A5037690393- Cardiac, Anesthesia and Surgical Outcomes
- Immune Cell Function and Interaction
- Cardiac Arrest and Resuscitation
- Forensic Entomology and Diptera Studies
- Intensive Care Unit Cognitive Disorders
- Transplantation: Methods and Outcomes
- Viral Infections and Immunology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Respiratory Support and Mechanisms
- Viral gastroenteritis research and epidemiology
- Escherichia coli research studies
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- IL-33, ST2, and ILC Pathways
- Calcium signaling and nucleotide metabolism
- Mollusks and Parasites Studies
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Cardiac Structural Anomalies and Repair
- Organ Transplantation Techniques and Outcomes
- Cellular transport and secretion
- Hematopoietic Stem Cell Transplantation
- Immunotherapy and Immune Responses
- Mechanical Circulatory Support Devices
- Acute Kidney Injury Research
Education & Research Foundation
2023-2025
University of Toronto
1989-2024
The University of Texas MD Anderson Cancer Center
2023-2024
University of California, San Diego
2014-2023
Sanford Consortium for Regenerative Medicine
2023
Santa Rosa Memorial Hospital
2022
Arrowhead Regional Medical Center
2022
Loma Linda University
2013-2022
Loma Linda University Medical Center
2013-2022
Kaiser Permanente Fontana Medical Center
2022
Although viral hepatocellular carcinoma (HCC) is declining, nonviral HCC, which often the end stage of nonalcoholic or alcoholic steatohepatitis (NASH, ASH), on an upward trajectory. Immune checkpoint inhibitors (ICIs) that block T cell inhibitory receptor PD-1 were approved for treatment all HCC types. However, only a minority patients show robust and sustained response to blockade, calling improved understanding factors negatively impact rate duration discovery new adjuvant treatments...
Wound care is a common problem in small animals. Antimicrobial resistance, biofilm, time constraints, and the cost of surgery or specialized dressings hinder efforts to deliver prompt wound healing. Maggot therapy has been very effective human equine care, but little research evaluated its safety efficacy dogs cats. This study was initiated evaluate utility, efficacy, maggot debridement for animal veterinary practice Mexico. Six cats four were treated with when their wounds failed respond...
Early-life LTβR signaling programs the mesenteric lymph node stromal cell environment, optimizing gut IgA responses in adult mouse.
Point mutations in leucine-rich repeat kinase 2 (LRRK2) cause Parkinson's disease and augment LRRK2's activity. However, cellular pathways that endogenously enhance LRRK2 function have not been identified. While overexpressed Rab29 draws to Golgi membranes increase activity, there is little evidence endogenous performs this under physiological conditions. Here, we identify Rab38 as a novel physiologic regulator of melanocytes. In mouse melanocytes, which express high levels Rab38, Rab32,...
Germ line C transcripts can be induced by IL-4 in the human B cell line, BL-2. Utilizing a IFN-gamma activation site-like DNA sequence element located upstream of I epsilon exon, we demonstrated gel mobility shift assays that binding activity cytosol and nucleus BL-2 cells. This factor was designated NAF (IL-4-induced nuclear-activating factors) identified as tyrosine phosphoprotein, which translocates from to upon treatment. Because these are characteristics signal transducer activator...
Intra-hospital transport (IHT) of intensive care unit (ICU) patients is associated with a 30% to 60% incidence adverse events (AEs). This prospective observational study collected data from 200 patient transports 24-bed cardiovascular between July 2017 and December 2017. Phase 1 the focused on identifying correcting deficiencies in nurses' knowledge regarding IHT. 2 observed occurrence type AEs during IHT ICU without physician accompaniment. The preeducation mean nursing score was 30.8 ±...
Autoantibodies directed against endogenous proteins including contractile and endothelial antigens are frequently detected in patients with heart failure after transplantation. There is evidence that these autoantibodies contribute to cardiac dysfunction correlate clinical outcomes. Currently, patient sera using individual ELISA assays (one for each antigen). Thus, screening many laborious consumes a large amount of sample. To better capture the broad-scale antibody reactivities occur...
Mitochondrial dysfunction plays an important role in the etiology of neurodegenerative diseases. However, progressive nature neuronal loss genetic models mitochondrial suggests presence compensatory mechanisms promoting survival under these conditions. Here, we identified energy metabolism kinase LKB1 as a key regulator activated neurons, following dysfunction. To accomplish this, have created vivo model based on deletion protein apoptosis-inducing factor (AIF) postmitotic neurons. Loss...
Fibrinogen-like protein 2 (FGL2) is an immunomodulatory that expressed by regulatory T cells (Tregs). The objective of this study was to determine if recombinant FGL2 (rFGL2) treatment or constitutive overexpression could promote transplant tolerance in mice. Although rFGL2 prevented rejection fully mismatched cardiac allografts, all grafts were rejected after stopping treatment. Next, we generated transgenic mice (fgl2(Tg) ) ubiquitously overexpressed FGL2. These developed normally and had...
Immunoglobulin (Ig) A supports mucosal immune homeostasis and host–microbiota interactions. While commensal bacteria are known for their ability to promote IgA, the role of non-bacterial microbes in induction IgA remains elusive. Here, we demonstrate that permanent colonization with protozoan Tritrichomonas musculis (T.mu) promotes T cell–dependent, class-switch recombination, intestinal accumulation IgA-secreting plasma cells (PC). T.mu specifically drives expansion follicular helper a...
Despite numerous studies and recommendations, the acceptance of treatments involving medicinal maggots in many clinics has been slow. Several factors may account for this, including gender nurses administering treatment, their level work experience, perceived personal stress. The aim study was to assess impact selected variables (gender, stress level) on readiness administer maggot debridement therapy (MDT), which is a form biodebridement. population cohort 290 wound care providing...
"Cardiac Arrest Due to Torsades De Pointes in a Patient with Complete Heart Block: The “R-On-T” Phenomenon." Baylor University Medical Center Proceedings, 23(4), pp. 361–362
The exposure of molecular signals for simian virus 40 (SV40) cell entry and nuclear has been postulated to involve calcium coordination at two sites on the capsid made Vp1. role calcium-binding site 2 in SV40 infection was examined by analyzing four single mutants 2, Glu160Lys, Glu160Arg, Glu157Lys (E157K), Glu157Arg mutants, an E157K-E330K combination mutant. last three were nonviable. All replicated viral DNA normally, all except produced particles containing proteins DNA. defect 1-site...
<h3>BACKGROUND:</h3> Unplanned postoperative intubation is an important event that may influence the outcome of thyroid- and parathyroidectomies. We performed a focused study on association preoperative functional status with unplanned outcomes in these relatively common surgeries. <h3>METHODS:</h3> Utilizing data from National Surgical Quality Improvement Program database 2007 to 2013, propensity score-matched retrospective cohort was assessing this functionally independent versus dependent...