A5008609062- Advancements in Transdermal Drug Delivery
- Wound Healing and Treatments
- Dermatology and Skin Diseases
- Silk-based biomaterials and applications
- Photochromic and Fluorescence Chemistry
- Advanced Drug Delivery Systems
- melanin and skin pigmentation
- Skin Protection and Aging
- Lipid Membrane Structure and Behavior
- Electrospun Nanofibers in Biomedical Applications
- Biochemical and Structural Characterization
- Olfactory and Sensory Function Studies
- RNA Interference and Gene Delivery
- Periodontal Regeneration and Treatments
- Supramolecular Self-Assembly in Materials
- Antimicrobial Peptides and Activities
- Polydiacetylene-based materials and applications
- Tissue Engineering and Regenerative Medicine
- Innovative Microfluidic and Catalytic Techniques Innovation
- Allergic Rhinitis and Sensitization
- Tendon Structure and Treatment
- Electrochemical sensors and biosensors
- Biochemical Analysis and Sensing Techniques
- Planarian Biology and Electrostimulation
- Advanced Sensor and Energy Harvesting Materials
Seoul National University
2020-2025
We herein developed an iontophoretic transdermal drug delivery system for the effective of electrically mobile nanocarriers (DNs). Our consists a portable and disposable reverse electrodialysis (RED) battery that generates electric power iontophoresis through ionic exchange. In addition, in order to provide reservoir RED-driven system, electroconductive hydrogel composed polypyrrole-incorporated poly(vinyl alcohol) (PYP) was used. The PYP facilitated electron transfer from RED accelerated...
Recently, the stem cell-derived secretome, which is set of proteins expressed by cells and secreted into extracellular space, has been demonstrated as a critical contributor for tissue repair. In this study, we have produced two sets high concentration secretomes from adipose-derived mesenchymal (ADSCs) that contain bovine serum or free exogenous molecules. Through proteomic analysis, elucidated related to matrix organization growth factor-related are highly ADSCs. Additionally, application...
Tyrosinase-mediated melanin synthesis is an essential biological process that can protect skin from UV radiation and radical species. This work reports on in situ biosynthesis of artificial native using photoactivatable tyrosinase (PaTy). The I41Y mutant Streptomyces avermitilis (SaTy) shows enzymatic activity comparable to wild-type SaTy. Y41 replaced with photocleavable o-nitrobenzyl tyrosine (ONBY) the introduction amber codon ONBY-tRNA synthetase/tRNA pairs. ONBY efficiently blocks...
Abstract Chronic wounds adversely affect the quality of life. Although electrical stimulation has been utilized to treat chronic wounds, there are still limitations practicing it due complicated power system. Herein, an electrostimulating membrane incorporated with electrospun nanofiber (M‐sheet) diabetic is developed. Through screen printing method, various alternate patterns both Zn and AgCl on a polyurethane substrate, generating redox‐mediated fields introduced. The antibacterial ability...
Transdermal or topical skin delivery of protein therapeutics is currently limited due to the large molecular size proteins and dense structure skin. Although some nanoparticles enhancers have been used increase penetration stability, few studies examined effect combination on penetration. Here, we introduce Polycaprolactone (PCL) Pluronic F-127-based polymeric (PNPs) load different-sized proteins, including insulin (INS), trypsin inhibitor (TI), horseradish peroxidase (HRP), bovine serum...
Abstract Since the development of protein‐based therapeutics, research has been underway to deliver protein therapeutics into systemic circulation and target sites have actively conducted. Most require parenteral administration, due their intrinsic vulnerability susceptibility enzyme‐mediated degradation. Among routes transdermal delivery system regarded as a promising technique offering advantages painless ease termination, avoidance first‐pass metabolism. However, unlike small molecular...
Polyphenols have been investigated for their potential to mitigate inflammation in the context of atopic dermatitis (AD). In this study, epigallocatechin-3-gallate (EGCG)-based carbon dots (EGCG@CDs) were developed enhance transdermal penetration, reduce inflammation, recapitulate superoxide dismutase (SOD) activity, and provide antimicrobial effects AD treatment. The water-soluble EGCG@CDs a few nanometers size exhibit negative zeta potential, making them suitable effective penetration....
Protein therapeutics are emerging as essential technologies due to their functional and chemical properties. However, application is currently limited delivery by oral injection methods—the former being inefficient the latter invasive potentially tissue damaging. Researchers are, therefore, exploring noninvasive systems for proteins through skin, including transdermal topical delivery. The large molecular size of presents a key challenge skin penetration, hindering ability penetrate dense...
Although the polyphenols have been studied to alleviate inflammation, there are still challenges delivering with stabilized formulation due their low water solubility and susceptibility oxidation. Herein, transdermal delivery system of polyphenol mixture (PM), including quercetin (Q), phloretin (P), ellagic acid (E), is developed using double emulsion for applying atopic dermatitis (AD). Through in vitro anti-degranulation assay, optimal molar ratio each (Q:P:E = 5:1:1) obtained, PM shows at...
When the skin is exposed to ultraviolet radiation (UV), it leads degradation of extracellular matrix (ECM) and results in inflammation. Subsequently, melanocytes are triggered induce tyrosinase-mediated melanin synthesis, protecting skin. Here, we introduce a proactive approach protect from photodamage via topical delivery Streptomyces avermitilis-derived tyrosinase (SaTy) using single-walled carbon nanotube (SWNT). Utilizing reverse electrodialysis (RED) battery, facilitated SaTy-SWNT...
Abstract The instability of recombinant basic fibroblast growth factor (bFGF) is a major disadvantage for its therapeutic use and means frequent applications to cells or tissues are required sustained effects. Originating from silkworm hemolymph, 30Kc19α cell‐penetrating protein that also has stabilization properties. Herein, it investigated whether fusing bFGF can enhance the stability skin penetration properties bFGF, which may consequently increase efficacy. fusion increases stability, as...
Abstract The growing societal concern regarding skin aging caused by ultraviolet (UV) exposure has spurred the quest for effective therapeutic solutions. Among these, secreted factors derived from adipose‐derived stem cells (ADSC) have emerged as promising candidates with anti‐photoaging properties. secretome of ADSC stimulates resident fibroblasts, triggering antioxidant effects and promoting synthesis extracellular matrix, thus counteracting photoaging. In this study, potential dried...
Artificial Melanosome for Transdermal Delivery In article number 2103503 by Uk-Jae Lee, Nathaniel S. Hwang, Byung-Gee Kim, and co-workers, light-triggered in situ biosynthesis of artificial melanin native skin is proposed demonstrated using photoactivatable tyrosinase. Photoactivatable tyrosinase synthesized with site-specific incorporation o-nitrobenzyl tyrosine then encapsulated into lipid nanoparticles as an melanosome transdermal delivery. This biomimetic system can recapitulate the...
The instability of recombinant basic fibroblast growth factor (bFGF) is a major disadvantage for its therapeutic use. In article number 2000176, Nathaniel S. Hwang, Tai Hyun Park, and co-workers fuse bFGF with 30Kc19α protein to enhance the stability tissue penetration bFGF. When applied wound site, 30Kc19α-bFGF fusion (blue-purple) facilitates regeneration by acting on fibroblasts endothelial cells in dermal layer