A5071953803- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Economic and Financial Impacts of Cancer
- Multiple Myeloma Research and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Protein Degradation and Inhibitors
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Bladder and Urothelial Cancer Treatments
- Cancer Treatment and Pharmacology
- Lung Cancer Research Studies
- Neonatal and fetal brain pathology
- Ferroptosis and cancer prognosis
- Mosquito-borne diseases and control
- Pharmaceutical Economics and Policy
- Pancreatic and Hepatic Oncology Research
- Hematological disorders and diagnostics
- Peptidase Inhibition and Analysis
- Child Nutrition and Water Access
- Infectious Diseases and Tuberculosis
- Brain Metastases and Treatment
- Corneal surgery and disorders
- Lung Cancer Treatments and Mutations
- Curcumin's Biomedical Applications
Era's Lucknow Medical College and Hospital
2016-2024
United States Food and Drug Administration
2024
MetroHealth
2023-2024
Memorial Hospital
2021-2023
University of Colorado Health
2021-2023
MetroHealth Medical Center
2023
Case Western Reserve University
2023
Mayo Clinic
2013-2014
WinnMed
2011-2014
ICARE Eye Hospital & Postgraduate Institute
2014
Identification of men harbouring insignificant prostate cancer (PC) is important in selecting patients for active surveillance. Tools have been developed PSA-screened populations to identify such based on clinical and biopsy parameters.Prospectively collected case series 848 was treated with radical prostatectomy between July 2007 October 2011 at an English tertiary care centre. Tumour volume assessed by pathological examination. For each tool, receiver operator characteristics were...
The Oncotype DX colon cancer assay is a clinically validated predictor of recurrence risk in stage II patients. This prospective study evaluated the impact score (RS) results on physician recommendations regarding adjuvant chemotherapy T3, mismatch repair-proficient (MMR-P) Patients and Methods. Stage IIA patients were enrolled 17 centers. Patient tumor specimens assessed by RS test (quantitative reverse transcription-polymerase chain reaction) repair (immunohistochemistry). For each...
Prior economic analysis that compared the 12-gene assay to published patterns of care predicted would improve outcomes while lowering medical costs for stage II, T3, mismatch-repair-proficient (MMR-P) colon cancer patients. This study assessed validity those findings with real-world adjuvant chemotherapy (aCT) recommendations from US third-party payer perspective.
Background: Lymphadenopathy is a common presenting symptom in various diseases. Objective: The present study was undertaken to evaluate the usefulness of fine-needle aspiration cytology (FNAC) as diagnostic tool cases lymphadenopathy, find frequency and cause lymph node enlargement patients different age groups analyze cytomorphological patterns associated with lymphadenopathies. Materials Methods: conducted department pathology, Shri M.P. Shah Medical College, Jamnagar from June 2008 July...
We aimed to study the pattern of liver-injury in children with dengue fever (DF) and validate serum aminotransferase ≥1,000 IU/L as a marker severe DF.Children admitted DF were included. was defined by presence clinical criteria positive serological or antigen tests absence other etiology. severity graded without warning signs dengue. Liver-injury alanine (ALT) more than twice upper limit normal (boys, 30 IU/L; girls, 21 IU/L).Of 372 DF, 144 (38.7%) had liver-injury. Risk levels increased...
Background . We assessed the balance between number of publications required by medical teachers and publication space available in Indian journals. Methods The Medical Council India (MCI) website, its guidelines documents were searched we extracted data on colleges, undergraduate postgraduate seats faculty requirement. assistant professors associate was calculated. requirements estimated according to MCI’s February 2020 guidelines. A which satisfied above for promotion counted as ‘eligible...
Background: Ursodeoxycholic Acid (UDCA) is a bile acid widely used in the treatment of cholestatic liver disorders. Few studies have been conducted using UDCA indirect hyperbilirubinemia. We planned this study to know role on hyperbilirubinemia neonatesMethods: The was Department Paediatrics and Neonatology at Eras Lucknow Medical College Hospital from November 2015 September 2017 96 term neonates with total bilirubin levels phototherapy range. They were randomized into 3 Groups receiving...
Background: According to infant and child mortality in India, levels trends determinants the under 5 rates (UFMR) of India is facing a steady decline but at this rate could not meet its target millennium development goal-4 (MDG-4), which aimed reduced UFMR by 2/3rds between 1990 2015. Objective current study was complementary feeding practices amongst children age group 6 months 23 Lucknow.Methods: In prospective cross sectional 256 mothers were interviewed over period referral care centre...
4544 Background: Checkpoint inhibitors (CPI) and vascular endothelial growth factor receptor (VEGFi) are standard treatments for patients (pts) with mRCC. This phase I/II study evaluated the safety efficacy of novel combination pembrolizumab (pembro) cabozantinib (cabo). The I dose escalation data was presented at ASCO GU 2019. We now report objective response rate (ORR), progression free survival (PFS), overall (OS), toxicity in II expansion. Methods: Eligible pts had metastatic clear cell...
Purpose: Immune checkpoint inhibitor and VEGFR combinations are effective treatments for patients with metastatic renal cell carcinoma (mRCC). This phase I/II clinical trial evaluated the safety efficacy of pembrolizumab cabozantinib in mRCC. Experimental Design: Eligible had mRCC clear-cell or non-clear histology, adequate organ function, Eastern Cooperative Oncology Group 0–1 performance status, no prior exposure to cabozantinib. The primary endpoint was objective response rate (ORR) at...
3640 Background: Prior economic analysis of a 12-gene assay (Oncotype DX), compared with patterns care reported in the NCCN database patients stage II, T3, DNA mismatch repair proficient (MMR-P) colon cancer, predicted that would save medical costs and improve patient well-being (Hornberger et al. Value Health 2012). This study assessed validity those findings actual adjuvant chemotherapy (aCT) recommendations. Methods: Outcomes were estimated for MMR-P cancer using Markov model. A 141 from...
453 Background: A 12-gene assay (Oncotype DX Colon Cancer) has been clinically validated as a predictor of recurrence risk in stage 2 colon cancer patients following surgery. We conducted the first prospective study to characterize impact Recurrence Score results on medical oncologists’ recommendations regarding adjuvant chemotherapy T3, Mismatch Repair-proficient (MMR-P) patients. Methods: Consecutive with resected 2A who were candidates for consented and enrolled by 105 oncologists from 17...
There are no systematic data regarding nonmaintained induction for those patients with multiple myeloma (MM) who do not receive consolidative autologous stem cell transplantation. Of 173 newly diagnosed MM treated lenalidomide and dexamethasone (LenDex) as primary therapy, 31 had their discontinued reasons other than progression or alternate therapy. Median free survival (PFS) from the time of discontinuing was longer in received ≥ 1 year (39 vs. 13 months, P < 0.05); there difference PFS...
391 Background: Prior economic analysis of a 12-gene assay (Oncotype DX), compared with patterns care reported in the NCCN database patients stage II, T3, DNA mismatch repair proficient (MMR-P) colon cancer, predicted that would save medical costs and improve patient well-being (Hornberger et al., Value Health, 2012). This study assessed validity those findings actual adjuvant chemotherapy (aCT) recommendations. Methods: Outcomes were estimated for MMR-P cancer using Markov model. A 141 from...