A5009367184- Pharmacological Effects of Natural Compounds
- Paraoxonase enzyme and polymorphisms
- Genetics, Aging, and Longevity in Model Organisms
- Ginseng Biological Effects and Applications
- Medicinal Plants and Bioactive Compounds
- Circadian rhythm and melatonin
- Birth, Development, and Health
- Skin Protection and Aging
- Endoplasmic Reticulum Stress and Disease
- Liver Disease Diagnosis and Treatment
- Retinal Diseases and Treatments
- Coenzyme Q10 studies and effects
- Animal Genetics and Reproduction
- Online and Blended Learning
- Online Learning and Analytics
- Biochemical Acid Research Studies
- Species Distribution and Climate Change
- Virus-based gene therapy research
- Retinal Development and Disorders
- Cynara cardunculus studies
- Viral Infectious Diseases and Gene Expression in Insects
- Telomeres, Telomerase, and Senescence
- Apelin-related biomedical research
- Parkinson's Disease Mechanisms and Treatments
Glaceum (South Korea)
2020-2024
The University of Sydney
2022
Suwon Research Institute
2022
Princeton University
2020-2021
Glabridin is a polyphenolic compound with reported anti-inflammatory and anti-oxidative effects. In the previous study, we synthesized glabridin derivatives-HSG4112, (S)-HSG4112, HGR4113-based on structure-activity relationship study of to improve its biological efficacy chemical stability. present investigated effects derivatives in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. We found that synthetic significantly dose-dependently suppressed production nitric oxide (NO)...
Abstract Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent immuno-metabolic that can progress to hepatic cirrhosis and cancer. NAFLD pathogenesis extremely complex characterized by oxidative stress, impaired mitochondrial function lipid metabolism, cellular inflammation. Thus, in-depth research on its underlying mechanisms subsequent investigation into a potential drug target has overarching effects these features will help in the discovery of effective treatments for...
Reproduction comes at a cost, including accelerated death. Previous studies of the interconnections between reproduction, lifespan, and fat metabolism in C. elegans were predominantly performed low-reproduction conditions. To understand how increased reproduction affects lifespan metabolism, we examined mated worms; find that Δ9 desaturase, FAT-7, is significantly up-regulated. Dietary supplementation oleic acid (OA), immediate downstream product FAT-7 activity, restores storage completely...
The process of cellular senescence, which is characterized by stable cell cycle arrest, strongly associated with dysfunctional metabolism and circadian rhythmicity, both are reported to result from also be causal senescence. As a result, modifying any them—senescence, metabolism, or the clock—may affect all three simultaneously. Obesity accelerates aging disrupting homeostasis reactive oxygen species (ROS) via an increased mitochondrial burden fatty acid oxidation. if rhythm linked,...
Abstract Background HSG4112 is a clinical-stage drug candidate for the treatment of obesity. Here, we report its discovery and preclinical efficacy. Methods In high-fat diet (HFD)-induced obese male C57BL/6J mice, tested weight loss effect synthetic compounds derived from structure–activity relationship (SAR) study glabridin, natural compound known to reduce body influence energy homeostasis. After selecting as our optimized this method, characterized pharmacological effects on parameters...
Only limited therapeutic agents have been developed for non-alcoholic steatohepatitis (NASH). Glabridin, a promising anti-obesity candidate, has only druggability due to its low in vivo chemical stability and bioavailability. Therefore, we vutiglabridin (VUTI), which is based on glabridin backbone, investigated mechanism of action treating NASH animal models.
Advances in digital technologies have given rise to 'citizen science' which engages non-professionals scientific research and provides participants with diverse learning opportunities. However, evaluating such outcomes has proven challenging many biases unexplored dimensions. This study aimed assess processes through participation E$$ENTIAL MEDICINE$ - a citizen science initiative investigates the world's most important medicines using data available online. To attain an account of...
Abstract The process of cellular senescence, which is characterized by stable cell cycle arrest, strongly associated with dysfunctional metabolism and circadian rhythmicity, both are reported to result from also be causal senescence. As a result, modifying any them - metabolism, or the clock may affect all three simultaneously. Obesity accelerates aging disrupting homeostasis reactive oxygen species (ROS) via an increased mitochondrial burden fatty acid oxidation. if rhythm linked,...
Background: HSG4112 is a clinical-stage drug candidate for the treatment of obesity. Here, we report its discovery and preclinical efficacy. Methods: In high-fat diet (HFD)-induced obese male C57BL/6J mice, tested weight loss effect synthetic compounds derived from structure-activity relationship (SAR) study glabridin, natural compound known to reduce body influence energy homeostasis. After selecting as our optimized this method, characterized pharmacological effects on parameters related...
Vutiglabridin is a clinical-stage synthetic small molecule that being developed for the treatment of obesity and its target proteins have not been fully identified. Paraoxonase-1 (PON1) an HDL-associated plasma enzyme hydrolyzes diverse substrates including oxidized low-density lipoprotein (LDL). Furthermore, PON1 harbors anti-inflammatory antioxidant capacities has implicated as potential therapeutic treating various metabolic diseases. In this study, we performed non-biased deconvolution...
Abstract Parkinson’s disease (PD), characterized by degeneration of dopaminergic neurons, share pathogenic features with obesity, including mitochondrial dysfunction and oxidative stress. Paraoxonase 2 (PON2) is an inner membrane protein that highly expressed in neurons involved the regulation However, no drug targeting PON2 has ever been developed for treatment PD. Here, we show vutiglabridin, a clinical phase 2-stage therapeutic effects PD models, PON2. Vutiglabridin penetrates into brain,...
Abstract Reproduction comes at a cost, including death. Previous studies of the interconnections between reproduction, lifespan, and fat metabolism in C. elegans were predominantly performed low-reproduction conditions. To understand how increased reproduction affects lifespan metabolism, we examined mated worms; find that Δ9 desaturase, FAT-7, is significantly up-regulated. Dietary supplementation oleic acid (OA), immediate downstream product FAT-7 activity, restores storage completely...
Abstract Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent immuno-metabolic that can progress to hepatic cirrhosis and cancer. NAFLD pathogenesis extremely complex characterized by oxidative stress, impaired mitochondrial function lipid metabolism, cellular inflammation. Thus, in-depth research on its underlying mechanisms subsequent investigation into a potential drug target has overarching effects these features will help in the discovery of effective treatments for...