A5076427944- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Glycosylation and Glycoproteins Research
- Rheumatoid Arthritis Research and Therapies
- Topological Materials and Phenomena
- Lipid Membrane Structure and Behavior
- Protein purification and stability
- Bone and Joint Diseases
- Hip and Femur Fractures
- Polyoxometalates: Synthesis and Applications
- Musculoskeletal synovial abnormalities and treatments
- Chemical synthesis and alkaloids
- Chemical Synthesis and Characterization
- Spine and Intervertebral Disc Pathology
- Astro and Planetary Science
- Natural product bioactivities and synthesis
- Systemic Lupus Erythematosus Research
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Condensed Matter Physics
- Hip disorders and treatments
- Autoimmune and Inflammatory Disorders Research
- Case Reports on Hematomas
- Phase-change materials and chalcogenides
- Medicinal plant effects and applications
Hiroshima University
2024-2025
Kyoto University
2001-2022
Kyoto University Institute for Chemical Research
2020-2022
Gifu University
2022
Kyoto Bunkyo University
2020-2021
Japan Aerospace Exploration Agency
2012-2021
Takayama Red Cross Hospital
2020
Sendai Kousei Hospital
2012-2013
Wakayama University
2013
Matsunami General Hospital
2013
Using angle-resolved photoemission spectroscopy (ARPES) and density functional theory (DFT), an experimental theoretical study of changes in the electronic structure (dispersion dependencies) corresponding modification energy band gap at Dirac point (DP) for topological insulator (TI) $$\textrm{Mn}_{1-x} \textrm{Ge}_x \textrm{Bi}_2 \textrm{Te}_4$$ have been carried out with gradual replacement magnetic Mn atoms by non-magnetic Ge when concentration latter was varied from 10% to 75%. It shown...
A totally nonempirical relativistic cluster calculation of transition-metal ${L}_{2,3}$-edge x-ray-absorption near-edge structure including configuration interaction has been performed. remarkable predictive power this demonstrated for three contrasting materials with different d-electron numbers and coordination $({\mathrm{SrTiO}}_{3},$ NiO, ${\mathrm{CaF}}_{2})$ by excellent reproduction both the absolute peak energies their relative intensities without any empirical parameters.
Abstract Endocytic pathways are practical routes for the intracellular delivery of biomacromolecules. Along with this, effective strategies endosomal cargo release into cytosol desired to achieve successful delivery. Focusing on compositional differences between cell and membranes pH decrease within endosomes, we designed lipid‐sensitive pH‐responsive endosome‐lytic peptide HAad. This contains aminoadipic acid (Aad) residues, which serve as a safety catch preferential permeabilization over...
Abstract Fc region binding peptide conjugated with attenuated cationic amphiphilic lytic L17E trimer [FcB(L17E) 3 ] was designed for immunoglobulin G (IgG) delivery into cells. Particle‐like liquid droplets were generated by mixing Alexa Fluor 488 labeled IgG (Alexa488‐IgG) FcB(L17E) . Droplet contact the cellular membrane led to spontaneous influx and distribution of Alexa488‐IgG throughout cells in serum containing medium. Involvement machinery accompanied actin polymerization ruffling...
In vivo measurement of lumbar foramen using computed tomography and an axial loading device in healthy young subjects.To investigate the effects on morphology vivo.In vitro studies have shown morphologic changes response to loading. The foraminal dimensions vivo, however, are poorly understood.The study population consisted 12 asymptomatic volunteers [6 men 6 women; age range, 22-34 y (mean, 27 y)]. Lumbar images were compared with without a compression (DynaWell), differences disk height...
A delay in establishing the diagnosis of an occult fracture hip that remains unrecognised after plain radiography can result more complex treatment such as arthroplasty being required. This might be avoided by earlier using MRI. The aim this study was to investigate best MR imaging sequence for diagnosing fractures. From a consecutive cohort 771 patients admitted between 2003 and 2011 with clinically suspected hip, we retrospectively reviewed MRI scans 35 who had no evidence on their...
As the first non-peptide endothelin receptor antagonist from a higher plant, new triterpenoid, myriceric acid A (50-235) (1) was isolated bayberry, Myrica cerifera. Myriceric inhibited not only an endothelin-1-induced increase in cytosolic free Ca2+ concentration (IC50 = 11 +/- 2 nM) but [125I]endothelin-1 binding rat aortic smooth muscle cells (Ki 66 15 nM). Two related triterpenoids, C (6), and D (8), were also isolated. Furthermore, chemical modification of these natural products led to...
A retrospective study of 58 patients undergoing cantilever transforaminal lumbar interbody fusion (c-TLIF).To evaluate morphologic changes in the intervertebral foramen (IVF) on side contralateral to spacer insertion c-TLIF using plain x-ray films and computed tomography scan.The unilateral spacers have not been well studied.Fifty-eight consecutive with dysplastic or degenerative disk diseases underwent 96 kidney-type local bone grafts. Radiographic findings (sagittal angle), scan (coronal...
