A5101707331- Supercapacitor Materials and Fabrication
- Advanced battery technologies research
- Advancements in Battery Materials
- Immune Response and Inflammation
- Cellular Mechanics and Interactions
- Quantum Dots Synthesis And Properties
- Cellular transport and secretion
- Microfluidic and Bio-sensing Technologies
- Tendon Structure and Treatment
- Bone Metabolism and Diseases
- Protein Kinase Regulation and GTPase Signaling
- Autophagy in Disease and Therapy
- Galectins and Cancer Biology
- Silk-based biomaterials and applications
- Phagocytosis and Immune Regulation
- Bone health and treatments
- Chalcogenide Semiconductor Thin Films
- Pluripotent Stem Cells Research
- Perovskite Materials and Applications
- RNA Interference and Gene Delivery
- Tissue Engineering and Regenerative Medicine
- Virus-based gene therapy research
- NF-κB Signaling Pathways
- 3D Printing in Biomedical Research
- Radiation Detection and Scintillator Technologies
Korea University
2018-2024
Kookmin University
2017-2024
Seoul National University
2020-2023
Korea Advanced Institute of Science and Technology
2022-2023
Mechanistic target of rapamycin (mTOR) is a key protein kinase that integrates various internal and external signals to control biological events including cell growth. Whereas substantial efforts were made elucidate subunits interacting with mTOR, endogenous metabolite-mTOR interactions remain largely unknown. Using affinity purification mass spectrometry, we identified direct binding mTOR 13-S-hydroxyoctadecadienoic acid (13-S-HODE) which an oxygenated metabolite linoleic acid,...
The onset of osteoporosis leads to a gradual decrease in bone density due an imbalance between formation and resorption. To achieve optimal drug efficacy with minimal side effects, targeted delivery the is necessary. Previous studies have utilized peptides that bind hydroxyapatite, mineral component bone, for bone-targeted delivery. In this study, hydroxyapatite binding (HAB) tag fused 30Kc19α-Runt-related transcription factor 2 (RUNX2) bone-targeting. This recombinant protein can penetrate...
The major problem of transition metal oxide (TMO)-based supercapacitors is their low specific energy (E sp) due to the poor electrical conductivity TMO electrodes and narrow operating voltage window. To solve these limitations simultaneously, we propose asymmetric (ASCs) consisting two composite working in different potential ranges. Titanium dioxide (TiO2) nanoparticle (NP)-incorporated iron (Fe2O3) manganese (MnO2) NPs were used as electrode materials covering negative positive window,...
Inositol polyphosphate multikinase (IPMK) is a pleiotropic enzyme responsible for the production of inositol polyphosphates and phosphoinositide. IPMK in macrophages was identified as key factor full activation Toll-like receptor 4 (TLR4) signaling pathway inflammation by directly interacting with tumor necrosis receptor-associated 6 (TRAF6). Here, dynamic changes levels lipopolysaccharide (LPS)-stimulated their functional significance were investigated. Both mRNA protein acutely decreased...
The interplay between soil micro-organisms in mountain ecosystems critically influences biogeochemical cycles and ecosystem processes. However, factors affecting the co-occurrence patterns of microbial communities remain unclear. In an attempt to understand how these shift with elevation identify key explanatory underpinning changes, we studied bacterial fungal networks on Mt. Seorak, Republic Korea. Amplicon sequencing was used target 16S rRNA gene ITS2 region for bacteria fungi,...
Human mesenchymal stem cells (hMSCs) are a commonly used cell source for therapy and tissue engineering because of their easy accessibility multipotency. Runt-related transcription factor 2 (RUNX2) is master regulator the osteogenic commitment hMSCs. Either recombinant plasmid delivery or viral transduction has been utilized to activate RUNX2 gene expression effective hMSC differentiation. In this study, fused with cell-penetrating 30Kc19α protein (30Kc19α-RUNX2) was delivered into hMSCs...
We report a high-speed lateral flow strategy for fast biosensing with an improved selectivity and binding affinity even under harsh conditions. In this strategy, biosensors were fixed at location away from the center of round shape disk, disk was rotated to create target solution on during sensing measurements. Experimental results using showed high reaction speeds, affinity, low nonspecific adsorptions molecules biosensors. Furthermore, between enhanced in conditions such as pH ionic...
Abstract The instability of recombinant basic fibroblast growth factor (bFGF) is a major disadvantage for its therapeutic use and means frequent applications to cells or tissues are required sustained effects. Originating from silkworm hemolymph, 30Kc19α cell‐penetrating protein that also has stabilization properties. Herein, it investigated whether fusing bFGF can enhance the stability skin penetration properties bFGF, which may consequently increase efficacy. fusion increases stability, as...
A family of inositol hexakisphosphate kinases (IP6Ks) catalyzes the production pyrophosphate IP7 (5-diphosphoinositolpentakisphosphate) which is known to modulate various biological events such as cell growth. While targeting IP6K1 in cancer cells has been well reported control motility and invasiveness, role host tumor progression remains unknown. By using a syngeneic MC38 murine mouse colon carcinoma model, here we examined how microenvironment influences In knockout (KO) mice, growth was...
Acute stress response triggers various physiological responses such as energy mobilization to meet metabolic demands. However, the underlying molecular changes in brain remain largely obscure. Here, we used a brief water avoidance (WAS) elicit an acute mice. By employing RNA-sequencing and metabolomics profiling, investigated stress-induced mouse whole brain. The aberrant expression of 60 genes was detected tissues WAS-exposed Functional analyses showed that aberrantly expressed were...
Induced pluripotent stem cells (iPSCs) have intrinsic properties, such as self-renewal ability and pluripotency, which are also shown in embryonic (ESCs). The challenge of improving the iPSC generation efficiency has been an important issue there many attempts to develop methods. In this research, we added Lin28, known one reprogramming factors, form a soluble recombinant protein from E. coli improve human (hiPSC) generation, respect alkaline phosphatase (AP)-positive colonies. To deliver...