A5050786536- Prenatal Substance Exposure Effects
- Maternal Mental Health During Pregnancy and Postpartum
- Opioid Use Disorder Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Veterinary Equine Medical Research
- Korean Urban and Social Studies
- Hedgehog Signaling Pathway Studies
- Diverse Topics in Contemporary Research
- Psychosocial Factors Impacting Youth
- Cytomegalovirus and herpesvirus research
- War, Ethics, and Justification
- Platelet Disorders and Treatments
- RNA regulation and disease
- Veterinary Oncology Research
- Hepatitis Viruses Studies and Epidemiology
- Congenital heart defects research
- Cell Adhesion Molecules Research
- Proteoglycans and glycosaminoglycans research
- Cardiac Valve Diseases and Treatments
- Infectious Diseases and Mycology
- interferon and immune responses
- Genetic and Kidney Cyst Diseases
- Gestational Diabetes Research and Management
- Epigenetics and DNA Methylation
- Connective tissue disorders research
St. Jude Children's Research Hospital
2024
Imaging Center
2024
Medical College of Wisconsin
2018-2019
Veterinary Medical Teaching Hospital
2019
University of California, Davis
2019
Medical University of South Carolina
2015
Human cytomegalovirus (HCMV) replicates in several cell types throughout the body, causing disease absence of an effective immune response. Studies on HCMV require cultured human cells and tissues due to species specificity. In these studies, we investigated impact infection developing three-dimensional cortical organoid tissues, with specific emphasis cell-type-dependent calcium signaling. Calcium signaling is essential function during neural differentiation development. We observed that...
Sonic Hedgehog (SHH) is a driver of embryonic patterning that, when corrupted, triggers developmental disorders and cancers. SHH effector responses are organized through primary cilia (PC) that grow retract with the cell cycle in response to extracellular cues. Disruption PC homeostasis corrupts regulation, placing significant pressure on pathway maintain ciliary fitness. Mechanisms by which robustness ensured SHH-stimulated cells not yet known. Herein, we reveal crosstalk circuit induced...
Mutations in the actin-binding gene Filamin-A have been linked to non-syndromic myxomatous valvular dystrophy and associated mitral valve prolapse. Previous studies by our group traced adult defects back developmental errors interstitial cell-mediated extracellular matrix remodeling during fetal gestation. Mice deficient exhibit enlarged leaflets at E17.5, subsequent progression a phenotype is observed two months. For this study, we sought define mechanisms that contribute degeneration...