Background: The emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in a worldwide devastating effect with diagnostic challenge. Identifying risk factors of severity aids assessment for the need early hospitalization. We aimed to demonstrate, first time, clinical, laboratory and radiological characteristics disease 2019 (COVID-19) patients, identify predictors describe antimicrobial resistance profile patients from Upper Egypt. Materials Methods: Demographic...

Successful antibiotic treatment of infections relies on accurate and rapid identification the infectious agents. Pseudomonas aeruginosa is implicated in a wide range human that mostly become complicated life threating, especially immunocompromised critically ill patients. Conventional microbiological methods take more than three days to obtain results. Pyocyanin distinctive electroactive biomarker for aeruginosa. Here, we have prepared polyaniline/gold nanoparticles decorated ITO electrode...

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Hepatitis E virus (HEV) is an emerging infectious agent that causes acute hepatitis in developing and developed countries. Diagnosis of HEV infection has not been routinely done Egyptian hospitals, clinicians do prescribe ribavirin (RBV) for cases unknown etiology (AHUE). We aimed to screen patients with AHUE the presence markers determine complications associated infection.HEV (anti-HEV IgM, anti-HEV IgG, RNA) were assessed (n=300) admitted Assiut University Hospitals. RT-qPCR was used...

Beta glucan (β-glucan) has promising bioactive properties. Consequently, the use of β-glucan as a food additive is favored with dual-purpose potential increasing fiber content products and enhancing their health Our aim was to evaluate biological activity (antimicrobial, antitoxic, immunostimulatory, anticancer) extracted from Saccharomyces cerevisiae using modified acid-base extraction method. The results demonstrated that method gives higher efficacy than in water Using 0.5 mg dry weight...

Abstract Pseudomonas aeruginosa is the most common pathogenic gram-negative bacteria causing corneal ulcers globally. In severe cases, often after trauma and eye injury, destruction progresses rapidly may be completed within 24–48 h blindness. our preliminary work, we have established an ultrasensitive polyaniline (PANI)/gold nanoparticles (Au NPs)/indium tin oxide (ITO) modified sensor for rapid detection of pyocyanin (PYO) in P . infections with a linear range from 238 μM to 1.9 limit 500...

Thiazoles, thiazolidinones and azetidinones are highly ranked amongst natural synthetic heterocyclic derivatives due to their great pharmaceutical potential.

Several outbreaks of acute hepatitis unknown etiology (AHUE) in children were reported 2022 many countries, with adenovirus identified as the etiological agent most them. We aimed to evaluate characteristics and outcomes AHUE cases Egypt.Hospitalized patients included study. Drug-induced, alcoholic hepatitis, autoimmune Wilson's disease either by medical history or routine laboratory diagnosis. Molecular serological approaches used investigate common viral causes such A-E viruses,...

Hepatitis E virus (HEV) infection is endemic in developing and developed countries. HEV was reported to be excreted the milk of ruminants, raising possibility transmission through ingestion contaminated milk. Therefore, detection markers samples becomes pivotal. However, includes inhibitory components that affect assays. Previously it dilution matrix improves performance molecular assay, however, not best strategy especially when sample has a low load. objective this study compare effect...

Nowadays, the growth of drug-resistant microbial strains (MDRs) is a serious public health threat worldwide. Moreover, tens millions people are annually diagnosed with cancer worldwide, and more than half patients ultimately die. In present study, new series 2-(4-substituted-thiazol-2-ylamino)acetamides N-(4-substituted-thiazol-2-yl)acetamides incorporating sulfonamide moieties were designed, synthesized, well-characterized successfully evaluated for their antimicrobial activity against...

Viruses can trigger glomerulonephritis (GN) development. Hepatitis viruses, especially C virus and B are examples of the viruses that GN initiation or progression. However, proof a correlation between E infection is not clear. Some studies confirmed development during acute chronic HEV infections, mainly caused by genotype 3. While others reported there no relation exposure A recent study showed reduced glomerular filtration rate was developed in 16% 1 (HEV-1) infections returned to normal...

