin receptor (IR-A), neutralizing biological activity this factor directly potential alternative option to IGF-IR–directed agents. Using Fab-displaying phage library biotinylated precursor (1–104 amino acids) as...