A5005513857- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Economic and Financial Impacts of Cancer
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Bladder and Urothelial Cancer Treatments
- Genetic factors in colorectal cancer
- Mathematical Biology Tumor Growth
- Trauma and Emergency Care Studies
- Pancreatic and Hepatic Oncology Research
- COVID-19 and healthcare impacts
- Health Systems, Economic Evaluations, Quality of Life
- Colorectal and Anal Carcinomas
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Immunotherapy and Immune Responses
- HIV/AIDS Research and Interventions
- Nuts composition and effects
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- HIV/AIDS Impact and Responses
Poudre Valley Hospital
2023
Royal Adelaide Hospital
1997-2021
NHS England
2020
University of Colorado Health
2020
The University of Adelaide
2016-2017
Colorectal Surgical Associates
2015
South Australia Pathology
2014
Harvey Mudd College
2008
One of the most challenging tasks in constructing a mathematical model cancer treatment is calculation biological parameters from empirical data. This task becomes increasingly difficult if involves several cell populations and modalities. A sophisticated constructed by de Pillis et al. , Mixed immunotherapy chemotherapy tumours: Modelling, applications interpretations J. Theor. Biol. 238 (2006), pp. 841–862; tumour cells, specific non‐specific immune cells (natural killer (NK) CD8 + T other...
Objectives: There is emerging data supporting rapid triage of low-risk chest pain patients to help facilitate Emergency Department (ED) throughput. We assessed an algorithm for accelerated rule-out acute coronary syndrome in with undetectable initial high sensitivity cardiac troponin (hs-cTn assays; Roche Diagnostics) a real-world clinical setting. Methods: All adults presenting chief complaint non-traumatic our tertiary care ED HEART score ≤3 at least one hs-cTn and EKG obtained were...
Abstract Aim The aim was to determine whether the addition of additional cycles chemotherapy during ‘wait period’ following neoadjuvant chemoradiotherapy for rectal cancer improves pathological complete response ( pCR ) rate. Method Rectal patients were randomly allocated either a standard 10 week wait period before surgery (standard chemoradiotherapy, SCRT or receive three fluorouracil based similar (extended XCRT ). primary end‐point as determined by blinded assessment. Results Forty‐nine...
Background: Registry data from four major public hospitals indicate trends in clinical care and survival colorectal cancer over three decades, 1980 to 2010. Materials Methods: Kaplan-Meier productlimit estimates Cox proportional hazards models were used investigate disease-specific multiple logistic regression analyses explore first-round treatment trends. Results: Five-year survivals increased 48% for 1980-1986 63% 2005-2010 diagnoses. Survival increases applied each ACPS stage (Australian...
Data from population-based registries have demonstrated a recent increase in case survival for colonic cancer which has been attributed to earlier diagnosis. The present study was performed identify time trends patients with single institution, and factors associated any such improvement.Data regarding 1264 who were diagnosed between January 1981 December 1995 obtained the Royal Adelaide Hospital Cancer Registry. Prognostic examined age, sex, Australian clinicopathologic stage (ACPS),...
Background: Registry data from four major public hospitals indicate trends over three decades 1980 to 2010 in treatment and survival colorectal cancer with distant metastases at diagnosis (TNM stage IV). Materials Methods: Kaplan-Meier product-limit estimates Cox proportional hazards models for investigating disease-specific multiple logistic regression analyses indicating first-round trends. Results: Two-year survivals increased 10% 1980-84 35% 2005-10 diagnoses. Corresponding increases...
Abstract Background Two million non-emergency surgeries are being cancelled globally every week due to the COVID-19 pandemic, which will have a major impact on patients and healthcare systems. Objective To determine whether it is feasible safe continue surgery in pandemic Design, setting participants This cohort study of 500 consecutive undergoing dedicated cold site following first case that was reported institution. The carried out during peak United Kingdom, currently has one highest...
Purpose: Immune checkpoint inhibitor and VEGFR combinations are effective treatments for patients with metastatic renal cell carcinoma (mRCC). This phase I/II clinical trial evaluated the safety efficacy of pembrolizumab cabozantinib in mRCC. Experimental Design: Eligible had mRCC clear-cell or non-clear histology, adequate organ function, Eastern Cooperative Oncology Group 0–1 performance status, no prior exposure to cabozantinib. The primary endpoint was objective response rate (ORR) at...
Data from registries at four major public hospitals in South Australia indicate increased 5-year disease-specific survivals for colorectal cancer 48% to 63% between 1980–1986 and 2005–2010. For 80+ year olds, the increase was smaller, 47% 52%. Risk of case fatality halved overall, adjusting age, gender, stage, differentiation sub-site. Patients aged years had a lower risk reduction about third (hazards ratio: 0.69; 95% confidence limits, 0.52–0.92). Percentages having surgery other specified...
Abstract Prostate cancer patients (pts) with non-metastatic prostate specific antigen (PSA) progression after local therapy and a long PSA doubling time (PSADT) usually have period of observation prior to starting on androgen deprivation (ADT). We report results an investigator-initiated, IRB-approved Phase II clinical trial (CT.gov-NCT03087903) investigating grape seed extract (GSE) in pts PSA-only recurrence maximum for cancer. Pts baseline ≥ 0.2 ng/mL rising 2 separate occasions no...
Abstract Colorectal cancer (CRC) is the second most common internal in Australia and leading cause of death with > 4,400 deaths 2007 [1]. Currently there are greater than 14,000 newly diagnosed cases annually direct costs over $2 billion per annum Worldwide, an annual incidence almost a million CRC mortality around 600,000 [2]. Unfortunately, 30-50% patients have occult or overt metastases at presentation once tumours metastasised prognosis very poor five year survival less 10% [3]....
<p>TRAEs in ≥10% of patients and all grade ≥3</p>
<div>Purpose:<p>Immune checkpoint inhibitor and VEGFR combinations are effective treatments for patients with metastatic renal cell carcinoma (mRCC). This phase I/II clinical trial evaluated the safety efficacy of pembrolizumab cabozantinib in mRCC.</p>Experimental Design:<p>Eligible had mRCC clear-cell or non-clear histology, adequate organ function, Eastern Cooperative Oncology Group 0–1 performance status, no prior exposure to cabozantinib. The primary endpoint was...
<p>CONSORT diagram and patient disposition. DLT, dose-limiting toxicity; RP2D, recommended phase II dose; P, pembrolizumab; C, cabozantinib.</p>