Hepatitis A virus (HAV) and E (HEV) are transmitted through the fecal-oral route. HAV outbreaks one HEV outbreak have been reported in Egypt. However, impact of HAV-HEV co-infection is not known. In this study, we assessed markers acute HAV-infected patients (n = 57) enrolled Assiut University hospitals. We found that 36.8% were also positive for (anti-HEV IgM RNA), while 63.2% mono-infected. Demographic clinical criteria comparable both mono-infected co-infected patients. Although liver...

Chloroacylation of 3-amino-2-phenylpyrazole-4-carboxamide (2) using chloroacetyl-(propionyl) chloride affording 6-chloromethyl(ethyl)-1-phenylpyrazolo[3,4-d]pyrimidin-4[5H]-one (3) or (6). Chlorine atom in compound (6) underwent nucleophilic substitution reaction with primary secondary amines to give 6-alkyl(aryl)aminomethyl(ethyl)-1-phenylpyrazolo[3,4-d]pyrimidin-4[5H]-one (4a-g,7a-f). When arylaminomethyl( ethyl)pyrazolopyrimidine was treated formaline (30%) solution ethanol, Mannich...

Impaired renal functions have been reported with Hepatitis E virus (HEV) infections, especially genotypes 3 and 4. These complications were during the acute chronic phases of infection. HEV genotype 1 causes infection, effect HEV-1 infections on is not known. We examined kidney function parameters in serum patients (AHE, n = 31) phase All included developed an self-limiting course without progression to fulminant hepatic failure. compared demographic, laboratory, clinical data between AHE...

Abstract Successful antibiotic treatment of infections relies on accurate and rapid identification the infectious agents. Pseudomonas aeruginosa is implicated in a wide range human that almost complicated become life threating especially immunocompromised critically ill patients. Conventional microbiological methods take more than 3 days to obtain results. Pyocyanin distinctive electroactive biomarker for . Here, we have developed diagnostic (polyaniline) PANI gold nanoparticles (Au NPs)...

Background: The Coronavirus pandemic is the most significant global health crisis of our era. Since it first appeared in late 2019, virus has spread to every continent. Furthermore, systemic inflammation a common feature many autoimmune diseases, increasing risk cardiovascular and thromboembolic which have also been linked COVID-19. Objectives: This study aimed identify expression IL-17 TGF-β as predictors COVID-19 severity patients with without disease. Additionally, sought investigate role...

Background: COVID-19 is a respiratory viral disease caused by the severe acute syndrome-Coronavirus type 2 (SARS-CoV-2). The World Health Organization (WHO) declared SARS-CoV-2 infection as well global health emergency. vaccines provide strong protection against serious illness, hospitalization, and death. Objectives: This study aimed to assess correlation between vaccine [type, doses] load, oxygen saturation, inflammatory markers, severity, morbidity among Egyptian inpatients at Assiut...

Background and study aim: A debate exists regarding the optimum timing of corticosteroid initiation in acute hepatitis-induced liver failure particularly non-A-E hepatitis. We aimed to evaluate therapeutic efficacy early Patients Methods: In this retrospective study, records patients Al-Rajhy Liver University Hospital with hepatitis were assessed between 2019-2022. Clinical, laboratory, mortality data evaluated for patients. function model end-stage disease (MELD) score corticosteroids group...

Abstract Background Ventilator-associated pneumonia (VAP) due to drug resistant Acinetobacter baumannii ( A. ) is a challenging nosocomial problem associated with increased morbidity and risk of mortality. Objective This study aimed investigate plasmid mediated quinolone resistance genes (PMQR) as mechanism transmission, factors outcome VAP. Methods prospective cohort included 100 VAP patients between October 2020 December 2022. Microbiological confirmation . was done PMQR were exposed by...