Abstract Objective To compare retinal function assessed by full‐field electroretinography (ffERG) and multifocal (mfERG) in diabetes without retinopathy, with moderate non‐proliferative diabetic retinopathy (NPDR) the absence of diabetes. Methods Scotopic photopic ffERG mfERG was made non‐fasting volunteers, including 26 participants 22 NPDR using full International Society for Clinical Electrophysiology Vision protocols. Results Of responses, significant deviation (p ≤ 0.05, corrected...

The late post-illumination pupillary response (PIPR 10-30s ) to blue light is reduced in glaucoma, suggesting that pupillometry can be used clinical glaucoma evaluation. Since animal studies have indicated common anti-glaucomatous agents affect the iris muscle, we investigated short-term effect of anti-glaucoma drugs on reflex and particular PIPR10-30s.In this randomized, double-masked, crossover trial, was performed before after topical administration latanoprost, dorzolamide, timolol 20...

The intrinsically photosensitive retinal ganglion cells (ipRGCs) and sleep quality are impaired in patients with primary open-angle glaucoma (POAG). In this study, we investigated whether ipRGCs were also normal tension (NTG).We performed pupillometry assessment 15 NTG 17 healthy age-matched controls. Pupillometry protocol consisted of monocular stimulation high illuminance (100 lux) red (633 nm, 300 cd/m2 or 15.23 log quanta/cm2 /s) blue light (463 332 15.27 binocular pupil measurements....

We assessed the function of rod/cones and melanopsin in type 1 (T1DM) 2 diabetes mellitus (T2DM) with without non-proliferative diabetic retinopathy (NPDR).We performed pupillometry on 22 healthy controls four groups: 12 T1DM patients NPDR moderate NPDR, 16 T2DM NPDR. Monocular stimulations 20 seconds red (λ = 633 nm) blue light 463 at ~15 log quanta/cm2 /second were performed. The primary outcome was melanopsin-mediated late redilation phase postillumination pupillary response (PIPRLate )...

Visible light, predominantly in the blue range, affects mood and circadian rhythm partly by activation of melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs). The light-induced responses these can be evaluated pupillometry. study aimed to assess light induced pupil constriction patients with bipolar disorder (BD).We investigated pupillary chromatic pupillometry 31 newly diagnosed disorder, 22 their unaffected relatives 35 healthy controls. Mood state was...

To investigate the rod-cone and melanopsin pupillary light response (PLR) pathways in choroideremia.Eight patients with choroideremia 18 healthy age-matched controls underwent chromatic pupillometry by applying blue (463 nm) red (643 at 100 lux intensity to right eye while recording pupil diameters. Absolute baseline size (mm), normalized maximal constriction early late postillumination dilation, from 0 10 seconds 30 after end of illumination, respectively, were determined. Postillumination...

Continuous and intermittent stimuli with green light affect the pupillary response (PLR) differently. Since majority of pupillometric studies use blue red lights, we investigated effect continuous stimulations on PLR using lights.Seventeen healthy subjects underwent continuous- stimuli, (643 nm) (463 nm). To avoid influence pupil size amount entering eye, procedures were repeated stimulus-eye in dilated condition. The maximal constriction early redilation phase post-illumination (PIPREarly)...

Abstract Objective: Seasonal and non-seasonal depression are prevalent conditions in visual impairment (VI). We assessed the effects side of light therapy persons with severe VI/blindness who experienced recurrent depressive symptoms winter corresponding to seasonal affective disorder (SAD) or subsyndromal SAD (sSAD). Results: included 18 (11 VI, 3 perception 4 no perception) met screening criteria for sSAD/SAD a single-arm, assessor-blinded trial 6 weeks therapy. In 12 completed treatment,...

To report the effect of anti-vascular endothelial growth factor inhibitor (anti-VEGF) on fovea-involving cystoid macular edema in a patient with Birdshot chorioretinopathy.A 42-year-old male presented to our hospital bilateral posterior uveitis retinal vasculitis, and optic disc edem a. He was diagnosed birdshot chorioretinopathy based clinical appearance tissue type HLA-A29.The underwent vitrectomy right eye without any change visual acuity. Retinal leakage reduced by oral prednisolone,...

We report a novel finding on spectral domain optical coherence tomography in patients with choroideremia, which we describe as scleral pits (SCPs).Cross-sectional observational case series of 36 who underwent ophthalmic examination and multimodal imaging, including the macula. Optical images were reviewed for SCP, defined discrete tracts hyporeflectivity that traverse sclera or without involvement Bruch membrane, retinal pigment epithelium, retina. Unpaired two-tailed t-test Welch correction...

Aim In glaucoma, depression and disturbed sleep has been associated with degeneration of the intrinsically photosensitive retinal ganglion cells, that mediate non-image forming effects light such as regulation circadian rhythm, alertness mood. this study we assessed associations between seasonal mood behavior variation cell damage in outpatients glaucoma. Methods The pattern assessment questionnaire was administered to Data on visual field defects identified by autoperimetry nerve fiber...

Abstract Purpose To investigate the prevalence of optic disc drusen (ODD) and nerve head (ONH) morphology in patients diagnosed with normal tension glaucoma (NTG). Methods In this prospective cross‐sectional study, we included NTG from two units. both eyes, dense enhanced depth imaging optical coherence tomography volume scans ONH by means standardized scanning guidelines were performed to examine for presence ODD, radial used investigating parameters such as scleral canal diameter, cup/disc...

Primary open angle glaucoma is associated with an increased risk of mood and sleep disorders. These adversities have been suggested to relate a disrupted function the intrinsically photosensitive retinal ganglion cells (ipRGCs). The ipRGCs are key components in nonvisual photoreceptive system that mediates light effects on mood, circadian rhythm. We assessed diurnal hormone levels, pupillary responses under seasons different photoperiods 24 patients age- sex-matched healthy controls...

Introduction: we investigated the association between OSA and vision-threatening diabetic retinopathy (VTDR). Methods: used three nationwide registers to identify subjects with without patients type 1 (T1DM) or 2 diabetes mellitus (T2DM). The Danish Civil Registration System was link diagnosis. primary outcome occurrence of VTDR in OSA. secondary prevalence Results: included 532,828 comprising 13,279 (2.5%) 519,549 (97.5%). Diabetic had a 57% lower risk compared (OR 0.43, 95% CI 0.38–0.50, p...

Previously, it has been reported that melanopsin-mediated pupillary light response (PLR), measured with pupillometry, is reduced in patients idiopathic intracranial hypertension (IIH), indicating the clinical utility of tool diagnosis IIH. In current study, authors aimed to measure PLR 13 treatment-naive new-onset IIH and healthy controls. contrast previous report, which was based on longstanding (n = 13), found no significant difference (p 0.48).

To quantify the fluid resorption from centre of fovea in a pregnant woman with diabetic macular oedema by daily optical coherence tomography (OCT) measurements after administration intravitreal dexamethasone implant (Ozurdex® ).A 36-year-old type 1 diabetes for 33 years presented foveal serous detachment and symptomatic vision loss at 16 gestational weeks. Best-corrected visual acuity (BCVA) Snellen notation central retinal volume assessed (OCT, Topcon Corporation) were measured almost on...

Background & aims Sleep disturbances are related to hepatic encephalopathy and hyperammonaemia in patients with cirrhosis. The circadian rhythm is regulated by light stimulation of the retina via melanopsin-containing ganglion cells. study aimed investigate whether induced affects pupillary response sleep efficiency Methods was a single-blinded crossover trial including nine evaluated Pittsburgh Quality Index (PSQI) monitored for twelve nights wrist accelerometers diaries. On two...