Four new metabolites (1-4) were isolated from mycelium of Aspergillus terreus IFO 6123 producing asterriquinone (ARQ). The structures 1 and 2 shown to be 3, 6-bis[1-(1, 1-dimethyl-2-propenyl)-1H-indol-3-yl]-furo[3, 2-b]furan-2, 5-dione (asterridinone) 2, 5-bis[1-(1, 1-dimethyl-2-propenyl)-1H-indol-3-yl]-3-acetoxy-6-hydroxy-2, 5-cyclohexadiene-1, 4-dione (ARQ monoacetate), respectively, by the chemical spectral data. Compounds 3 4 identified with known isomers, 2-[(1,...
Although tight control of rheumatoid arthritis (RA) has been achieved through the development effective medication, surgical intervention is still required for a certain subpopulation patients. To examine systemic effects orthopaedic surgery, we evaluated improvements in disease activity, daily function, and medication after surgery.A prospective cohort study was conducted 196 cases elective surgery 150 patients with RA from January 2011 to March 2014 our institution. The 28-joint count...
The optical rotatory dispersion and the circular dichroism curves of lycorine related compounds have been measured. considerations C2v symmetry transition aromatic chromophore in these allow a general rule to be deduced, like octant rule, which, for an α-band relates sign magnitude Cotton effect spatial orientation atoms about benzene chromophore. It is shown that effects number derivatives support rule.
To investigate clinical and radiological differences between joint destruction in the wrist feet patients with RA.A cross-sectional study was conducted an RA cohort at a single institution. Clinical data included age, sex duration of disease. Laboratory sero-positivity for anti-cyclic citrullinated peptide (CCP) antibody RF. Radiological measurements Larsen grades modified Sharp/van der Heijde method (SHS) hands/wrists feet. Statistical analyses were performed using Kruskal-Wallis H-test,...
Removal of orthopedic implants may sometimes be difficult because ongrowth new bone. Titanium screws can become encased or stripped during the process initial open reduction and internal fixation at time hardware removal. Difficulty in removing from a locking plate is particularly well-known. Two patients with tibial femoral diaphyseal fractures were treated using an intramedullary nail. However, after fracture healing, it was to remove screw reconstruction damage heads. The successfully...
Abstract A dipotassium diaquadiphosphatooctaperoxotetramolybdate, [K 2 (P O 7 ){MoO(O ) } {MoO(O (OH )} ] 2– , was crystallised as a tetramethylammonium salt and its structure determined by single‐crystal X‐ray diffraction. The diaquadiphosphatooctaperoxotetramolybdate moiety (POPMo4) consists of four molybdenum decahedra one μ 4 ‐diphosphate group. All Mo atoms bear two peroxo groups at their equatorial positions. Two the are also coordinated water molecule. separated linked diphosphate...
Modern three-component total ankle arthroplasty (TAA) has favorable clinical results and survival rates. However, radiographic deterioration worsening of symptoms may occur in patients with rheumatoid arthritis (RA) or non-inflammatory (NA). The associations between outcomes radiological factors are not clear. We compared midterm after TAA RA those NA.Twenty-six TAAs were performed using a prosthesis, the FINE Total Ankle System during study period. Fourteen 11 undergoing primary twelve 12...
Abstract Endocytic pathways are practical routes for the intracellular delivery of biomacromolecules. Along with this, effective strategies endosomal cargo release into cytosol desired to achieve successful delivery. Focusing on compositional differences between cell and membranes pH decrease within endosomes, we designed lipid‐sensitive pH‐responsive endosome‐lytic peptide HAad. This contains aminoadipic acid (Aad) residues, which serve as a safety catch preferential permeabilization over...
It is well known that acute myeloid leukemia (AML) characterized by lethargy, fever, pallor, and purpura. In children, however, skeletal symptoms may be present at onset in rare cases, such cases tend to misdiagnosed as osteomyelitis or septic arthritis. To distinguish from bone tumor, the utility of magnetic resonance imaging (MRI) has been discussed. We a pediatric case AML which initial manifestation was pain single bone, diagnosis aided marrow examination MRI. A one-year-old male with...
Using angle-resolved photoemission spectroscopy (ARPES) and density functional theory (DFT), an experimental theoretical study of changes in the electronic structure (dispersion dependencies) corresponding modification energy band gap at Dirac point (DP) for topological insulator (TI) $\mathrm{Mn}_{1-x} \mathrm{Ge}_x \mathrm{Bi}_2 \mathrm{Te}_4$ have been carried out with gradual replacement magnetic Mn atoms by non-magnetic Ge when concentration latter was varied from 10$\%$ to 75$\%$. It...
<title>Abstract</title> Using angle-resolved photoemission spectroscopy (ARPES) and density functional theory (DFT), an experimental andtheoretical study of changes in the electronic structure (dispersion dependencies) corresponding modification energyband gap at Dirac point (DP) for topological insulator (TI) Mn1−xGexBi2Te4 have been carried out with gradual replacementof magnetic Mn atoms by non-magnetic Ge when concentration latter was varied from 10% to 75%. It shownthat increases then...