A5012508243- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Eosinophilic Esophagitis
- Air Quality and Health Impacts
- Malaria Research and Control
- Immunodeficiency and Autoimmune Disorders
- Urticaria and Related Conditions
- Computational Drug Discovery Methods
- Complement system in diseases
- Drug-Induced Adverse Reactions
- Pediatric health and respiratory diseases
- RNA regulation and disease
- Lipid Membrane Structure and Behavior
- Food Security and Health in Diverse Populations
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Contact Dermatitis and Allergies
- Respiratory viral infections research
- Indoor Air Quality and Microbial Exposure
- Hair Growth and Disorders
- Birth, Development, and Health
- Receptor Mechanisms and Signaling
- Myasthenia Gravis and Thymoma
- Mast cells and histamine
- Child and Adolescent Health
Icahn School of Medicine at Mount Sinai
2019-2024
ENT and Allergy
2023
New York Proton Center
2018-2021
Mount Sinai Hospital
2019
Texas Children's Hospital
2018
Baylor College of Medicine
2016-2018
Tri-Institutional PhD Program in Chemical Biology
2012-2015
Cornell University
2012-2015
Columbia University Irving Medical Center
2009
A wide variety of phytochemicals are consumed for their perceived health benefits. Many these have been found to alter numerous cell functions, but the mechanisms underlying biological activity tend be poorly understood. Phenolic particularly promiscuous modifiers membrane protein function, suggesting that some actions may due a common, bilayer-mediated mechanism. To test whether bilayer perturbation underlie this diversity actions, we examined five bioactive phenols reported medicinal...
Deletion of the acyltransferases responsible for triglyceride and steryl ester synthesis in Saccharomyces cerevisiae serves as a genetic model diseases where lipid overload is component. The yeast mutants lack detectable neutral lipids cytoplasmic droplets are strikingly sensitive to unsaturated fatty acids. Expression human diacylglycerol acyltransferase 2 was sufficient reverse these phenotypes. Similar mammalian cells, acid-mediated death apoptotic presaged by transcriptional induction...
Clinical Implications•We describe 3 patients with X-linked agammaglobulinemia coronavirus disease 2019 who failed supportive treatment but recovered after receiving convalescent plasma. •We The (COVID-19) pandemic has presented a global challenge. pathogenesis of severe acute respiratory syndrome 2 (SARS-CoV-2) infection is complex, and effective therapy currently lacking. Convalescent plasma transfusion safe under investigation for effectiveness.1Bloch E.M. Shoham S. Casadevall A. Sachais...
Anaphylaxis is a rapid-onset, multisystem, and potentially fatal hypersensitivity reaction with varied reports of prevalence, incidence, mortality. There are limited cases reported severe and/or pediatric anaphylaxis.
The most severe form of human malaria is caused by the parasite Plasmodium falciparum. second messenger cAMP has been shown to be important for parasite's ability infect host's liver, but its role during growth inside erythrocytes, stage responsible symptomatic malaria, less clear. P. falciparum genome encodes two adenylyl cyclases, enzymes that synthesize cAMP, PfACα and PfACβ. We now show one these, PfACβ, plays an erythrocytic life cycle. Biochemical characterization PfACβ revealed a...
Advertising Disclaimer » Main menu JournalsPediatrics Hospital Pediatrics in Review NeoReviews AAP Grand Rounds News Authors/ReviewersSubmit Manuscript Author Guidelines Reviewer Open Access Editorial Policies ContentCurrent Issue Online First Archive Blogs Topic/Program Collections Meeting Abstracts Pediatric CollectionsCOVID-19 Racism and Its Effects on Health More Collections... Policy SupplementsSupplements Publish Supplement MultimediaVideo On Call Podcast Subscribe Alerts Careers Other...
Because of the perpetual development resistance to current therapies for malaria, Medicines Malaria Venture developed Box facilitate drug process. We tested 80 most potent compounds from box bilayer-mediated effects on membrane protein conformational changes (a measure likely toxicity) in a gramicidin-based stopped flow fluorescence assay. Among tested, four altered properties (p< 0.05); MMV007384 stood out as bilayer-perturbing compound that is toxic many cell-based assays, suggesting...
Background Investigations of maternal psychosocial stress and child asthma have produced mixed findings, which may reflect inconsistent consideration modifying factors.
To identify the measurable physiologic changes in small airways of children with asthma, when employing a 2.5 µm particulate matter (PM2.5) filtration device their bedrooms.The population enrolled includes mild or moderate asthma who live suburb Shanghai, China, during low-ozone season. A total 43 (5–13 years old; 60% boys) are included analysis.Patients randomly assigned into either arm double-blind crossover study design 3 consecutive 14 day periods true filtration-washout-sham reverse...
To compare findings on endoscopy and histology after children with eosinophilic esophagitis (EoE) were treated swallowed fluticasone propionate (FP) or oral viscous budesonide (OVB).Sixty-eight subjects who diagnosed EoE between 1 20 years old included in the study. Subjects had therapy FP OVB for at least 8 weeks pre- posttherapy evaluation by using endoscopy. There patients 48 The mostly male (81%) Caucasian (68%). Patients inflammatory bowel disease, celiac and/or gastritis excluded from...
Background: Chronic food protein‐induced enterocolitis syndrome (FPIES) is a cell-mediated gastrointestinal hypersensitivity described almost exclusively in infants fed cow’s milk or soy formula. A timely diagnosis challenging due to number of factors, including broad differential diagnoses, absence specific biomarkers, and delayed symptom onset. Objective: This report aimed highlight how the severity presentation can further impede chronic FPIES. Methods: case presumed FPIES with previously...
To assess the relationship between type of participation in US Department Housing and Urban Development (HUD) rental assistance programs with childhood asthma outcomes, such as emergency department (ED) or urgent care center (UC) use, diagnosis, exacerbations.The population studied includes 2992 children, representative population, 0 17 years old who were receiving had not yet applied (WLG) to receive January 1, 1999, December 31, 2014. These records linked National Health Interview Survey....